Alteration in sympathoadrenergic activity at rest and during intense exercise despite normal aerobic fitness in late pubertal adolescent girls with type 1 diabetes

Heyman, Elsa; Delamarche, Paul; Berthon, Pierre; Meeusen, Romain; Briard, D.; Vincent, Sophie; Dekerdanet, Marc; Delamarche, Arlette

doi:10.1016/j.diabet.2007.10.003

Cited by 36 publications

(22 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Testing procedure One hour after breakfast, all participants performed an incremental exhaustive exercise on an electrically braked cycle ergometer (Monark: Ergomedic 839E Electronic Test Cycle) as described before by Heyman et al (2007). Heart rate was continuously determined by an electrocardiogram (Schiller AT-102 ECG Machine, California, USA).…”

Section: Anthropometric Measurementsmentioning

confidence: 99%

Obesity and catecholamine responses to maximal exercise in adolescent girls

et al. 2010

View full text Add to dashboard Cite

The aim of this study was to investigate plasma catecholamine [adrenaline (A) and noradrenaline (NA)] concentrations at rest and in response to maximal exercise in three different groups of adolescent girls. According to their body mass index, 34 adolescent girls aged 15-16 years were divided into three groups: a normal weight group (NO) (n = 11), an overweight group (OW) (n = 11) and an obese group (OB) (n = 12). Plasma A and NA concentrations were measured at rest during fasting conditions (A(0) and NA(0)), after a standardized breakfast (A(rest) and NA(rest)) and immediately after an incremental exhaustive exercise (A(EX) and NA(EX)). A (0) and NA(0) were not significantly different among the three groups. However, the A(0)/NA(0) was statistically lower in OB compared to OW and NO. A(EX) and NA(EX) were significantly higher than resting values in the three groups. However, in response to exercise, no significant differences were reported between OB (A(EX) = 2.20 +/- 0.13 nmol/l, NA(EX) = 12.28 +/- 0.64 nmol/l), OW (A(EX) = 2.39 +/- 0.23 nmol/l, NA(EX) = 12.94 +/- 0.93 nmol/l) and NO (A(EX) = 2.52 +/- 0.24 nmol/l, NA(EX) = 12.60 +/- 0.63 nmol/l). In conclusion, our results showed that at rest, in adolescent girls, the responsiveness of the adrenal medulla to the sympathetic nervous activity is lower in OB subjects compared to OW and NO ones. However, in response to maximal exercise, plasma catecholamines are not affected by obesity.

show abstract

Section: Anthropometric Measurementsmentioning

confidence: 99%

Obesity and catecholamine responses to maximal exercise in adolescent girls

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Although multiple data indicated an abnormal activity of the sympathetic nervous system in both diabetic human patients and animals with various experimental models of diabetes, their results are contradictory showing decrease, increase, or no change in plasma catecholamine levels, cardiac norepinephrine content, release, or uptake [3, 4]. The regulation of norepinephrine tissue stores is very complex involving control of expression and/or activity of the key synthesizing enzyme tyrosine hydroxylase, catecholamine exocytotic and nonexocytotic release, its uptake, and metabolism [5–7].…”

Section: Introductionmentioning

confidence: 99%

Alteration of the Cardiac Sympathetic Innervation Is Modulated by Duration of Diabetes in Female Rats

Švíglerová

Mudra

Tonar

et al. 2011

Experimental Diabetes Research

View full text Add to dashboard Cite

To evaluate the sympathetic innervation of the female diabetic heart, resting heart rate and sympathetic tone were assessed in vivo, and effect of tyramine on spontaneous beating rate, norepinephrine atrial concentrations, uptake, and release were determined in vitro in streptozotocin- (STZ-) treated rats and respective controls aged 3 months to 2 years. Resting bradycardia, decreased sympathetic tone, deceleration of spontaneous beating rate, and slightly declining carrier-mediated, but preserved exocytotic norepinephrine release from the atria were found in younger diabetic rats while the reactivity of the right atria to tyramine was not affected with age and disease duration. Diabetic two-year-old animals displayed symptoms of partial spontaneous recovery including normoglycemia, increased plasma insulin concentrations, fully recovered sympathetic tone, but putative change, in releasable norepinephrine tissue stores. Our data suggested that female diabetic heart exposed to long-lasting diabetic conditions seems to be more resistant to alteration in sympathetic innervation than the male one.

show abstract

“…As expected, aerobic [97,[107][108][109][110][111] and to a less important extent, acute high intensity exercise (HIE) [103,110,[112][113][114][115] results in decreased levels of glucose in the T1D patient, which might cause an episode of hypoglycaemia during or after exercise. The effects of resistance training on acute glycaemia are currently unclear.…”

Section: Changes In Blood Glucose Levels After a Single Bout Of Exercisementioning

confidence: 99%

“…PA is generally recommended for its positive effects on glycaemic control, insulin sensitivity and stimulation of muscle glucose uptake [97,98]. Unfortunately, due to the complexity of regulating exogenous insulin in a physiologic manner during exercise, PA often results in episodes of hypoglycaemia or even episodes of hyperglycaemia shortly following or even long after completing exercise [99].…”

Section: Exercise In T1d: Short Term Episodes Of Hypoglycaemia Long mentioning

confidence: 99%

Diabetes Associated Cognitive Decline, is there a Role for Exercise?

Tonoli¹,

Heyman

Roelands³

et al. 2013

J Diabetes Metab

View full text Add to dashboard Cite

Type 1 Diabetes (T1D) can have a significant impact on brain structure and function. This so-called 'diabetesassociated cognitive decline' (DACD) can be attributed to diverse biochemical and neurochemical pathways which are caused by hyperglycaemia, hypoglycaemia, but also by c-peptide and insulin deficiency. Besides the positive effects of exercise on the acute and chronic glycaemic control in T1D patients, a growing number of studies also documented the beneficial influence of exercise on aspects of cognition and performance. Therefore, the purpose of the present narrative review is to discuss the associative aspects between a DACD and its' proposed mechanisms and the potential beneficial effect of exercise on a DACD.

show abstract

Alteration in sympathoadrenergic activity at rest and during intense exercise despite normal aerobic fitness in late pubertal adolescent girls with type 1 diabetes

Cited by 36 publications

References 36 publications

Obesity and catecholamine responses to maximal exercise in adolescent girls

Obesity and catecholamine responses to maximal exercise in adolescent girls

Alteration of the Cardiac Sympathetic Innervation Is Modulated by Duration of Diabetes in Female Rats

Diabetes Associated Cognitive Decline, is there a Role for Exercise?

Contact Info

Product

Resources

About