Alterações cardiovasculares na anemia falciforme

Martins, Wolney de Andrade; Mesquita, Evandro Tinoco; Cunha, Duanny Murinelly de Souza; Ferrari, Anelise Hagen; Pinheiro, Luiz Augusto de Freitas; Fo, Luiz José Martins Romêo; Pareto, Raul C.

doi:10.1590/s0066-782x1998000500012

Cited by 16 publications

(19 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These complications include severe musculoskeletal and cardiovascular pain, which clinically manifests as palpitations, dyspnea, and fatigue; these symptoms worsen during physical exercise. The primary factors responsible for cardiovascular manifestations are vaso-occlusive events, which prevent the transport of oxygen to the tissues (Ingram, 1989;Martins et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

“…A preventative physiotherapeutic approach for the treatment of complications resulting from sickle cell anemia is rarely reported in the literature (Ingram, 1989;Martins et al, 1998), but the literature does encourage the use of physiotherapy as part of an interdisciplinary treatment program that offers the adequate attention needed by these patients (Naoum and Naoum, 2004). We examined the effects of kinesiotherapy and aquatic rehabilitation on pain levels and lung capacity in an adult woman with sickle cell anemia.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Case Report Benefits of kinesiotherapy and aquatic rehabilitation on sickle cell anemia. A case report

Tinti

Somera²,

Valente³

et al. 2010

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. The process of hemoglobin polymerization and the consequent sickling of red blood cells that occurs in patients with sickle cell disease shortens the half-life of red blood cells. It causes vaso-occlusive complications, as well as pain and pulmonary and cardiovascular dysfunction. We evaluated an aquatic rehabilitation program used for patients with sickle cell anemia and examined the possible benefits that exercise in warm water has for the circulatory system, for relieving pain, and for increasing lung capacity. The patient was a 32-year-old female. The parameters that we used in this study include respiratory muscle strength (which was calculated by measuring maximum inspiratory pressures and maximum expiratory pressures), the McGill and Wisconsin pain questionnaires (in order to evaluate the patients' characterizations and descriptions of their pain), and the SF-36 Health Survey. The treatment included warm water exercises, stretching, aerobic exercise, and relaxation, during two sessions of 45 min per week for 5 weeks. The patient experienced a significant decrease in pain, a significant increase in 361 ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 9 (1): 360-364 (2010) Aquatic rehabilitation in sickle cell anemia the strength of respiratory muscles, and improved quality of life. We conclude that aquatic rehabilitation can be used to improve the clinical condition of sickle cell anemia patients, and we encourage more research on this new treatment regime, in comparison with other types of therapies.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Case Report Benefits of kinesiotherapy and aquatic rehabilitation on sickle cell anemia. A case report

Tinti

Somera²,

Valente³

et al. 2010

Genet. Mol. Res.

View full text Add to dashboard Cite

show abstract

“…(27) From this finding we may also infer that the aerobic functional capacity measured by VO 2 max is diminished in sickle cell disease patients, not only because of cardiovascular or pulmonary involvement, (6) but also because of presenting an altered basal metabolism, that is to say, permanently in metabolic acidosis.…”

Section: Discussionmentioning

confidence: 90%

“…(37) It is well known that extreme levels of acidemia cause various undesirable effects on cell function. Among these effects one may point out weakness and fatigue of the respiratory musculature, (38) an increase in insulin resistance and consequent increase in protein catabolism, (36) which may explain the sarcopenia observed in sickle cell disease individuals, reduction in cardiovascular response at effort and reductions in myocardial contractility, (6) as well as increases in pulmonary vascular resistance. This explains the high number of sickle cell disease patients that develop pulmonary hypertension.…”

Section: Discussionmentioning

confidence: 99%

Resting blood lactate in individuals with sickle cell disease

Petto¹,

Jesus²,

Vasques³

et al. 2010

Rev. Bras. Hematol. Hemoter.

View full text Add to dashboard Cite

Background The most common hereditary hemoglobin disorder, affecting 20 million individuals worldwide, is sickle cell disease. The vascular obstruction resulting from the sickling of cells in this disease can produce local hypoxemia, pain crises and infarction in several tissues, including the bones, spleen, kidneys and lungs. ObjectiveTo determine red blood group genes in a Brazilian populations.Methods The present study is characterized as a case control study, with the aim of identifying the baseline blood lactate concentration in individuals with hemoglobin SS and SC diseases. One-way ANOVA with the Tukey post-test was used to analyze the results and a p-value < 0.05 was considered significant. Calculations were made using the INSTAT statistical program. The graphs were generated using the ORING program. The study sample was composed of 31 men and women residing in the city of Santo Antônio de Jesus, Bahia, Brazil. The individuals were divided into two groups: Group GC of 16 subjects who did not present with any type of structural hemoglobinopathy; and Group GE composed of 15 individuals with ages between 2 and 35 years old, who had the SS and SC genotypes. Sample analyses were performed with 3 mL of blood during fasting. Results The baseline blood lactate concentration of the SS and SC individuals was higher than that of the control group (p<0.001) with means of 4.86 ± 0.95; 3.30 ± 0.33; 1.31 ± 0.08 IU/L for SS, SC and controls, respectively. This corroborates the initial research hypothesis. Conclusion The baseline blood lactate of SS and SC individuals is 3 to 4 times higher than that of healthy subjects, probably due to the fact that these patients have a metabolic deviation to the anaerobic pathway.

show abstract

“…Affected individuals may develop short, medium, and long-term consequences in several organs and systems that may lead to reduced life expectancy. [1][2][3] These individuals live in a state of chronic hypoxia that increases the frequency of occlusive events, such as brain infarcts, and often lead to pulmonary involvement. They are at increased risk for immune abnormalities, such as complement dysfunction and functional asplenia.…”

mentioning

confidence: 99%

Risk Factors for Acute Chest Syndrome in Patients From Low Socioeconomic Background

Araújo

Araújo-Melo²,

Menezes-Neto³

et al. 2011

Journal of Pediatric Hematology/Oncology

View full text Add to dashboard Cite

A prospective cohort study to assess the risk factors for acute chest syndrome (ACS) in individuals with sickle cell disease was carried out in a referral center from Sergipe, Brazil. A total of 168 SS homozygotic individuals (ages between 12 wk and 26 y) were followed for 12 months. There were 134 admissions of 81 patients. There were 50 events of ACS, which was the second most frequent cause of hospital admission (after pain crisis). One patient died of ischemic stroke during follow up. In bivariate analysis, the following variables showed statistically significant associations with the occurrence of ACS: age less than 5 years, living in rural area, history of previous hospital admission; white blood cell count greater than 10,000/dL; hemoglobin concentration less than 7 g/dL and oxygen saturation ≤ 95% on admission. After controlling for confounding in multivariate logistic regression, only a history of previous admission remained as an independent predictor of ACS (relative risk=4.20; 95% confidence interval: 1.79-9.87; P=0.001). Patients with a positive history of hospital admission are under increased risk and should be monitored closely for prevention and early detection of ACS.

show abstract

Alterações cardiovasculares na anemia falciforme

Cited by 16 publications

References 60 publications

Case Report Benefits of kinesiotherapy and aquatic rehabilitation on sickle cell anemia. A case report

Case Report Benefits of kinesiotherapy and aquatic rehabilitation on sickle cell anemia. A case report

Resting blood lactate in individuals with sickle cell disease

Risk Factors for Acute Chest Syndrome in Patients From Low Socioeconomic Background

Contact Info

Product

Resources

About