Introduction: Psoriasis is a chronic and recurrent dermatological condition characterized by the appearance of red, slightly raised plaques with silvery scales. These plaques feature a sharp edge that distinguishes the affected area from the surrounding normal skin. It is a chronic dermatological condition that can cause feelings of shame, dirt, and untouchability in sufferers, intensified by the fear of isolation and rejection. The relationship between the nervous and immune systems is intertwined, where emotional stress can affect the skin and dermatological conditions can influence the emotional state of the individual. Objective: To explore the psychosocial impact of psoriasis, analyzing its implications for patients' quality of life and well-being, promoting a better understanding and empathetic approach to those living with the condition. Methodology: The study is classified as basic and theoretical research. The literature review was carried out in the search engines Google Scholar, Scopus and Web of Science, using descriptors such as "psoriasis", "emotional health", "psychological impact" and "quality of life". Discussion and Results: The etiology of psoriasis involves complex interactions between the immune system, environmental factors, and genetic predisposition. Studies indicate that dermatological lesions arise due to the release of inflammatory substances, leading to the formation of erythematous-desquamative lesions. Psoriasis is associated with increased cortisol production in response to chronic stress, negatively impacting overall health. The World Health Organization (WHO) recognizes the psychosocial challenges faced by patients, including social stigma and prejudice. Cognitive behavioral therapy is suggested as an effective tool to help patients manage the condition. Additionally, immunobiologicals represent an innovative therapeutic approach for severe or moderate psoriasis, requiring close monitoring due to potential side effects. Final Considerations: Currently, psoriasis has no definitive cure and can manifest itself unexpectedly, causing discomfort. Treatment may involve medications, injections, topical ointments, and dietary changes. However, for many, the skin condition can persist, leading to frustration. Despite being identified as a dysfunction of the immune system, there are still many uncertainties about this disease.