Alteration of functional connectivity in tinnitus brain revealed by resting-state fMRI?: A pilot study

Abstract

Our pilot study suggested that resting state functional magnetic resonance imaging (fMRI) could be useful to investigate possible alterations in resting-state neuronal activity between the auditory and non-auditory networks in tinnitus patients.

White matter integrity associated with clinical symptoms in tinnitus patients: A tract-based spatial statistics study

“…Many prior blood-oxygenation level-dependent (BOLD) functional MRI (fMRI) researches have provided evidence of altered interactions between multiple auditory and limbicrelated brain structures in tinnitus [2][3][4][5]. Contrary to those using BOLD fMRI, only a few studies have examined structural changes in the brain in tinnitus [6][7][8][9][10][11][12][13].…”

Modulation of Perception or Emotion? A Scoping Review of Tinnitus Neuromodulation Using Transcranial Direct Current Stimulation

“…14,15 The majority of research is consistent with increased connection between auditory cortex, attention, memory, and limbic systems in tinnitus patients using functional magnetic resonance imaging (fMRI). [16][17][18][19] Neuromodulation techniques can be divided into 2 categories: noninvasive (neurofeedback, transcranial magnetic stimulation [TMS], transcutaneous electrical nerve stimulation [TENS], transcutaneous vagus nerve stimulation [TVNS], and transcranial direct current stimulation [tDCS]) and invasive neuromodulation involving epidural stimulation or electrode implants to stimulate the auditory cortex, dorsolateral prefrontal cortex (DLPFC), subcutaneous occipital nerve stimulation, and deep brain stimulation). The scope of this review is limited to investigating the impact of tDCS on the perception and emotions associated with tinnitus.…”

Physiology, Psychoacoustics and Cognition in Normal and Impaired Hearing

“…Results indicate differences in connectivity between healthy and affected subject groups. One result showed reduced connectivity between the left and right auditory cortex, indicative of disturbed excitation and inhibition across hemispheres (Kim et al 2012). A different study found that in individuals with tinnitus connectivity was increased in numerous brain regions, including the cerebellum, parahippocampal gyrus, and sensorimotor areas.…”

“…Recently, resting-state fMRI has been used to investigate functional connectivity differences in individuals with tinnitus (Burton et al 2012;Davies et al 2014;Kim et al 2012;Maudoux et al 2012a, b). Results indicate differences in connectivity between healthy and affected subject groups.…”