Alteration of cell junctions during viral infection

Dong, Dan; Xie, Wei; Liu, Min

doi:10.1111/1759-7714.13344

Cited by 22 publications

(24 citation statements)

References 97 publications

(174 reference statements)

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“… 1 , 2 The apical TJ is a dynamic structure and undergoes continuous turnover. 3 It includes three main subsets of proteins: 1. The claudin family, comprising claudin-1 through 27 in mouse and human; 4 2.…”

Section: Introductionmentioning

confidence: 99%

Airway tight junctions as targets of viral infections

et al. 2021

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The apical junctional complexes (AJCs) of airway epithelial cells are a key component of the innate immune system by creating barriers to pathogens, inhaled allergens, and environmental particles. AJCs form between adjacent cells and consist of tight junctions (TJs) and adherens junctions (AJs). Respiratory viruses have been shown to target various components of the AJCs, leading to airway epithelial barrier dysfunction by different mechanisms. Virus-induced epithelial permeability may allow for allergens and bacterial pathogens to subsequently invade. In this review, we discuss the pathophysiologic mechanisms leading to disruption of AJCs and the potential ensuing ramifications. We focus on the following viruses that affect the pulmonary system: respiratory syncytial virus, rhinovirus, influenza viruses, immunodeficiency virus, and other viruses such as coxsackievirus, adenovirus, coronaviruses, measles, parainfluenza virus, bocavirus, and vaccinia virus. Understanding the mechanisms by which viruses target the AJC and impair barrier function may help design therapeutic innovations to treat these infections.

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Section: Introductionmentioning

confidence: 99%

Airway tight junctions as targets of viral infections

et al. 2021

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“…Destruction of cilium-related proteins can damage the vascular barrier, which may be mediated by HH, Notch, Wnt, and other signaling pathways. It is possible that cilium defects cause damage to intercellular junctions and paracellular transport, such as tight junctions and adherens junctions, which are important in vascular barriers ( Xie et al, 2017 ; Dong et al, 2020 ). Alternatively, cilium defects may cause blood vessels to inhibit the recruitment of vascular mural cells, such as pericytes and smooth muscle cells, leading to damage to the vascular barrier ( Chen et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Functions of Endothelial Cilia in the Regulation of Vascular Barriers

Zhou

2020

Front. Cell Dev. Biol.

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The vascular barrier between blood and tissues is a highly selective structure that is essential to maintain tissue homeostasis. Defects in the vascular barrier lead to a variety of cardiovascular diseases. The maintenance of vascular barriers is largely dependent on endothelial cells, but the precise mechanisms remain elusive. Recent studies reveal that primary cilia, microtubule-based structures that protrude from the surface of endothelial cells, play a critical role in the regulation of vascular barriers. Herein, we discuss recent advances on ciliary functions in the vascular barrier and suggest that ciliary signaling pathways might be targeted to modulate the vascular barrier.

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“…Viruses destroy cell junctions to invade the host (65). Also, another role of gap junctions reported in viral infection, is the amplification of antiviral signaling in neighbouring cells.…”

Section: Protein-protein Interactions Of Sars-cov-2 Proteins With Hicsmentioning

confidence: 99%

Deciphering the interactions of SARS-CoV-2 proteins with human ion channels using machine learning-based method

Munjal

Sapra

Goyal

et al. 2021

Preprint

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the worldwide COVID-19 pandemic which began in 2019. It has a high transmission rate and pathogenicity leading to health emergencies and economic crisis. Recent studies pertaining to the understanding of the molecular pathogenesis of SARS-CoV-2 infection exhibited the indispensable role of ion channels in viral infection inside the host. Moreover, machine learning-based algorithms are providing higher accuracy for host-SARS-CoV-2 protein-protein interactions (PPIs). In this study, predictions of PPIs of SARS-CoV-2 proteins with human ion channels (HICs) were performed using PPI-MetaGO algorithm. The PPIs were predicted with 82.71% accuracy, 84.09% precision, 84.09% sensitivity, 0.89 AUC-ROC, 65.17% MCC score and 84.09% F1 score. Thereafter, PPI networks of SARS-CoV-2 proteins with HICs were generated. Furthermore, biological pathway analysis of HICs interacting with SARS-CoV-2 proteins showed the involvement of six pathways, namely inflammatory mediator regulation of TRP channels, insulin secretion, renin secretion, gap junction, taste transduction and apelin signaling pathway. The inositol 1,4,5-trisphosphate receptor 1 (ITPR1) and transient receptor potential cation channel subfamily A member 1 (TRPA1) were identified as potential target proteins. Various FDA approved drugs interacting with ITPR1 and TRPA1 are also available. It is anticipated that targeting ITPR1 and TRPA1 may provide a better therapeutic management of infection caused by SARS-CoV-2. The study also reinforces the drug repurposing approach for the development of host directed antiviral drugs.

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Alteration of cell junctions during viral infection

Cited by 22 publications

References 97 publications

Airway tight junctions as targets of viral infections

Airway tight junctions as targets of viral infections

Functions of Endothelial Cilia in the Regulation of Vascular Barriers

Deciphering the interactions of SARS-CoV-2 proteins with human ion channels using machine learning-based method

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