1996
DOI: 10.1111/j.1540-8167.1996.tb00498.x
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Alteration of Human Placental Vascular Tone by Antiarrhythmic Medications In Vitro

Abstract: Based on these results, the medications tested should have no decremental effect on placental blood flow, with the possible exception of adenosine, which causes significant, dose-dependent contraction of human placental vessels in vitro. Should similar contraction be present in vivo, it may have an adverse effect on the fetus when administering adenosine to pregnant women at term or during labor.

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Cited by 13 publications
(3 citation statements)
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“…On the contrary, oral administration of labetalol is unable to cause any vasoactive effect on the fetoplacental vasculature, as fetal plasma levels of labetalol do not reach 10 −6 mol/l [ 150 , 151 ]. The nonselective β-AR antagonist, propranolol, has been shown to elicit a slight vasorelaxant effect (∼ 16%) on human placental artery and vein [ 153 ]. The low magnitude of the change in vascular tone has been associated with the lack of innervation in the fetoplacental vascular bed [ 153 ].…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…On the contrary, oral administration of labetalol is unable to cause any vasoactive effect on the fetoplacental vasculature, as fetal plasma levels of labetalol do not reach 10 −6 mol/l [ 150 , 151 ]. The nonselective β-AR antagonist, propranolol, has been shown to elicit a slight vasorelaxant effect (∼ 16%) on human placental artery and vein [ 153 ]. The low magnitude of the change in vascular tone has been associated with the lack of innervation in the fetoplacental vascular bed [ 153 ].…”
Section: Methodsmentioning
confidence: 99%
“…The nonselective β-AR antagonist, propranolol, has been shown to elicit a slight vasorelaxant effect (∼ 16%) on human placental artery and vein [ 153 ]. The low magnitude of the change in vascular tone has been associated with the lack of innervation in the fetoplacental vascular bed [ 153 ]. We speculate that the blockade action of propranolol on β-ARs may not promote any change in the fetoplacental vascular tone, based on evidence of dosage.…”
Section: Methodsmentioning
confidence: 99%
“…Management of cocaine‐induced arrhythmias in pregnant women is usually similar to that in nonpregnant women but special consideration must be given to avoid adverse fetal effects (57). Omar et al evaluated the tone response caused by antiarrhythmic medications in human placental vessels from normal term pregnancies and concluded that adenosine causes significant dose‐dependent contraction of human placental vessels in vitro (74). Should similar contractions be present in vivo , they may have an adverse effect on the fetus when administering adenosine to pregnant patients with cocaine‐induced arrhythmias.…”
Section: Fetal Implications Of Peripartum Drug Therapymentioning
confidence: 99%