Alteration of Endogenous Catecholamine Metabolism by Ethanol Ingestion.

Davis, Virginia E.; Cashaw, Jesse L.; Huff, James A.; Brown, Harold; Nicholas, Nickie L.

doi:10.3181/00379727-125-32298

Cited by 36 publications

(16 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The overall effects of ethanol on the metabolism of norepinephrine are well known (23,24). Small amounts of ethanol increase the excretion of HMPG and decrease that of VMA.…”

Section: Discussionmentioning

confidence: 99%

Human class I alcohol dehydrogenases catalyze the oxidation of glycols in the metabolism of norepinephrine.

Mårdh¹,

Luehr²,

Vallée³

1985

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…The overall effects of ethanol on the metabolism of norepinephrine are well known (23,24). Small amounts of ethanol increase the excretion of HMPG and decrease that of VMA.…”

Section: Discussionmentioning

confidence: 99%

Human class I alcohol dehydrogenases catalyze the oxidation of glycols in the metabolism of norepinephrine.

Mårdh¹,

Luehr²,

Vallée³

1985

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…Davis et al (11,19) reported that 3 times adminis tration of 60 ml of alcohol to 2 healthy men caused a decrease of urinary excretion of VMA and an increase of MHPG. Giltow et al (20) found an elevation of urinary MHPG and a decrease of VMA after administration of alcohol for 7 days to a normal man.…”

Section: Discussionmentioning

confidence: 99%

Acetaldehyde-mediated alcohol sensitivity and elevation of plasma catecholamine in man.

Adachi

Mizoi

1983

Jpn.J.Pharmacol

View full text Add to dashboard Cite

Abstract-According to the presence and absence of aldehyde dehydrogenase (ALDH) I isozyme which had low K,,, for acetaldehyde, subjects were divided into two groups: the former, the usual ALDH group and the latter, the unusual ALDH one. Blood alcohol and acetaldehyde levels, plasma norepinephrine and epinephrine levels, and urinary excretion of norepinephrine, epinephrine, dopamine, vanillylmandelic acid (VMA) and 3-methoxy-4-hydroxyphenylglycol (MHPG) were determined; and the differences in these values and cardiovascular symptoms after alcohol intake between the two groups were investigated. Fifty-six healthy male volunteers were studied after they ingested 0.4 g of alcohol per kg of body weight. There was no difference in blood alcohol level between the two groups. In the unusual ALDH group, facial flushing, increase of pulse rate and decrease in diastolic blood pressure associated with accumulation of blood acetaldehyde were shown. In addition, rises in plasma catecholamine and urinary ex cretion of catecholamine were also observed. However, in the usual ALDH group, in which blood acetaldehyde level scarcely increased, these changes were not significant. The alteration of catecholamine metabolism, decrease in urinary VMA and increase in urinary MHPG was recognized in both groups.

show abstract

“…Furthermore, ethanol intoxication did not generate a rise in epinephrine at 140-300 min and in norepinephrine at 20-60 and 140-300 min after exercise. Ethanol has been shown to elevate catecholamine concentrations when exercise is not involved (1,34), and ethanol metabolism can increase circulating catecholamine concentrations by decreasing the hepatic NAD-to-NADH ratio (7,8) and result in decreased catecholamine clearance. In addition to this mechanism, the response may also consist of a centrally mediated component.…”

Section: Discussionmentioning

confidence: 99%

Effect of acute postexercise ethanol intoxication on the neuroendocrine response to resistance exercise

Koziris

Kraemer

Gordon

et al. 2000

Journal of Applied Physiology

View full text Add to dashboard Cite

don, Thomas Incledon, and Howard G. Knuttgen. Effect of acute postexercise ethanol intoxication on the neuroendocrine response to resistance exercise. J. Appl. Physiol. 88: 165-172, 2000.-This investigation was conducted to determine the effect of postexercise ethanol intoxication (21.97 Ϯ 1.09 mmol/l blood) on the response of selected aspects of the neuroendocrine system to a resistance exercise (Ex) session. Nine resistance-trained men (25.0 Ϯ 1.4 yr, 179.4 Ϯ 3.4 cm, 79.7 Ϯ 3.3 kg) were used to compare three 3-day treatments: control, Ex, and ethanol after exercise (ExEt). Blood was collected serially from an antecubital vein before exercise, immediately after exercise, and for pooled analysis at 20-40 (2 samples), 60-120 (4 samples), and 140-300 (9 samples) min after exercise on day 1 and in the morning (2 samples each) on days 2 and 3. Ethanol did not increase circulating epinephrine, norepinephrine, or cortisol concentration (Cort) above Ex elevations. At 60-120 min, only ExEt Cort was greater than control Cort. Concentrations of testosterone, luteinizing hormone, and corticotropin were not affected by either treatment. It is concluded that, although this blood ethanol concentration is insufficient to acutely increase Cort above that caused by Ex alone, it appears that ethanol may have a prolonged effect beyond the Ex response. This blood ethanol concentration does not further stimulate the sympathoadrenal system during the postexercise response.anabolic; catabolic; alcohol; lactate; stress response THE EFFECTS OF ETHANOL vary and can depend on the extent of its consumption and environmental context. In addition to its acute effects, ethanol can impede physical performance when its consumption is of a chronically abusive nature, i.e., alcoholism. It has been known for some time that individuals diagnosed with alcohol dependence have displayed various degrees of muscle damage and weakness (26, 37).The neuroendocrine system, and specifically the interaction of various anabolic (14) and catabolic hormones (2, 19), is part of the response to resistance exercise. This system, which has a role in the maintenance and adaptation of muscular tissue and strength, is also among the many systems affected by acute (1, 27, 32) and chronic ethanol abuse (28,32).With regard to the pituitary-adrenocortical axis, increased postexercise cortisol concentrations have been shown consequent to acute resistance exercise (15, 17). Ethanol ingestion results in elevated circulating cortisol concentrations, and there is apparently a doserelated effect (13, 32). Although there is evidence to suggest that the effect of ethanol on this axis occurs via corticotropin-releasing hormone (CRH) secretion from hypothalamic neurons (35) via adrenergic stimulation of higher centers (41), there is evidence to indicate that ethanol's effect is instead mediated via an increase in ACTH release from the anterior pituitary gland (18,33).In the pituitary-gonadal axis of men, testosterone is thought to have a role in the adaptation to resistance exercis...

show abstract

Alteration of Endogenous Catecholamine Metabolism by Ethanol Ingestion.

Cited by 36 publications

References 0 publications

Human class I alcohol dehydrogenases catalyze the oxidation of glycols in the metabolism of norepinephrine.

Human class I alcohol dehydrogenases catalyze the oxidation of glycols in the metabolism of norepinephrine.

Acetaldehyde-mediated alcohol sensitivity and elevation of plasma catecholamine in man.

Effect of acute postexercise ethanol intoxication on the neuroendocrine response to resistance exercise

Contact Info

Product

Resources

About