Alteraciones de la inmunidad tras adenoidectomía y amigdalectomía

Sebastiá, L.I. Amorós; Ramı́rez, Marı́a José; Mollá, C. López; Carrasco-Llatas, Marina; Mochilí, A. Plá; Ferriol, José Enrique Estellés; López‐Martínez, Rafael; Ruiz, Mgh

doi:10.1016/s0001-6519(04)78544-1

Cited by 9 publications

(3 citation statements)

References 10 publications

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“…The origin of these alterations is still uncertain, but they may be related to surgical stress, reduction of immunoglobulin-producing lymphoid tissue, and reduction of antigen load 3 , 6 , 9 , 12 , 18 , 21 . Additionally, these alterations have not adversely impacted the frequency of occurrence or the severity of upper airway infection, differently from what was previously believed 12 , 18 , 25 .…”

Section: Discussionmentioning

confidence: 99%

Short and long term impact of adenotonsillectomy on the immune system

Santos

Weber²,

Fortes

et al. 2013

Brazilian Journal of Otorhinolaryngology

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Section: Discussionmentioning

confidence: 99%

Short and long term impact of adenotonsillectomy on the immune system

Santos

Weber²,

Fortes

et al. 2013

Brazilian Journal of Otorhinolaryngology

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“…Kaygusuz et al [8] indicated that 1 month after tonsillectomy, the level of CD4+ was significantly increased while the level of CD25+ was reduced, and immunoglobulins as well as C3 and C4 were decreased after tonsillectomy. Amorós Sebastiá et al [4] studied 5 to 9 years old children and found that serum IgG levels dropped after adenoidectomy, but partially only recovered 4 months later. IgA dropped less significantly and IgM did not change.…”

Section: Discussionmentioning

confidence: 99%

“…Adenoids and tonsils are important organs of human immune system that protect the body from pathogens invading the upper respiratory tract, [1] especially in young children. As the largest components of Waldeyer ring, [2–4] they are secondary lymphoid organs, and part of the mucosa-associated lymphoid tissue. [5,6]…”

Section: Introductionmentioning

confidence: 99%

Short- and long-term impacts of adenoidectomy with/without tonsillectomy on immune function of young children <3 years of age

Yan¹,

Song²,

Liu³

et al. 2019

Medicine

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To investigate the short- and long-term impacts of adenoidectomy with/without tonsillectomy on the immune functions of young children < 3 years of age. This longitudinal prospective study included 40 pediatric patients (age <3 y) undergoing adenoidectomy with/without tonsillectomy for snoring and sleep apnea. Serum immunoglobulin IgA, IgG, IgM, complement C3, and C4 levels were measured for the status of humoral immunity; CD3+, CD4+, CD8+, CD4+/CD8+, CD19+, CD56+, CD3+CD4-CD8-, and CD3+CD4+CD8+ T cells were measured for the status of cellular immunity. Blood samples were taken at 3 time points: before surgery, 1 month after surgery (short-term), and 3 months after surgery (long-term). All patients were assessed for short-term outcome at 1-month postoperation, but only 30 patients were followed at 3 months after surgery. The incidence of recurrent respiratory tract infections and other immune-related conditions were recorded at each follow-up. The levels of IgA significantly decreased from the preoperative level at 1-month follow-up ( P < .05), but still within normal range. No significant changes were found in the levels of IgA, IgG, IgM, C3, C4, CD3+, CD4+, CD8+, CD4+/CD8+, CD19+, CD56+, CD3+CD4-CD8-, and CD3+CD4+CD8+ T cell at 3-month follow-up in comparison with preoperative levels. There was also no episode of recurrent respiratory tract infection and other immune-deficiency conditions. Adenoidectomy with/without tonsillectomy may result in a reduction in individual antibodies in children <3 years of age, but did not show negative impacts on their immune functions. Also, the surgery does not lead to the increased risk of upper respiratory tract infection in these children.

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Ribosomal therapy in the treatment of recurrent acute adenoiditis

Mora

Dellepiane

Crippa

et al. 2010

Eur Arch Otorhinolaryngol

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The aim of this study was to evaluate the efficacy of an oral ribosomal immunotherapy in the management of children with recurrent acute adenoiditis (RAA). 60 children with RAA were included and randomly assigned into two groups (group A and B). Group A children underwent ribosomal prophylaxis, while group B received a placebo. Before, at the end and 6 months after start of the therapy, children underwent medical history, ENT examination, plasma levels of immunoglobulins class E, A, G, M (IgE, IgA, IgG, IgM), tympanometry, active anterior rhinomanometry and VAS scores by children' parents. After the treatment and at the end of the study, in the group A, the serum concentration of IgE was significantly (P < 0.05) lower than in group B (77.34 +/- 6.23 vs. 95.49 +/- 7.07 mg/dl; 74.82 +/- 6.26 vs. 94.44 +/- 7.44 mg/dl), IgA titers were significantly (P < 0.05) higher than in group B (312.04 +/- 18.41 vs. 213.20 +/- 11.82; 309.07 +/- 18.33 vs. 211.73 +/- 11.54 mg/dl) as well as serum concentration of IgG (1401.12 +/- 118.81 vs. 1101.81 +/- 109.64 mg/dl; 1412.19 +/- 116.43 vs. 1144.06 +/- 103.58 mg/dl). At the end of the study, comparison between the two groups showed, in group A: 77% of children (n = 23), versus 23% (n = 7) of group B, with a type A tympanogram; significant (P < 0.05) nasal flow decrease at the rhinomanometric measures; VAS scores were significantly (P < 0.05) improved (1.8 +/- 0.22 vs. 5.1 +/- 0.59) and frequency, severity and social impact of RAA episodes were significantly (P < 0.05) lower than group B. Our results show the therapeutic effectiveness of this approach in the prophylaxis of recurrent acute adenoiditis.

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Alteraciones de la inmunidad tras adenoidectomía y amigdalectomía

Cited by 9 publications

References 10 publications

Short and long term impact of adenotonsillectomy on the immune system

Short and long term impact of adenotonsillectomy on the immune system

Short- and long-term impacts of adenoidectomy with/without tonsillectomy on immune function of young children <3 years of age

Ribosomal therapy in the treatment of recurrent acute adenoiditis

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