Alteration in the sexual behaviour of male and female rats after neonatal administration of p-chlorophenylalanine

Hyyppä, Markku T.; Lampinen, Pirkko; Lehtinen, Päivi

doi:10.1007/bf00423192

Cited by 22 publications

(2 citation statements)

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“…Conversely, reducing 5HT activity by neonatal administration of the 5HT synthesis inhibitor p ‐chlorophenylalanine (PCPA) increases male sexual and aggressive behaviour and sexual orientation toward a female in males. It also enhances testosterone‐induced defeminization in females (Hyyppa et al ., 1972; Wilson et al ., 1986; Farabollini et al ., 1988). However, manipulation of brain 5HT activity in the second week pp does not affect the behaviour of adult females that have not been given neonatal testosterone (Wilson et al ., 1986; Wilson et al ., 1991; Albonetti et al ., 1994; Gonzalez et al ., 1996).…”

Section: Introductionmentioning

confidence: 99%

Neonatal 5HT activity antagonizes the masculinizing effect of testosterone on the luteinizing hormone release response to gonadal steroids and on brain structures in rats

Murray

Dakin

Siddiqui

et al. 2004

Eur J of Neuroscience

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Hypothalamic 5HT concentrations are transiently lower in male compared to female Wistar rats in the second week post partum (pp) and our previous findings have shown that pharmacologically potentiating 5HT activity over this period feminizes certain aspects of sexually differentiated behaviours in adult males and androgenized females. In order to investigate whether neonatal testosterone and 5HT interact to influence physiological and morphological brain sexual differences, females, androgenized females and males were treated with the 5HT2 agonist (-) [2,5 dimethoxy-4-iodophenyl]-2-amino propane HCl [(-) DOI], over days 8-16 pp. In androgenized females (250 microg testosterone proprionate, day 2 pp) (-) DOI prevented the delay in vaginal opening, but did not prevent the androgen-induced constant oestrus in females treated with 100 microg TP, day 2 pp. (-) DOI overcame the neonatal androgen effect in suppressing the positive feedback of ovarian steroids in a few males and androgenized females. (-) DOI had a feminizing effect on the volume of the anteroventral periventricular nucleus (normally smaller in males), by significantly increasing its volume in male and androgenized females. It also had a significant antagonistic effect on the testosterone-induced increase in the volume of the sexually dimorphic nucleus of the preoptic area in males and androgenized females. These findings support the view that raised 5HT activity in the second week of life antagonizes the masculinizing effect of neonatal testosterone.

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Section: Introductionmentioning

confidence: 99%

Neonatal 5HT activity antagonizes the masculinizing effect of testosterone on the luteinizing hormone release response to gonadal steroids and on brain structures in rats

Murray

Dakin

Siddiqui

et al. 2004

Eur J of Neuroscience

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“…The intracerebral administration of 5,6dihydroxytryptamine (Da Prada -1972) and 5,7-dihydroxytryptamine (Breese and Cooper -1975;Larsson et al -1978), both of which decrease the brain serotonin level, stimulates copulatory behavior of rats. Further, parachlorophenylalanine, a tryptophan hydroxylase inhibitor, was reported to be effective in the recovery of copulatory behavior in sexually inactive male rats (Sheard -1969, Hyyppa et al -1972Tagliamonte et al -1969). These results clearly indicate that elevated brain serotonin levels inhibit male sexual behavior.…”

