Alterações ultrassonográficas renais e vesicais de ovinos confinados e suplementados com cloreto de amônio

Ferreira, Danilo Otávio Laurenti; Santarosa, Bianca Paola; Belotta, Alexandra Frey; Mamprim, Maria Jaqueline; Silva, Andreza A. da; Dias, Adriano; Chiacchio, Simone Biagio; Gonçalves, Roberto Calderón

doi:10.1590/s0100-736x2014001300018

Cited by 5 publications

(7 citation statements)

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“…Segundo Araújo et al (2009), quanto maior a ingestão de proteína ou nitrogênio não proteico, maior será a ingestão de água, com aumento da produção urinária. Assim, os animais, provavelmente, urinaram um volume maior, excretaram mais creatinina e, consequentemente os níveis séricos diminuíram (Ferreira et al 2014b). A avaliação do volume do débito urinário diário, para comprovar o efeito diuré-tico do CA, no presente estudo, deveria ser realizada pelo uso de gaiola metabólica (Louvandini & Vitti 1994, Stratton-Phelps & House 2004, para mensurar o volume de água ingerido e de urina excretada.…”

Section: Ureia E Creatinina Séricasunclassified

Avaliação clínica, laboratorial e anatomopatológica do sistema urinário de ovinos confinados com ou sem suplementação de cloreto de amônio

et al. 2016

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Resumo: A acidificação urinária com cloreto de amônio (CA) é um método preventivo eficiente em urolitíase obstrutiva em ovinos. Os objetivos deste estudo com ovinos confinados, que receberam dieta concentrada com elevado teor proteico, foram: verificar o efeito da dieta sobre a formação de urólitos e o desenvolvimento da doença; analisar as características macroscópicas e histopatológicas do sistema urinário; relacionar os achados clínicos, laboratoriais e necroscópicos com a presença de urólitos. Utilizaram-se 60 ovinos machos: grupo CA (n=40), 400 mg/kg CA/dia, tratados via oral, por 42 dias consecutivos; grupo-controle (n=20), não tratado. Determinaram-se sete momentos de colheita de amostras com intervalos de sete dias, no total de 56 dias de confinamento. Encontraram-se microcálculos na pelve renal em cinco animais de ambos os grupos. As lesões renais microscópicas mais relevantes foram congestão vascular e necrose tubular. Concluiu-se que a dieta rica em concentrado provocou lesão renal em ambos os grupos, embora sem alterar a função renal, o que foi comprovado em testes pela ureia e creatinina séricas. O cloreto de amônio fornecido ao grupo CA não impediu a calculogênese, mas reduziu sua prevalência em relação ao grupo-controle. Os ovinos do grupo-controle tiveram maior comprometimento renal, pela alta incidência de cristalúria e pela necrose tubular, induzidas pelo consumo da dieta rica em grãos.

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Section: Ureia E Creatinina Séricasunclassified

Avaliação clínica, laboratorial e anatomopatológica do sistema urinário de ovinos confinados com ou sem suplementação de cloreto de amônio

et al. 2016

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“…Renal pelvis dilatation and mild hydronephrosis were noted in some animals with kidney stones, although the renal size was within the normal parameters for the species (Fig. 9) of up to 7.5 cm (20,25) . Alterations in the kidneys were observed in the histopathological examination of the urinary system (Figs 10, 11, and 12), as described in Table 3.…”

Section: Resultsmentioning

confidence: 69%

“…In the left kidney (LK) the transducer was directed cranially below the last rib, due to the presence of the rumen. After identifying the kidneys in two-dimensional mode, the measurement of the renal length in the sagittal section was performed and the architecture of the organ was observed (20) . For the use of pulsed Doppler and measurement of the resistivity index (RI), only the RK was examined, since the visualization of the LK vascularization was complicated by the rumen.…”

