Alteration of fecal microbiome and metabolome by mung bean coat improves diet-induced non-alcoholic fatty liver disease in mice

Hou, Dianzhi; Tang, Jian; Huan, Meili; Liu, Fang; Zhou, Sumei; Shen, Qun

doi:10.1016/j.fshw.2022.04.023

Cited by 28 publications

(13 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Muribaculum genus has been observed to be decreased in HFD mice and is related to body weight regulation [ 62 ]. Norank_f_Muribaculaceae is positively correlated with a reduction in liver steatosis and is an important SCFA-producing bacterium [ 63 ]. The abundance of Prevotellaceas_UCG_001 was negatively correlated with GLU, TC, and HDL [ 64 ].…”

Section: Discussionmentioning

confidence: 99%

The Ameliorative Effect and Mechanisms of Ruditapes philippinarum Bioactive Peptides on Obesity and Hyperlipidemia Induced by a High-Fat Diet in Mice

Song

Cai

Wang³

et al. 2022

Nutrients

View full text Add to dashboard Cite

In this study, bioactive peptides (RBPs) from Ruditapes philippinarum were prepared by fermentation with Bacillus natto and the effect and mechanisms of RBPs on obesity and hyperlipidemia were explored in mice. We found that RBPs significantly reduced body weight, adipose tissue weight, accumulation of hepatic lipids, and serum levels of total cholesterol (CHO), triglyceride (TG), and low-density lipoprotein (LDL). Mechanistic studies showed that RBPs up-regulated the hepatic expression of genes related to lipolysis, such as hormone-sensitive lipase (HSL), phosphorylated AMP-activated protein kinase (p-AMPK), and peroxisome proliferator-activated receptors α (PPARα), and down-regulated the expression of peroxisome proliferator-activated receptors γ (PPARγ) which is related to lipid synthesis. In addition, RBPs could attenuate obesity and hyperlipidemia by regulating disordered gut microbiota composition, such as increasing the abundance of microflora related to the synthesis of short chain fatty acids (SCFAs) (Bacteroidetes, Prevotellaceas_UCG_001, norank_f_Muribaculaceae, and Odoribacter) and controlling those related to intestinal inflammation (reduced abundance of Deferribacteres and increased abundance of Alistipes and ASF356) to exert anti-obesity and lipid-lowering activities. Our findings laid the foundation for the development and utilization of RBPs as a functional food to ameliorate obesity and hyperlipidemia.

show abstract

Section: Discussionmentioning

confidence: 99%

The Ameliorative Effect and Mechanisms of Ruditapes philippinarum Bioactive Peptides on Obesity and Hyperlipidemia Induced by a High-Fat Diet in Mice

Song

Cai

Wang³

et al. 2022

Nutrients

View full text Add to dashboard Cite

show abstract

“…The investigators transplanted IBATi-treated mouse fecal microbiomes into AIMD mice and revealed that restoration of a-diversity and Firmicutes:Bacteroidetes was involved in the amelioration of disease-related metabolic dysregulation in MAFLD mice [ 324 ]. In recent times, such combinatorial microbiome-related and animal model approaches have been adopted for a multitude of interventional factors ranging from small-molecule drugs [ 325 ] and defined dietary supplements or compounds [ 326 , 327 , 328 , 329 ] to herbal extracts [ 330 , 331 , 332 ].…”

Section: Mafld Preclinical Modelsmentioning

confidence: 99%

Utility of Human Relevant Preclinical Animal Models in Navigating NAFLD to MAFLD Paradigm

