Alteration of cytokines in saliva of children with caries and obesity

Santos, Saúl Ramírez-de los; López-Pulido, Edgar Iván; Medrano-González, Isabel Del Carmen; Becerra-Ruiz, Julieta Saraí; Alonso-Sánchez, Carmen Celina; Vázquez-Jiménez, Sonia Isela; Guerrero-Velázquez, Celia; Guzmán-Flores, Juan Manuel

doi:10.1007/s10266-020-00515-x

Cited by 15 publications

(21 citation statements)

References 31 publications

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“…Of these, 18 publications met the eligibility criteria and were included in this review. [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] The overall characteristics of included studies are presented in Table 2. [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] All the included studies had a cross-sectional design, except 1, 30 which had a longitudinal design.…”

Section: Resultsmentioning

confidence: 99%

“…[18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] The overall characteristics of included studies are presented in Table 2. [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] All the included studies had a cross-sectional design, except 1, 30 which had a longitudinal design. Studies were conducted in 8 of the 32 states in Mexico (Figure 2).…”

Section: Resultsmentioning

confidence: 99%

“…Reported results are presented by age group in Table 3. [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] Overall, the results are inconclusive within and across different age groups. Some studies found no association between BMI and oral health indexes or prevalence of caries.…”

Section: Resultsmentioning

confidence: 99%

“…Overall, 10 of the 18 included studies were of high quality, [23][24][25][26][27][28][29][30]33,34 4 were of unclear quality, 18,21,31,32 and another 4 were of low quality. 19,20,22,35 The population inclusion and exclusion criteria were not reported clearly in 2 studies.…”

Section: Quality Of the Included Studiesmentioning

confidence: 99%

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Obesity and oral health in Mexican children and adolescents: systematic review and meta-analysis

et al. 2022

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Context A relationship between obesity and poor oral health has been reported. Objective To investigate the association between overweight/obesity and oral health in Mexican children and adolescents. Data Sources A literature search was conducted of 13 databases and 1 search engine for articles published from 1995 onward. Data Analysis A total of 18 publications were included. Evidence was inconclusive and varied according to sociodemographic factors or outcome measuring tools. The Decayed, Missing, and Filled Teeth and Filled Teeth Surfaces indices and the decayed extracted filled teeth index outcomes were included in a random effects model meta-analysis. Pooled estimates showed no statistically significant oral health differences (measured via the decayed extracted filled teeth or the Decayed, Missing, and Filled Teeth Surfaces indexes) among body mass index (BMI) categories. However, pooled estimates of 6 studies showed that children with higher BMI had worse oral health in permanent teeth (measured via the Decayed Missing Filled Teeth Index) than children with lower BMI (overall mean difference, –0.42; 95%CI, –0.74, –0.11). Conclusion Whether there is an association between poor oral health and high BMI is inconclusive; however, both co-exist among Mexican children. Therefore, health promotion and prevention efforts should address common risk factors and broader risk social determinants shared between noncommunicable diseases.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Quality Of the Included Studiesmentioning

confidence: 99%

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Obesity and oral health in Mexican children and adolescents: systematic review and meta-analysis

et al. 2022

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“…However, these patients are still at risk of developing severe proinflammatory complications due to COVID-19 and on top of this most children with T2D are associated with obesity (55). Furthermore, high levels of proinflammatory cytokines in obese children have been reported such as IL-6 and IL-15 (56). This in fact could worsen the disease prognosis among these patients by increasing the risk of cytokines damaging surge.…”

Section: Children Who Have Been Confirmed As Having the Covid-19 Infection Either Mild Or Asymptomatic -Why?mentioning

confidence: 99%

Impact of COVID-19 on Children and Young Adults With Type 2 Diabetes: A Narrative Review With Emphasis on the Potential of Intermittent Fasting as a Preventive Strategy

Elmajnoun

Faris

Uday³

et al. 2021

Front. Nutr.

