Alteration in serum levels of immunoglobulins in seriously eye-injured long-term following sulfur-mustard exposure

Ghazanfari, Tooba; Mostafaie, Ali; Talebi, Fatemeh; Mahdavi, Mohammad; Yarmohammadi, Mohammad Ebrahim; Askari, Nayere; Moaiedmohseni, Sakine; Majd, Ali Mohammad Mohseni; Mirsharif, Ensie Sadat; Ghazanfari, Zeinab; Hassan, Zuhair Mohammad; Shams, J; Jamali, Davoud; Faghihzadeh, Soghrat

doi:10.1016/j.intimp.2019.105895

Cited by 7 publications

(2 citation statements)

References 21 publications

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“…10,11 A study on eye injuries secondary to SM showed the association of alterations in serum immunoglobulin levels, especially IgG1 and IgG2, with some ocular abnormalities. 12 Ghazanfari et al 13 stated that the level of interleukin-8/CXCL8 in tear film was associated with the intensity of ocular surface injuries. The higher levels of soluble intercellular adhesion molecule 1 and changes in levels of selectins in serum of individuals with severe eye injuries caused by SM were previously demonstrated as a regulatory defense mechanism against the ocular damage by SM.…”

Section: Tissue Inflammationmentioning

confidence: 99%

Mustard Gas–Induced Ocular Surface Disorders: An Update on the Pathogenesis, Clinical Manifestations, and Management

Soleimani

Momenaei

Baradaran‐Rafii

et al. 2022

Cornea

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Purpose: Mustard gas (MG) is a potent blistering and alkylating agent that has been used for military and terrorism purposes. Ocular surface injuries are common after exposure to MG. This review provides an update on the pathophysiology, ocular surface complications, and treatment options for MG-related ocular injuries.Methods: Required information was obtained by reviewing various databases such as Cochrane Library, Google Scholar, and PubMed until March 2022. Data were collected by using keywords: "mustard gas" OR "sulfur mustard" AND "eye" OR "cornea" OR "ocular complication" OR "keratitis" OR "keratopathy" OR "limbal stem cell deficiency" OR "dry eye."Results: Chronic intracellular toxicity, inflammation, and ischemia have been shown to play an essential role in the pathogenesis of MG injury. Ocular surface injuries can have acute, chronic, and most distinctly a delayed-onset presentation leading to various degrees of limbal stem cell deficiency. To date, no treatment has been agreed on as the standard treatment for chronic/delayed-onset MG keratopathy. Based on the authors' experience, we propose a management algorithm for MG-related ocular surface injuries involving optimization of ocular health, anti-inflammatory therapy, and if needed surgical interventions. The management of chronic and delayedonset presentation remains challenging.Conclusions: MG keratopathy is a unique form of chemical injury which can lead to a range of ocular surface pathologies. Long-term anti-inflammatory therapy even in patients with seemingly mild disease may potentially reduce the likelihood of the development of more severe delayed-onset disease.

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Section: Tissue Inflammationmentioning

confidence: 99%

Mustard Gas–Induced Ocular Surface Disorders: An Update on the Pathogenesis, Clinical Manifestations, and Management

Soleimani

Momenaei

Baradaran‐Rafii

et al. 2022

Cornea

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“…Serum levels of IL-1α and FasL were reported to cause different ocular surface abnormalities in sulfur mustard-exposed patients [ 25 ]. The SM-exposure could alter immunoglobulins level compared with healthy controls and the changes of IgG2 and IgG1 levels were associated with some ocular problems [ 26 ].…”

Section: Sulfur Mustardmentioning

confidence: 99%

Occupational Exposures and Environmental Health Hazards of Military Personnel

Geretto

Ferrari

Angelis

et al. 2021

IJERPH

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Background: Military personnels are frequently exposed to environmental pollutants that can cause a variety of diseases. Methods: This review analyzed publications regarding epidemiological and biomonitoring studies on occupationally-exposed military personnels. Results: The exposures include sulfur mustard, organ chlorines, combustion products, fuel vapors, and ionizing and exciting radiations. Important factors to be considered are the lengths and intensities of exposures, its proximity to the sources of environmental pollutants, as well as confounding factors (cigarette smoke, diet, photo-type, healthy warrior effect, etc.). Assessment of environmental and individual exposures to pollutants is crucial, although often omitted, because soldiers have often been evaluated based on reported health problems rather than on excessive exposure to pollutants. Biomarkers of exposures and effects are tools to explore relationships between exposures and diseases in military personnels. Another observation from this review is a major problem from the lack of suitable control groups. Conclusions: This review indicates that only studies which analyzed epidemiological and molecular biomarkers in both exposed and control groups would provide evidence-based conclusions on exposure and disease risk in military personnels.

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Two dimensional proteomic analysis of serum shows immunological proteins exclusively expressed in sulfur mustard exposed patients with long term pulmonary complications

Majd

Alikhani

Naghizadeh

et al. 2020

International Immunopharmacology

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Alteration in serum levels of immunoglobulins in seriously eye-injured long-term following sulfur-mustard exposure

Cited by 7 publications

References 21 publications

Mustard Gas–Induced Ocular Surface Disorders: An Update on the Pathogenesis, Clinical Manifestations, and Management

Mustard Gas–Induced Ocular Surface Disorders: An Update on the Pathogenesis, Clinical Manifestations, and Management

Occupational Exposures and Environmental Health Hazards of Military Personnel

Two dimensional proteomic analysis of serum shows immunological proteins exclusively expressed in sulfur mustard exposed patients with long term pulmonary complications

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