Section: Discussionmentioning

confidence: 99%

The Spinal Monoaminergic Systems Relating to Ejaculation

et al. 2009

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In the previous paper (Kimura et al. -1982) the authors reported on the distribution on noradrenaline, dopamine, serotonin and 5-hydroxyindole acetic acid in the spinal cord and recognized that changes of monoamine levels occurred in the spinal cord by administration of various psychotropic drugs and that the spinal catecholamines might have direct functional significance in ejaculation.In the present study the effect on ejaculation of administration of 5-hydroxytryptophan (5-HTP), the direct precursor of serotonin with pretreatment with Ro 44602, a peripheral decarboxylase inhibitor, was investigated in an attempt to elucidate the role of the spinal serotonergic system in ejaculation. Materials and MethodsAnimals: Twenty-seven male adult mongrel dogs weighing 10-1 5 Kg were used for the study. The dogs were selected 3 days prior to the start of administration for the following drugs and those showing both normal erection and ejaculation by manual stimulation of the penis were admitted to the study. Dncgs: The drugs used in the present study were Ro 4-4602 (Japan Roche) and L-5hydroxytryptophan (L-5HTP) (Kyowa Hakko Co.). Ro 4-4602 was administered as a solution in saline and L-5HTP as a suspension in 0.5% tween 80. These drugs were administered intraperitoneally. Procedure: Penile erection and ejaculation were induced in these animals by manual stimulation of the penis as described in the previous papers (Kimura et al. -1976(Kimura et al. - ,1977(Kimura et al. - and 1982. The contents of noradrenaline, dopamine, serotonin and 5-hydroxyindole acetic acid were determined by the method reported previously (Kimura et al. -1976 and. Results Effect ofRo 4-4602 plus L-SHTP on ejaculation:Adult dogs with normal erection and ejaculation were administered 12.5,25 or 50 rng/Kg of L-5HTP with pretreatment with 20 mg/Kg of Ro 44602. One hour after the administration ejaculation was suppressed in 6 of 8 dogs receiving 12.5 mg/Kg, in all dogs given 25 mg/Kg and in 10 of 11 dogs given 50 mg/Kg of L-5 HTP. Penile erection was maintained in most of dogs so treated ( Table 1). Changes in noradrenaline (NA), dopamine (DA), serotonin (5-HT) and 5-hydroxyindoleKey words: Ejaculationspinal monoaminesserotonindopaminenoradrenaline -S-hydroxyindole acetic acid andrologia 15 (1983)

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Ontogeny of monoamine neurons in the locus coeruleus, raphe nuclei and substantia nigra of the rat

Lauder

Bloom

1975

J of Comparative Neurology

221

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Synaptogenesis was studied in the monoamine (MA) cell groups locus coeruleus (LC), dorsal and medial raphe nuclei (RN) and substantia nigra, zona compacta (SN) between day 18 of gestation and postnatal day 60 using ethanolic phosphotungstic acid (E-PTA) to visualize synaptic profiles. Nuclear area, and cellular packing density (inversely proportional to area of neuropil) were also determined. As determined using the E-PTA method, synaptogenesis begins in the neuropil of the SN first, on or before 18 days of gestation, and in the LC and RN at 19 days. Synaptogenesis on MA cell perikarya is first observed in the SN, on or before 18 days, and in the LC and RN at 20 days. The onset of somatic synaptogenesis coincides with the beginning of nuclear growth and development of the neuropil (decrease in cellular packing density) in all MA cell areas, raising the possibility of common factors in the initiation of these processes. Nonsynaptic contacts precede the appearance of synaptic profiles both in the neuropil and on the somata of the MA cells of the LC, RN and SN, and may represent precursors of mature synapses or desmosome-like contacts. Somatosomatic nonsynaptic contacts occur only prenatally between adjacent MA neurons in the LC, RN and SN. Although some synaptogenesis occurs prenatally in these MA cell groups (indiciating that these parts of the MA circuitry may be functional before birth), most of this synaptogenesis occurs postnatally and continues into adulthood. Since such synaptogenesis does not begin until 2-4 days prior to birth, whereas these neurons and their processes exhibit MA fluorescence as early as 12-14 days of gestation, they apparently are capable of synthesizing transmitter and proliferating terminals before they themselves are innervated.

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Alteration in the sexual behaviour of male and female rats after neonatal administration of p-chlorophenylalanine

Cited by 22 publications

References 21 publications

Neonatal 5HT activity antagonizes the masculinizing effect of testosterone on the luteinizing hormone release response to gonadal steroids and on brain structures in rats

Neonatal 5HT activity antagonizes the masculinizing effect of testosterone on the luteinizing hormone release response to gonadal steroids and on brain structures in rats

The Spinal Monoaminergic Systems Relating to Ejaculation

Ontogeny of monoamine neurons in the locus coeruleus, raphe nuclei and substantia nigra of the rat

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