Alteration of local adipose tissue trace element homeostasis as a possible mechanism of obesity-related insulin resistance

Tinkov, Alexey A.; Синицкий, А. И.; Popova, Elizaveta V.; Немерешина, О. Н.; Gatiatulina, Eugenia R.; Skalnaya, Margarita G.; Skalny, Anatoly V.; Nikonorov, Alexandr А.

doi:10.1016/j.mehy.2015.06.005

Cited by 33 publications

(17 citation statements)

References 78 publications

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“…Decreased adipose tissue Cr and V content are in agreement with our previous observation also indicating a significant association between high-fat induced decrease in adipose tissue Cr and V content and metabolic parameters in rats with excessive adiposity [21]. Taking into account the role of chromium [42] and vanadium [43] in insulin signaling, we have also supposed that a decrease in Cr and V levels in adipocytes may at least partially mediate obesity-related insulin resistance [44].…”

Section: Discussionsupporting

confidence: 92%

“…Current findings support our earlier hypothesis that altered adipose tissue trace element levels may be used as early markers of obesity-associated metabolic risk [44]. To our knowledge, this is the first report of early high-fat diet-induced alteration of trace element content in tissues in an animal model of excessive adiposity without metabolic disturbances.…”

Section: Discussionsupporting

confidence: 90%

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Early High-Fat Feeding Induces Alteration of Trace Element Content in Tissues of Juvenile Male Wistar Rats

Tinkov

Gatiatulina

Popova

et al. 2016

Biol Trace Elem Res

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The primary objective of the current study was to assess the influence of early high-fat feeding on tissue trace element content in young male Wistar rats. Twenty weanling male Wistar rats were divided into two groups fed standard (STD) or high-fat diet (HFD) containing 10 and 31.6 % of total calories from fat, respectively, for 1 month. Serum lipid spectrum, apolipoproteins, glucose, insulin, adiponectin, and leptin levels were assessed. The level of trace elements was estimated using inductively coupled plasma mass spectrometry. High-fat feeding significantly increased epidydimal (EDAT) and retroperitoneal adipose tissue (RPAT), as well as total adipose tissue mass by 34, 103, and 59 %, respectively. Serum leptin levels in HFD animals were twofold higher than those in the control rats. No significant difference in serum lipid spectrum, apolipoproteins, glucose, adiponectin, and insulin was detected between the groups. HFD significantly altered tissue trace element content. In particular, HFD-fed animals were characterized by significantly lower levels of Cu, I, Mn, Se, and Zn in the liver; Cr, V, Co, Cu, Fe, and I content of EDAT; Co, Cu, I, Cr, V, Fe, and Zn concentration in RPAT samples. At the same time, only serum Cu was significantly depressed in HFD-fed animals as compared to the control ones. Hair Co, Mn, Si, and V levels were significantly increased in comparison to the control values, whereas Se and I content was decreased. HFD feeding induced excessive adiposity and altered tissue trace element content in rats without insulin resistance, adiponectin deficiency, and proatherogenic state. Hypothetically, trace element disbalance may precede obesity-associated metabolic disturbances.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 90%

Early High-Fat Feeding Induces Alteration of Trace Element Content in Tissues of Juvenile Male Wistar Rats

Tinkov

Gatiatulina

Popova

et al. 2016

Biol Trace Elem Res

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“…Adipocyte endocrine dysfunction and adipose tissue infl ammation triggers obesity development (Maury and Brichard, 2010). At the same time, it has been supposed that altered adipose tissue trace element profi le may aggravate metabolic disruption in obesity (Tinkov et al, 2015a). In particular, we have shown that dietary obesity is associated with impaired adipose tissue chromium and vanadium content in laboratory rodents.…”

Section: Introductionmentioning

confidence: 73%

Decreased adipose tissue zinc content is associated with metabolic parameters in high fat fed Wistar rats

Tinkov

Popova

Gatiatulina

et al. 2016

Acta Sci Pol Technol Aliment

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Background. Limited data on adipose tissue zinc content in obesity exist. At the same time, the association between adipose tissue zinc content and metabolic parameters in dietary-induced obesity is poorly studied. Therefore, the primary objective of this study is to assess adipose tissue zinc content and its association with morphometric parameters, adipokine spectrum, proinfl ammatory cytokines, and apolipoprotein profi le in high fat fed Wistar rats. Material and methods. A total of 48 adult female Wistar rats were used in the present study. Rats were fed either control (10% of fat) or high fat diet (31.6% of fat). Adipose tissue zinc content was assessed using inductively coupled plasma mass spectrometry. Rats' serum was examined for adiponectin, leptin, insulin, interleukin-6, and tumor necrosis factor-α using enzyme-linked immunosorbent assay kits. Serum glucose and apolipoprotein spectrum were also evaluated. Results. High fat feeding resulted in a signifi cant 34% decrease in adipose tissue zinc content in comparison to the control values. Fat pad zinc levels were signifi cantly inversely associated with morphometric parameters, circulating leptin, insulin, tumor necrosis factor-α levels and HOMA-IR values. At the same time, a signifi cant correlation with apolipoprotein A1 concentration was observed. Conclusion. Generally, the obtained data indicate that (1) high fat feeding results in decreased adipose tissue zinc content; (2) adipose tissue zinc content is tightly associated with excessive adiposity, infl ammation, insulin resistance and potentially atherogenic changes.

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“…At the cellular level, there are two main mechanisms responsible of IR development: (1) cellular stress in the endoplasmic reticulum, and in the mitochondria of adipocytes, hepatocytes and myocytes; and (2) release of pro-inflammatory cytokines, principally, TNF-α and IL-6 by activation of the Toll-like receptor 4 (TLR-4) on the surface of infiltrated macrophages of white adipose tissue and liver [72,73]. Obtained data point towards multiple triggering paths for this processes to be started, however, it is the obesity-associated chronic low-grade inflammation the most linked one [72,73].…”

Section: Insulin Resistance Aetiologymentioning

confidence: 99%

Immunometabolism in Obesity

Chavarria-Ávila¹,

Navarro-Hernández²,

Guzmán-Ornelas³

et al. 2017

Adiposity - Omics and Molecular Understanding

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Immunometabolism is a current issue that has shown relevance in recent years, because the way we understand the adipose tissue has shifted from simply being a site of energy storage to a very active endocrine organ, which dysregulation has a major impact on other systems, especially on the immune one. Understanding the molecular basis of the regulation of adipose tissue is essential to look for alternatives in the treatment and prognosis of obesity in future generations. In this regard, it is described that the immune system has great importance in physiological processes of adipose tissue and vice versa. The main objective of this chapter is to describe the relationship between the immune system and metabolism, emphasizing dysregulation when obesity is present. Upon completion of this chapter, the reader will be able to understand the relationship between the immune system and metabolism, in normal and obesity states; also, will identify the chronic state of low-grade inflammation as the main etiological factor of obesity co-morbidities, such as insulin resistance, diabetes mellitus, osteoarthritis and susceptibility to some kinds of cancer, among others.

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Alteration of local adipose tissue trace element homeostasis as a possible mechanism of obesity-related insulin resistance

Cited by 33 publications

References 78 publications

Early High-Fat Feeding Induces Alteration of Trace Element Content in Tissues of Juvenile Male Wistar Rats

Early High-Fat Feeding Induces Alteration of Trace Element Content in Tissues of Juvenile Male Wistar Rats

Decreased adipose tissue zinc content is associated with metabolic parameters in high fat fed Wistar rats

Immunometabolism in Obesity

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