Chua

Low

Cheam

et al. 2022

IJMS

View full text Add to dashboard Cite

Fatty liver disease is an emerging contributor to disease burden worldwide. The past decades of work established the heterogeneous nature of non-alcoholic fatty liver disease (NAFLD) etiology and systemic contributions to the pathogenesis of the disease. This called for the proposal of a redefinition in 2020 to that of metabolic dysfunction-associated fatty liver disease (MAFLD) to better reflect the current understanding of the disease. To date, several clinical cohort studies comparing NAFLD and MAFLD hint at the relevancy of the new nomenclature in enriching for patients with more severe hepatic injury and extrahepatic comorbidities. However, the underlying systemic pathogenesis is still not fully understood. Preclinical animal models have been imperative in elucidating key biological mechanisms in various contexts, including intrahepatic disease progression, interorgan crosstalk and systemic dysregulation. Furthermore, they are integral in developing novel therapeutics against MAFLD. However, substantial contextual variabilities exist across different models due to the lack of standardization in several aspects. As such, it is crucial to understand the strengths and weaknesses of existing models to better align them to the human condition. In this review, we consolidate the implications arising from the change in nomenclature and summarize MAFLD pathogenesis. Subsequently, we provide an updated evaluation of existing MAFLD preclinical models in alignment with the new definitions and perspectives to improve their translational relevance.

show abstract

“…RNA‐seq technology has been widely used to study the mechanisms of action of various active components of disease resistance. Hou et al ( 2021 ) found that mungbean can alleviate liver steatosis in obese mice fed a high‐fat diet and observed enrichment of the NOD‐like receptor signaling pathway and Toll‐like receptor signaling pathway in KEGG pathway analysis; these data laid foundation for explaining the mechanism by which mungbean alleviates liver steatosis in obese mice. Zhu et al ( 2019 ) and others used RNA‐seq technology to sequence the liver transcriptome of rats with diet‐induced obesity treated with patchouli and found that the lipid‐lowering effect of patchouli on rats with diet‐induced obesity may be mediated by regulating the expression of Fasn‐, Socs2‐, and Ppp1r3b‐related genes and proteins in the insulin signaling pathway.…”

Section: Introductionmentioning

confidence: 98%

Effects of liposoluble components of highland barley spent grains on physiological indexes, intestinal microorganisms, and the liver transcriptome in mice fed a high‐fat diet

Zhang

Luo

Feng

et al. 2023

Food Science & Nutrition

View full text Add to dashboard Cite

The purpose of this study was to investigate the effects of the active ingredients of barley lees on the physiological indexes, intestinal flora, and liver transcriptome of mice fed a high‐fat diet. Twenty‐four male C57BL/6J mice were randomly divided into 4 groups and fed the experimental diets for 5 weeks. The results showed that the fat‐soluble components of distillers' grains significantly reduced body weight, abdominal fat, perirenal fat, blood glucose, low‐density lipoprotein cholesterol, triglycerides, and total cholesterol in the high‐fat diet‐fed mice (p < .05), significantly decreased alanine aminotransferase and malondialdehyde levels, and significantly increased total superoxide dismutase, catalase, reduced glutathione and glutathione peroxidase levels (p < .05). At the phylum level, lipid‐soluble components significantly increased the abundance of Bacteroidetes and decreased the Firmicutes/Bacteroidetes ratio. At the genus level, the relative abundances of Bacteroidetes and Clostridium were increased. Transcriptomic analysis showed that lipid‐soluble components of spent grains reduced the mRNA expression of ANGPTL8, CD36, PLTP, and SOAT1 and increased the mRNA expression of CYP7A1 and ABCA1 in the cholesterol metabolism pathway, promoted the transport of cholesterol, and inhibited the absorption of cholesterol, which can decrease cholesterol levels by speeding up the conversion of cholesterol into bile acids.

show abstract

Alteration of fecal microbiome and metabolome by mung bean coat improves diet-induced non-alcoholic fatty liver disease in mice

Cited by 28 publications

References 67 publications

The Ameliorative Effect and Mechanisms of Ruditapes philippinarum Bioactive Peptides on Obesity and Hyperlipidemia Induced by a High-Fat Diet in Mice

The Ameliorative Effect and Mechanisms of Ruditapes philippinarum Bioactive Peptides on Obesity and Hyperlipidemia Induced by a High-Fat Diet in Mice

Utility of Human Relevant Preclinical Animal Models in Navigating NAFLD to MAFLD Paradigm

Effects of liposoluble components of highland barley spent grains on physiological indexes, intestinal microorganisms, and the liver transcriptome in mice fed a high‐fat diet

Contact Info

Product

Resources

About