Alteration of choroidal vascular structure in diabetic macular edema

Kase, Satoru; Endo, Hiroaki; Takahashi, Mitsuo; Ito, Yuki; Saito, Michiyuki; Yokoi, Masahiko; Katsuta, Satoshi; Sonoda, Shozo; Sakamoto, Taiji; Ishida, Susumu; Kase, Manabu

doi:10.1007/s00417-020-04604-z

Cited by 14 publications

(16 citation statements)

References 27 publications

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“…In our present study, the LA values in the cystoid DME group were lower than in the controls, whereas the eyes with diffuse DME and DME with subretinal fluid had higher SA values than the control eyes. The CVI values did not differ significantly according to the DME type, which is in line with the results reported by Gupta et al [ 34 ] and Kase et al [ 35 ]. While we found between-group differences in LA, SA, and TCA values for eyes with various DME types, none of them had a significant effect on CVI.…”

Section: Discussionsupporting

confidence: 92%

“…Similar to our present study, those researchers also observed choroidal thinning over the entire posterior pole [ 16 ]. However, some authors have reported an increase in choroidal thickness during DME [ 15 , 25 , 34 , 35 , 42 ], while others have found no significant association between the choroidal thickness and DME [ 18 , 24 , 26 , 43 ].…”

Section: Discussionmentioning

confidence: 99%

“…Still, little is known about the association between choroidal parameters and the type of DME [ 27 , 34 , 35 ]. Our present study did not show significant differences in the choroidal thickness and volume in eyes with various DME types.…”

Section: Discussionmentioning

confidence: 99%

“…Hence, CVI can be considered a relatively stable parameter to evaluate changes in the choroidal vasculature [ 33 ]. Unlike the relationship between choroidal thickness and DME, which has been the subject of many previous studies [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ], only a few authors have analysed choroidal thickness depending on DME type [ 27 , 34 , 35 ] and even fewer have studied CVI in various DME types [ 34 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

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Quantitative Assessment of Choroidal Parameters in Patients with Various Types of Diabetic Macular Oedema: A Single-Centre Cross-Sectional Analysis

Dmuchowska

Sidorczuk

Pieklarz

et al. 2021

Biology

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Diabetic macular oedema (DME) is an outcome of multiple, complex and not fully understood mechanisms. The aim of this study was to define the role of choroidopathy in the pathogenesis of various DME types. The retrospective cross-sectional single-centre study included 140 eyes from 105 patients with DME and 76 eyes from 52 non-diabetic controls. The eyes were stratified according to the type of DME: cystoid, diffuse, and with subretinal fluid. Optical coherence tomography-based choroidal parameters: thickness, volume, choroidal vascularity index (CVI), luminal area (LA), stromal area (SA), and total choroidal area (TCA) were compared. Eyes with DME, regardless of the type thereof, had lower choroidal thickness, volume, and CVI values than the controls. Further, the eyes with some specific DME types differed significantly from the controls in terms of LA and SA. While the eyes with various DME types did not differ significantly in terms of their choroidal thickness, volume and CVI, some between-group differences were found in LA, SA and TCA. Diabetic choroidopathy seems to play a role in the development of DME but is less likely involved in the pathogenesis of specific types thereof.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Quantitative Assessment of Choroidal Parameters in Patients with Various Types of Diabetic Macular Oedema: A Single-Centre Cross-Sectional Analysis

Dmuchowska

Sidorczuk

Pieklarz

et al. 2021

Biology

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“…On the contrary, other investigators have suggested that choroidal blood volume, flow and velocity decreases in diabetic eyes with DMO, which may lead to hypoxia of the outer retina, thereby leading to increase in VEGF levels [ 90 , 91 , 92 ]. The choroid in DMO is also not affected by systemic factors such as increased HbA1c, blood pressure, cholesterol or abnormal renal function [ 93 ]. At the present time, there is insufficient evidence to suggest that changes in central choroidal thickness, subfoveal choroidal thickness or choroidal vascularity index influence visual outcome in DMO [ 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 ].…”

Section: Objective Factorsmentioning

confidence: 99%

Indicators of Visual Prognosis in Diabetic Macular Oedema

Sen

Ramasamy

Sivaprasad

2021

JPM

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Diabetic macular oedema (DMO) is an important cause of moderate vision loss in people with diabetes. Advances in imaging technology have shown that a significant proportion of patients with DMO respond sub-optimally to existing treatment options. Identifying associations and predictors of response before treatment is initiated may help in explaining visual prognosis to patients and aid the development of personalized treatment strategies. Imaging features, such as central subfoveal thickness, photoreceptor integrity, disorganization of retinal inner layers, choroidal changes, and macular perfusion, have been reported to be prognostic factors of visual acuity (VA) in DMO. In this review we evaluated each risk factor to understand their relative importance in visual prognostication of DMO eyes post-treatment. Although individually, some of these factors may not be significant predictors, in combination they may form phenotypes that can inform visual prognosis. Stratification based on these phenotypes needs to be developed to progress to personalized medicine for DMO.

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Retinal and Choroidal Alterations in Diabetic Retinopathy Treatment using Subthreshold Panretinal Photocoagulation with Endpoint Management Algorithm: A Secondary Analysis of a Randomized Clinical Trial

Zhou

et al. 2023

Ophthalmol Ther

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Alteration of choroidal vascular structure in diabetic macular edema

Cited by 14 publications

References 27 publications

Quantitative Assessment of Choroidal Parameters in Patients with Various Types of Diabetic Macular Oedema: A Single-Centre Cross-Sectional Analysis

Quantitative Assessment of Choroidal Parameters in Patients with Various Types of Diabetic Macular Oedema: A Single-Centre Cross-Sectional Analysis

Indicators of Visual Prognosis in Diabetic Macular Oedema

Retinal and Choroidal Alterations in Diabetic Retinopathy Treatment using Subthreshold Panretinal Photocoagulation with Endpoint Management Algorithm: A Secondary Analysis of a Randomized Clinical Trial

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