alteration of Mean Platelet Volume in the Pathogenesis of Acute Ischemic Stroke: Cause or Consequence?

Ayas, Zeynep Özözen; Can, Ufuk

doi:10.18071/isz.71.0049

Cited by 6 publications

(7 citation statements)

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“…We corresponded with authors for five studies, but data were not available. Therefore, 34 articles were included in the meta-analysis [10][11][12][13][14][15]. Three studies were carried out in the United States, 12 in Europe, ten in Asia, one in Africa, and eight studies were intercontinental.…”

Section: Resultsmentioning

confidence: 99%

“…Three studies showed that patients with AS had higher PC than controls [24,35,36]. Eleven studies demonstrated lower PC in the patient group [12][13][14]23,[25][26][27]30,32,35,43], and 11 studies found no difference in PC between patients and controls (Table I, Supplementary Table VI) [11,15,28,29,33,37,41,42,44,46,47]. One study did not provide PC results.…”

Section: Pcmentioning

confidence: 99%

“…Seventeen results of the 27 studies revealed that patients with stroke had higher MPV than controls [10,12,25,27,28,34,35,39,41-43, [46][47][48]50]. Ten studies found no difference in MPV between patients and controls [14,15,28,29,35,36,38,45,49], and two studies demonstrated a higher MPV in the control group (Table I, Supplementary Table VI) [13,40]. The mean MPV for all publications was 9.8 fL (95% CI 9.4-10.1) for patients and 9.2 fL (95% CI, 8.8-9.6) for controls.…”

Section: Mpvmentioning

confidence: 99%

“…Some groups reported that patients with AS had significantly increased MPV or PC compared with controls [10,11], whereas other studies found decreased MPV or PC values in AS patients [12,13]. Additionally, some studies have observed no association between these parameters and AS [14,15]. Taking these inconsistent findings into consideration, we undertook a meta-analysis to investigate the association between MPV, PC, and AS.…”

Section: Introductionmentioning

confidence: 99%

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Platelet count and mean volume in acute stroke: a systematic review and meta-analysis

Sadeghi

Sándor

Zsóri³

et al. 2019

Platelets

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Changes of mean platelet volume (MPV) and platelet count (PC) could be a marker or a predictor of acute stroke (AS). We conducted a systematic review and meta-analysis of the published literature on the reporting of MPV and PC in AS. Studies were included in accordance with Patient Population or Problem, Intervention, Comparison, Outcomes, and Setting framework. The PRISMA strategy was used to report findings. Risk of bias was assessed with the Newcastle-Ottawa Scale. We included 34 eligible articles retrieved from the literature. PC was significantly lower in AS patients [standardized mean difference (SMD) = − 0.30, (95% CI: − 0.49 to − 0.11), N = 2492, P = .002] compared with controls (N = 3615). The MPV was significantly higher [SMD = 0.52 (95% CI: 0.28-0.76), N = 2739, P < .001] compared with controls (N = 3810). Subgroup analyses showed significantly lower PC in both ischemic stroke (Difference SMD = −0.18, 95% CI: −0.35-0.01) and hemorrhagic stroke (−0.94, −1.62 to −0.25), but only samples by citrate anticoagulant showed significantly lower result for patients compared to controls (−0.36, −0.68 to −0.04). Ischemic stroke patients had higher MPV (0.57, 0.31-0.83), and samples by Ethylenediaminetetraacetic acid (EDTA) anticoagulant showed significantly higher result for patients compared to controls (0.86, 0.55--1.17). PC and MPV appeared to be significantly different between patients with AS and control populations. MPV was significantly higher in ischemic stroke and PC was significantly lower in both ischemic and hemorrhagic strokes. These characteristics might be related to AS and associated with it. It is advisable to pay attention to elapsed time between phlebotomy and hematology analysis, anticoagulant and hemocytometer types in AS. Systematic review registration: This meta-analysis is registered on the International Prospective Register of Systematic Reviews (PROSPERO) under registration number CRD42017067864 (https:// www.crd.york.ac.uk/prospero/display_record.php?RecordID=67864).

