2016
DOI: 10.1016/j.cyto.2016.01.022
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Alteration of cytokine profile following hemorrhagic shock

Abstract: Hemorrhage is one of the leading causes of death in patients with trauma. We recently demonstrated that resveratrol can improve cardiac function and prolong life following severe hemorrhagic injury (HI) in a rat model. The present work is focused on determining changes in NF-κb dependent gene expression in the heart and the systemic cytokine milieu following HI and the effect of resveratrol treatment. The results indicate an increase in phosphorylated NF-κb in the heart with a concomitant increase in the expre… Show more

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Cited by 19 publications
(22 citation statements)
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“…The increased expression of HMGB1 in splenocytes is consistent with the systemic inflammatory response observed following HI. Our lab and others have reported the increased level of plasma cytokines immediately after HI (34, 49). Some of these cytokines begin to appear as early as one hour after HI (34, 38, 50, 51).…”
Section: Discussionmentioning
confidence: 60%
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“…The increased expression of HMGB1 in splenocytes is consistent with the systemic inflammatory response observed following HI. Our lab and others have reported the increased level of plasma cytokines immediately after HI (34, 49). Some of these cytokines begin to appear as early as one hour after HI (34, 38, 50, 51).…”
Section: Discussionmentioning
confidence: 60%
“…Our lab and others have reported the increased level of plasma cytokines immediately after HI (34, 49). Some of these cytokines begin to appear as early as one hour after HI (34, 38, 50, 51). The initial inflammatory response is likely to be a repair process to balance cellular homeostasis, but persistent exacerbated inflammation following the initial insult contributes to organ dysfunction (5, 52, 53).…”
Section: Discussionmentioning
confidence: 60%
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“…In several rodent models of HSR, the cellular benefits of resveratrol clearly correlate with improved organ function up to 24 h postshock. When given during resuscitation, resveratrol decreased the expression of circulating inflammatory mediators and downregulated the expression of cytokines, chemokines, and adhesion molecules in multiple organs, including the liver, lung, intestine, and heart . Importantly, the decrease in proinflammatory mediators correlated with fewer neutrophils migrating into tissues and decreased tissue damage .…”
Section: Resveratrol and Inflammation In Hsrmentioning
confidence: 97%