2015
DOI: 10.1097/bcr.0000000000000211
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Alteration of Leukocyte Count Correlates With Increased Pulmonary Vascular Permeability and Decreased PaO2

Abstract: Leucocytes are activated systemically and their numbers increase soon after a burn followed by a rapid decline to low normal or subnormal levels, possibly by increased extravasation. Experimental data supports that an important target for such extravasation is the lungs and that leucocytes when they adhere to endothelial cells cause an increase in vascular permeability. We investigated a possible relation between early increased pulmonary vascular permeability or a decreased PaO2:FiO2-ratio and the dynamic cha… Show more

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Cited by 8 publications
(3 citation statements)
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References 33 publications
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“…The study was conducted at a national burn center (Linköping University Hospital Burn Centre) in a cohort of patients that has previously been reported[19]. Twenty patients with burns involving 20% or more of the total body surface area were included.…”
Section: Methodsmentioning
confidence: 99%
“…The study was conducted at a national burn center (Linköping University Hospital Burn Centre) in a cohort of patients that has previously been reported[19]. Twenty patients with burns involving 20% or more of the total body surface area were included.…”
Section: Methodsmentioning
confidence: 99%
“…Admission Neutrophil to Lymphocyte ratio has been found to be predictive for mortality estimates 14 . This may be anticipated to be so particularly as it has been shown that very high leucocyte counts can be registered early after burns and they correlate to the size of the burn, when there is a flood of leucocytes from the bone marrow into the central circulation 37 . Also, this estimate may then be claimed as an outcome measure of the burn trauma and can be hypothesised to predict mortality.…”
Section: Discussionmentioning
confidence: 99%
“…Rehberg et al [43] put together a useful compendium of their research with the ovine model and pulmonary pathophysiology in burn trauma. Two centers have described the phenomenon of leukocyte activation contributing to pulmonary vascular permeability and pulmonary edema in conjunction with inflammatory agents such as thrombin which promotes systemic capillary leakage and systemic interstitial edema [44,45] .…”
Section: Human and Ovine Studies Of At Concentrates For Pulmonary Injmentioning
confidence: 99%