Section: Methodsmentioning

confidence: 99%

Clinical and anatomopathological study of urolithiasis in feedlot lambs subjected to diets with different phosphorus concentrations

et al. 2021

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Obstructive urolithiasis is common in farmed sheep and has a multifactorial etiology, but inadequate nutritional management is considered the most relevant condition for its occurrence. The objectives of this study were to verify the influence of two diets with different concentrations of calcium (Ca) and phosphorus (P) on the development of obstructive urolithiasis, and to describe the clinical and anatomopathological findings of the urinary system in sheep. Thirty male crossbred Santa Inês and Ile de France lambs were randomly distributed into two groups: Group 1 (G1, n = 15) - Ca: 1.9:1 P and 0.42% P; Group 2 (G2, n = 15) - Ca: P 1.5:1 and 0.65% P. The diets consisting of Coast-cross hay, soybean meal, wheat, and corn were provided for 90 consecutive days with water ad libitum. After the diagnosis of the disease, the lambs were subjected to clinical and surgical treatment, when necessary. Urolithiasis was detected in 36.7% (11/30) of lambs, 26.7% were asymptomatic and 10% (3/30) had urethral obstruction. A lamb was unobstructed after amputation of the urethral process and urethral catheterization, one died of bladder and uroperitoneum rupture, and another was sacrificed after the failure of perineal urethrostomy and cystostomy. The most frequent renal histopathological changes were vascular congestion, dilation, and tubular degeneration. Proteins in the tubular lumen were more pronounced in G2. The diets were rich in concentrate and had adequate Ca:P ratios, but caused calculogenesis, showing that excess minerals and a small amount of roughage can cause disease in the herd.

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“…The ultrasonographic exam allows an early diagnosis of CKD prior to the presence of azotemia (14). This exam has been widely used to evaluate the genitourinary tract (15)(16)(17). Notwithstanding, in this report, there was no finding by the ultrasonographic exam that could indicate presence of CKD, such as in its architecture abnormality, parenchyma irregularity and altered corticomedullar definition (18).…”

Section: Discussionmentioning

confidence: 96%

Intermittent Hemodialysis, an Alternative Treatment for Ovine With Acute-on-Chronic Kidney Disease.

Guimarães-Okamoto¹,

Albuquerque

Geraldes

et al. 2020

RVZ

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Chronic Kidney Disease (CKD) is a syndrome composed of numerous comorbidities such as the failure of excretion of toxins and nitrogenous compounds from metabolism, as well as the failure to maintain endocrine, water, electrolyte and acid-base homeostasis in all mammals. As it is a non-regenerative and progressive disease, any endogenous or exogenous insults in the organ in question will lead to the intensification of all these mentioned disorders associated with decreased urinary output. Several studies in humans and animals recommend the use of renal replacement therapy, especially in those who already have CKD, and who are in uremic syndrome. This report aims to demonstrate that the use of intermittent hemodialysis (HI) in sheep is a therapeutic alternative in those in renal failure. A six-year-old Bergamasca sheep was presented with lateral decubitus, dyspnea, dark liquid diarrhea, apathy, anorexia and pulmonary crepitation on auscultation. Laboratory tests showed azotemia and electrolyte changes such as hypocalcemia, hypokalemia, hypochloremia, isosthenuria (1,012), pyuria, glycosuria, and a protein: creatinine ratio of 0.88. In ultrasonography, the real resistivity index was above 0.54, being suggestive of loss of renal perfusion. The treatment chosen consisted of electrolytic and fluid replacement, associated with HI. After HI, the sheep showed great clinical and laboratory improvement as expected, however, despite not having survived, the histopathological findings of the necropsy pointed out segments of glomerulosclerosis, thus reinforcing the hypothesis that the animal already had a CKD which was aggravated due to the association of hypovolemia, hypotension by anesthetic drugs and the indiscriminate use of NSAIDs. Despite the death of the sheep, HI again proved to be a therapy of rapid clinical and laboratory improvement of the patient compared to conventional clinical treatment, thus being an important treatment alternative for sheep with a high impact on reproduction, production, and research.

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Alterações ultrassonográficas renais e vesicais de ovinos confinados e suplementados com cloreto de amônio

Cited by 5 publications

References 25 publications

Avaliação clínica, laboratorial e anatomopatológica do sistema urinário de ovinos confinados com ou sem suplementação de cloreto de amônio

Avaliação clínica, laboratorial e anatomopatológica do sistema urinário de ovinos confinados com ou sem suplementação de cloreto de amônio

Clinical and anatomopathological study of urolithiasis in feedlot lambs subjected to diets with different phosphorus concentrations

Intermittent Hemodialysis, an Alternative Treatment for Ovine With Acute-on-Chronic Kidney Disease.

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