Alteration in coagulation profile and incidence of DVT in laparoscopic cholecystectomy

Garg, Pankaj Kumar; Teckchandani, Narinder; Hadke, Niladhar S.; Chander, Jagdish; Nigam, Sonu; Puri, Sunil K.

doi:10.1016/j.ijsu.2008.12.036

Cited by 29 publications

(32 citation statements)

References 15 publications

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“…27 Several investigations showed markers of postoperative hypercoagulability. [30][31][32][33][34][35][36][37] One investigation showed no hemostatic changes in blood draining the lower limbs. 38 More sizeable changes in coagulation activation were observed in the elderly patients.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Embolism and Deep Venous Thrombosis Following Laparoscopic Cholecystectomy

Stein

Matta

Sabra

2013

Clin Appl Thromb Hemost

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There is considerable uncertainty related to the thromboembolic risk after laparoscopic cholecystectomy. Patients with pulmonary embolism (PE), deep venous thrombosis (DVT), or venous thromboembolism (VTE) at hospital discharge following laparoscopic cholecystectomy were identified from the Nationwide Inpatient Sample. From 1998 through 2009, 4 107 430 laparoscopic cholecystectomies were performed. The in-hospital prevalence of PE was 0.15%, DVT was 0.40%, and VTE was 0.53%. The prevalence of PE increased from 0.04% in patients aged 21 to 30 years to 0.31% in patients aged 71 to 80 years. Deaths due to in-hospital PE were 780 (0.02%) of the 4 107 430 laparoscopic cholecystectomies. The rate of death increased with age. The prevalence of VTE following laparoscopic cholecystectomy is low and fatal PE is rare. The risk of VTE increased with age, as did the risk of death in those who had PE. These data may be useful in assessing the use of thromboprophylaxis in patients undergoing laparoscopic cholecystectomy.

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Section: Discussionmentioning

confidence: 99%

Pulmonary Embolism and Deep Venous Thrombosis Following Laparoscopic Cholecystectomy

Stein

Matta

Sabra

2013

Clin Appl Thromb Hemost

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“…Long operating times remain a particular concern for the obese population, in which the risk of complications such as atrial fibrillation, pulmonary embolism, deep venous thrombosis (DVT), and rhabdomyolysis may be increased [24][25][26][27][28][29][30][31]. The risk of atrial fibrillation may be increased by 50%, whereas the reported relative risk of DVT and pulmonary embolism is as high as 3.0, increasing further for patients with a BMI greater than 40 kg/m 2 [30,31].…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic versus open appendectomy for the obese patient: a subset analysis from a prospective, randomized, double-blind study

et al. 2010

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“…Nevertheless, concerns regarding systemic complications and pathophysiology are still being investigated [1]. …”

Section: Introductionmentioning

confidence: 99%

The Effect of Dexmedetomidine on Oxidative Stress during Pneumoperitoneum

Çekiç

Geze

Özkan

et al. 2014

BioMed Research International

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Purpose. This study was intended to investigate the effect of dexmedetomidine on oxidative stress response in pneumoperitoneum established in rats. Methods. Animals were randomized into three groups, group S: with no pneumoperitoneum, group P: with pneumoperitoneum established, and group D: given 100 mcg intraperitoneal dexmedetomidine 30 min before establishment of pneumoperitoneum. Plasma total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) activity were measured 30 min after conclusion of pneumoperitoneum. Results. The mean TOS level was significantly higher in group P than in the other two groups, and the TOS level was significantly higher in group D than in group S (P < 0.05). Plasma TAS level was found to be lower in group P than in the other two groups, and the TAS level was lower in group D than in group S (P < 0.05). Consequently, the OSI was significantly higher in group P than in groups D and S (P < 0.05). Conclusions. Ischemia-reperfusion phenomenon that occurs during pneumoperitoneum causes oxidative stress and consumption of plasma antioxidants. Dexmedetomidine decreases oxidative stress caused by pneumoperitoneum and strengthens the antioxidant defense system.

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Alteration in coagulation profile and incidence of DVT in laparoscopic cholecystectomy

Cited by 29 publications

References 15 publications

Pulmonary Embolism and Deep Venous Thrombosis Following Laparoscopic Cholecystectomy

Pulmonary Embolism and Deep Venous Thrombosis Following Laparoscopic Cholecystectomy

Laparoscopic versus open appendectomy for the obese patient: a subset analysis from a prospective, randomized, double-blind study

The Effect of Dexmedetomidine on Oxidative Stress during Pneumoperitoneum

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