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Section: Resultsmentioning

confidence: 99%

Section: Pcmentioning

confidence: 99%

Section: Mpvmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Platelet count and mean volume in acute stroke: a systematic review and meta-analysis

Sadeghi

Sándor

Zsóri³

et al. 2019

Platelets

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“…Ischemic stroke develops as a result of atherothrombotic, embolic or hemodynamic processes. The atherothrombotic process, which includes fibrin production, platelet activation and disruption of fibrinolysis, plays an important role in the development of ischemic stroke (4).…”

Section: Introductionmentioning

confidence: 99%

Mean Platelet Volume Values and Its Effects on Prognosis in Patients with Acute Ischemic Stroke

Demir¹

2019

BMB

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Stroke is a rapid onset of focal or global loss of cerebral function and is the most common cause of mortality and morbidity in adulthood cancer and heart disease patients. Although it has been reported that mean platelet volume (MPV) values may be an independent risk factor for the severity and prognosis of stroke, the results of previous studies are inconsistent. The aim of the present study was to determine the MPV values of ischemic stroke patients which reflects the activity and function of platelets and to observe its effect on clinical outcomes. Method: Sixty-two acute ischemic stroke patients were recruited for the study. Clinical information, MPV, platelet, white blood cell (WBC) and neutrophil, CRP and troponin-T levels were obtained. Results: The mean ± standard deviation age was 72.4±12.6 years. At the end of the study, 28 patients were discharged and 34 patients passed away. The frequency of bilateral stroke was higher in deceased patients (p=0.005). In addition, platelet counts were significantly higher in discharged patients (p=0.016). At first admission, MPV values were 10.59±1.01 fL in discharged patients and 11.29±1.12 fL in deceased patients (p=0.029). At the end of the study, MPV values were measured as 11.46±1.28 fL in deceased patient sand 10.47±0.74 fL in discharged patients (p<0.001). WBC and neutrophil counts, troponin-T and CRP values were not significantly different between deceased and discharged patients (p>0.05). Conclusion: Our study indicated that MPV and platelet levels may be associated with mortality in acute ischemic stroke patients and can be used as prognostic markers.

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The relationship between mean platelet volume and metabolic syndrome in patients with type 2 diabetes mellitus

Ding¹,

Wang

X³

et al. 2021

Medicine

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This study aimed to investigate the association between mean platelet volume (MPV) and metabolic syndrome (MetS) in patients with type 2 diabetes mellitus (T2DM). Data for 1240 patients with T2DM admitted to the Department of Endocrinology at the First Affiliated Hospital of Guangxi Medical University between January 1, 2017 and June 1, 2020 were collected retrospectively via electronic medical records, including demographic information, complete blood count, lipid profile, and glucose metabolism indexes. MetS was defined according to the Chinese Diabetes Society. Among the 1240 patients enrolled, 873 (70.40%) had MetS. MPV was significantly higher in patients with MetS ( P < .001). For individual MetS components, MPV was significantly higher in the presence of abdominal obesity ( P = .013) and hypertriglyceridemia ( P = .026), but did not differ in the presence of elevated blood pressure ( P = .330) or low high-density lipoprotein cholesterol ( P = .790). Moreover, MPV was independently associated with MetS after adjustment for sex, smoking, alcohol drinking, white blood cell count, fasting C-peptide, and body mass index (odds ratio 1.174, 95% confidence interval 1.059–1.302). The odds ratio for MetS in the highest tertile, compared with the lowest MPV tertile, was 1.724 (95% confidence interval 1.199–2.479, P for trend = .003) after multiple adjustment. In stratified analyses, the positive correlation of MPV with MetS was significant only in patients who were older, male, or overweight, or who had poor glycemic control. In conclusion, high MPV was positively associated with the presence of MetS in patients with T2DM, particularly older, male, or overweight patients, or those with poor glycemic control.

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alteration of Mean Platelet Volume in the Pathogenesis of Acute Ischemic Stroke: Cause or Consequence?

Abstract: Although there was no alteration of platelet counts, MPV values were increased 7 days after stroke in patients with acute ischemic stroke.

Cited by 6 publications

References 0 publications

Platelet count and mean volume in acute stroke: a systematic review and meta-analysis

Platelet count and mean volume in acute stroke: a systematic review and meta-analysis

Mean Platelet Volume Values and Its Effects on Prognosis in Patients with Acute Ischemic Stroke

The relationship between mean platelet volume and metabolic syndrome in patients with type 2 diabetes mellitus

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