Alteration of glutamate/GABA balance during acute alcohol intoxication in rats: Effect of Xingnaojing injection

Wei, Jingjing; Yao, Limei; Yang, Lei; Zhao, Wei; Shi, Si; Cai, Qingyan; Chen, Dingsheng; Li, Weirong; Wang, Qi

doi:10.1016/j.jep.2015.03.038

Cited by 17 publications

(9 citation statements)

References 30 publications

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“…Changes in cardiovascular responses such as hypotension and tachycardia are some of the clinical symptoms related to acute alcohol intoxication (Marco and Kelen, ). Considering the critical role of NO in the RVLM engaged in controlling BP and the sensitivity of glutamate and GABA‐mediated transmission to the action of EtOH (Chan et al., ; Wei et al., ), we tested the hypothesis that EtOH‐induced changes in glutamate, NO, and GABA pathways in the RVLM may contribute to EtOH‐induced cardiovascular responses. The major findings are as follows: (i) Acute administration of EtOH caused a dose‐dependent decrease in BP and a late increase in HR in conscious rats.…”

Section: Discussionmentioning

confidence: 99%

Involvement of NMDA Receptors, Nitric Oxide, and GABA in Rostral Ventrolateral Medulla in Acute Ethanol‐Induced Cardiovascular Responses in Rats

Lin

Chen

et al. 2018

Alcoholism Clin & Exp Res

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Section: Discussionmentioning

confidence: 99%

Involvement of NMDA Receptors, Nitric Oxide, and GABA in Rostral Ventrolateral Medulla in Acute Ethanol‐Induced Cardiovascular Responses in Rats

Lin

Chen

et al. 2018

Alcoholism Clin & Exp Res

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“…Alterations of this signaling have been associated with depression, learning disability and many neurodevelopmental disorders, including autism [4]. A balance between excitatory and inhibitory neurotransmission is critically important, and the loss of this balance is related to autism [5].…”

Section: Introductionmentioning

confidence: 99%

Glutamate excitotoxicity induced by orally administered propionic acid, a short chain fatty acid can be ameliorated by bee pollen

et al. 2017

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BackgroundRodent models may guide investigations towards identifying either environmental neuro-toxicants or drugs with neuro-therapeutic effects. This work aims to study the therapeutic effects of bee pollen on brain glutamate excitotoxicity and the impaired glutamine-glutamate- gamma amino butyric acid (GABA) circuit induced by propionic acid (PPA), a short chain fatty acid, in rat pups.MethodsTwenty-four young male Western Albino rats 3–4 weeks of age, and 45–60 g body weight were enrolled in the present study. They were grouped into four equal groups: Group 1, the control received phosphate buffered saline at the same time of PPA adminstration; Group 2, received 750 mg/kg body weight divided into 3 equal daily doses and served as acute neurotoxic dose of PPA; Group 3, received 750 mg/kg body weight divided in 10 equal doses of 75 mg/kg body weight/day, and served as the sub-acute group; and Group 4, the therapeutic group, was treated with bee pollen (50 mg/kg body weight) for 30 days after acute PPA intoxication. GABA, glutamate and glutamine were measured in the brain homogenates of the four groups.ResultsThe results showed that PPA caused multiple signs of excitotoxicity, as measured by the elevation of glutamate and the glutamate/glutamine ratio and the decrease of GABA, glutamine and the GABA/glutamate ratio. Bee pollen was effective in counteracting the neurotoxic effects of PPA to a certain extent.ConclusionIn conclusion, bee pollen demonstrates ameliorating effects on glutamate excitotoxicity and the impaired glutamine-glutamate-GABA circuit as two etiological mechanisms in PPA-induced neurotoxicity.

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“…Xingnaojing Injection is a traditional Chinese medicine prepared from Moschus , Fructus Gardeniae (FG), Radix Curcumae (RC), and borneol and is clinically used for treating stroke , cerebral ischemia , consciousness disturbance , and alcohol intoxication , with annual sales of more than two billion Chinese yuan. However, some adverse effects of Xingnaojing Injection have also been reported , which necessitates more strict QC of this injection.…”

Section: Introductionmentioning

confidence: 99%

Single standard substance for the determination of nine volatile components in the distillate of Fructus Gardeniae and Radix Curcumae (an intermediate of Xingnaojing Injection)

Fang

Yang

et al. 2017

J of Separation Science

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Xingnaojing Injection is a traditional Chinese medicine extensively used for stroke and cerebral ischemia. For better in-process quality control of Xingnaojing Injection, a method for the analysis of its intermediate (i.e., the distillate of Fructus Gardeniae and Radix Curcumae) is needed to monitor and optimize the hydrodistillation extraction process. In this work, nine major volatile components in the intermediate were identified: isophorone, 4-methylene-isophorone, curcumenone, curcumenol, curdione, curzerenone, furanodienone, curcumol, and germacrone. A quantitative analysis of multi-component with a single-marker method based on high-performance liquid chromatography with diode array detection was developed for the simultaneous determination of the nine components. In this method, only curdione was needed as the reference substance, and the other eight components were determined using their relative correction factors to curdione. In the method validation, good linearity (r > 0.9999), sensitivity, repeatability, and accuracy (recoveries within 95.3-105.4%) were shown. The repeatability and robustness of the relative correction factors were studied with different column temperatures, flow rates, detection wavelengths, columns, and instruments. In sample analyses, consistent results between the proposed method and the external standard method were shown. The proposed method provides a comprehensive and low-cost tool for the quality assessment of the intermediate of Xingnaojing Injection.

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Alteration of glutamate/GABA balance during acute alcohol intoxication in rats: Effect of Xingnaojing injection

Cited by 17 publications

References 30 publications

Involvement of NMDA Receptors, Nitric Oxide, and GABA in Rostral Ventrolateral Medulla in Acute Ethanol‐Induced Cardiovascular Responses in Rats

Involvement of NMDA Receptors, Nitric Oxide, and GABA in Rostral Ventrolateral Medulla in Acute Ethanol‐Induced Cardiovascular Responses in Rats

Glutamate excitotoxicity induced by orally administered propionic acid, a short chain fatty acid can be ameliorated by bee pollen

Single standard substance for the determination of nine volatile components in the distillate of Fructus Gardeniae and Radix Curcumae (an intermediate of Xingnaojing Injection)

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