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Background: The world is still struggling to control the COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The level of uncertainty regarding the virus is still significantly high. The virus behaves differently in children and young adults. Most children and adolescents are either asymptomatic or have mild symptoms. They generally have a very good prognosis. However, it is not well-known whether children and young adults with type 2 diabetes are at risk of getting a severe infection of COVID-19. Many Muslim children with type 2 diabetes have been performing dawn to dusk fasting during the month of Ramadan, before and during the COVID-19 pandemic, and the impact of this on their health has not been well investigated. Previous studies in adults have suggested that intermittent fasting may be beneficial in different ways including reversal of type 2 diabetes and prevention of COVID-19 infection.Objective: The primary aim of this narrative review is to summarise the impacts of the COVID-19 pandemic on children and young adults with type 2 diabetes, and to identify the knowledge gaps in the literature. It also explores the potential of intermittent fasting in reversing the pathogenesis of diabetes and highlighting how this approach could prevent these patients from developing chronic complications.Methods: This narrative review has been produced by examining several databases, including Google Scholar, Research Gate, PubMed, Cochrane Library, MEDLINE (EBSCO), and Web of Science. The most common search terms used were “COVID-19 AND Children”, “SARS-CoV-2 AND/OR Children”, “COVID-19 AND Diabetes” “COVID-19 Epidemiology”, “COVID-19 AND Ramadan fasting”, “COVID-19 and Intermittent fasting.” All the resources used are either peer-reviewed articles/reports and/or official websites of various media, governmental and educational organisations.Results: Having reviewed the currently limited evidence, it has been found that the incidence of COVID-19 among children with type 2 diabetes seems to be not much different from children without diabetes. However, these patients are still vulnerable to any infection. Several studies have reported that prevention programmes such as intermittent fasting are effective to protect these groups of patients from developing any complications. Moreover, observing Ramadan fasting as a type of intermittent fasting could be beneficial for some children with established diabetes, prediabetes and people at risk.Conclusion: Children and young adults with type 2 diabetes are not at risk of severe COVID-19 infection as the case in adults with diabetes. More research is needed to identify the impact of COVID-19 and to investigate the efficacy and safety of intermittent fasting, including Ramadan fasting, among these age groups. Implementing these cost-effective programmes may have a great impact in minimising the incidence of diabetes. Moreover, this could be effective particularly at prediabetes stage by preventing these people from going onto develop type 2 diabetes and taking medications for the rest of their life and protecting people from complications linked to disease and infection.

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Is there an association between salivary immune and microbial profile with dental health in systematically healthy children?

Davidovich,

Sarne,

Shmueli

et al. 2024

Clin Oral Invest

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Objective This study aimed to characterize the inflammatory profile of systemically healthy children’s saliva and its association with clinical diagnoses of caries and gingival inflammation. Materials and methods Unstimulated saliva was collected from 100 children before clinical dental examinations. The saliva samples were analyzed for total protein and specific inflammatory cytokines (IL-10, IL-8, IL-6, and TNFα) with Bradford and ELISA assays, respectively. Salivary bacteria were quantified using a quantitative real-time polymerase chain assay. The salivary values were then correlated with age, DMFT index, plaque index (PI), and gingival index (GI). Results The mean age of the cohort was 8.08 ± 0.23 years with 49% females, the mean DMF of the cohort was 2.64 ± 0.31, the mean GI was 0.51 ± 0.06, and the mean PI was 1.33 ± 0.07. Significant correlations were found between PI with DMFT and GI. Children with DMFT > 2 had significantly higher levels of IL-8 compared with children with DMFT ≤ 2. IL-6 and TNFα were significantly higher among children with PI > 1 than among children with PI ≤ 1. Conclusions Salivary cytokine were found to be associate with clinical parameters as DMFT and PI, thus may be a potential tool that reflects dental health status. Clinical relevance The presence of salivary cytokines in children may reflect evaluation of dental caries and oral inflammation.

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Alteration of cytokines in saliva of children with caries and obesity

Cited by 15 publications

References 31 publications

Obesity and oral health in Mexican children and adolescents: systematic review and meta-analysis

Obesity and oral health in Mexican children and adolescents: systematic review and meta-analysis

Impact of COVID-19 on Children and Young Adults With Type 2 Diabetes: A Narrative Review With Emphasis on the Potential of Intermittent Fasting as a Preventive Strategy

Is there an association between salivary immune and microbial profile with dental health in systematically healthy children?

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