Alteration of myocardial characteristics and function in patients with obstructive sleep apnea

Kawanishi, Yasunori; Ito, Takahide; Okuda, Naoki; Emura, Narutsugu; Hayashi, Toshio; Futai, Rie; Yanagawa, Hiroshi; Kitaura, Yasushi

doi:10.1016/j.ijcard.2007.08.132

Cited by 12 publications

(7 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this regard, Kawanishi and colleagues demonstrated that Em wave amplitude at the TDI analysis directly and positively correlated with the severity of OSAS in adults [35][36][37][38]. Our data did not reveal a significant difference in the early phase of the LV diastole at either the conventional or TDI analyses, but we did observe a negative correlation between oxygen overnight saturation and the Em/Am ratio in OSAS patients compared with that in the control group.…”

Section: Discussioncontrasting

confidence: 59%

Early cardiac abnormalities and increased C-reactive protein levels in a cohort of children with sleep disordered breathing

et al. 2011

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 59%

Early cardiac abnormalities and increased C-reactive protein levels in a cohort of children with sleep disordered breathing

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Especially the relationship between the E/E' ratio and the increased left ventricle filling pressures have demonstrated that filling pressures have been increased with the severity of OSA and increased concomitant diastolic dysfunction. Besides, the relationship between the increased E/E' ratio and myocardial fibrosis indicated that myocardial dysfunction and myocardial fibrosis might be increased in OSA patients in relation to the OSA severity (30). The relationship between GL S value and E/E' indicated that increased left ventricle filling pressures and endocardial fibrosis might be the influential factors in development of the subclinical LV systolic dysfunction.…”

Section: Discussionmentioning

confidence: 95%

Evaluation of subclinical left ventricular systolic dysfunction in patients with obstructive sleep apnea by automated function imaging method; an observational study

Altekin¹,

Yanıkoğlu²,

Karakaş³

et al. 2012

Anadolu Kardiyol Derg

View full text Add to dashboard Cite

Objective: We aimed to evaluate the subclinical left ventricular (LV) systolic dysfunction with the automated function imaging method (AFI) based on speckle tracking echocardiography (STE) in obstructive sleep apnea patients (OSA) with normal left ventricular ejection fraction (LVEF) and without any confounding disease that can cause myocardial dysfunction. Methods: Twenty-one healthy individuals and 58 OSA patients were included in this observational cross-sectional study. According to the severity of disease, OSA patients were examined in three groups; mild, moderate and severe OSA. Apical 2-, 3-and 4-chamber images were obtained for AFI evaluation. The global systolic longitudinal strain (GL S ) values were determined for each view, and averages of these were used in comparison of the patient groups. One-way ANOVA, Kruskal-Wallis, Pearson correlation tests and linear regression analysis were used for statistical analysis. Results: The GL S values of the OSA patients were lower than of the healthy individuals and these values were decreased along with the OSA severity (Healthy:-25.58±-2.16%, Mild:-23.93±-3.96%, Moderate:-21.27±-2.60%, Severe:-16.94±-2.66%, respectively). The difference was significant between moderate OSA patients and healthy individuals, and significant between severe OSA patients and all other groups (p<0.03). The apnea-hypopnea index was found to be correlated with the GL S (β=-0.659, 95% CI: 0.09-0.17, p<0.001). Conclusion: Longitudinal LV mechanics in OSA patients with normal LVEF are deteriorated in the subclinical stage being associated with the severity of disease. AFI can be used as an effective and safe method in the determination of subclinical myocardial dysfunction in OSA patients, because it is semi-automated and easy to use with a short analysis time.(Anadolu Kardiyol Derg 2012; 12: 320-30) Key words: Obstructive sleep apnea, speckle tracking echocardiography, myocardial strain, regression analysis 320 ÖZET Amaç: Sol ventrikül ejeksiyon fraksiyonu normal ve miyokart fonksiyonlarını etkileyecek ek hastalığı bulunmayan, obstrüktif uyku apneli (OUA) hastalarda, subklinik sol ventrikül sistolik disfonksiyonunu, iki boyutlu benek izleme ekokardiyografi tekniğine dayanan, otomatik fonksiyonel görün-tüleme yöntemi (OFG) ile değerlendirmeyi amaçladık. Yöntemler: Gözlemsel enine-kesitli çalışmamıza 21'i sağlıklı, 58'i OUA hastası olan toplam 79 kişi alındı. OUA'lı hastalar hastalığın ciddiyetine göre hafif, orta ve ağır olarak 3 gruba ayrıldı. OFG değerlendirmesi için sol ventrikülün apikal 2-, 3-, 4-boşluk görüntüleri kullanıldı. İlgili boşluk-lara ait sistolik longitüdinal deformasyon değerlerinin aritmetik ortalaması olan, global longitüdinal deformasyon değerleri gruplar arasında karşılaştırıldı. İstatistiksel analiz için tek -yönlü ANOVA, Kruskal-Wallis, Pearson korelasyon testleri ve doğrusal regresyon analizi kullanıldı. Bulgular: Sağlıklı gruba göre hafif OUA grubundan itibaren hastalığın ciddiyeti ile global longitüdinal deformasyon değerleri azalmaktaydı (Sağlıklı: -%25...

show abstract

“…Other studies reported a significant correlation between E/A and mean nocturnal oxygen saturation [79] or between e and the AHI [82]. However, in numerous studies, LV diastolic dysfunction was observed in OSAS patients, together with older age [76], higher BP [46,81,87], higher BMI [81] or higher LVH [46,78,81,85]. In a recent review, Baguet et al [29] focused on common OSAS co-morbidities, such as AHT and diabetes, which lead to OSAS-related cardiac disorders, such as coronary artery disease, LVH and atrial fibrillation, thus establishing a strong basis for a perfect continuum from diastolic dysfunction and heart failure with preserved ejection fraction to systolic heart failure.…”

Section: Diastolic Dysfunction In Osasmentioning

confidence: 97%

“…Furthermore, several studies have shown various impaired LV diastolic function markers in patients with OSAS compared with in controls: enlarged left atrial size [46,[78][79][80], prolonged isovolumic relaxation time (IVRT) [46,57,78,81], altered E/A ratio [46,78,79,[81][82][83][84], lower early diastolic mitral annular velocity (e ) [79,82,83,85,86] and increased E/e ratio [43,78,87] (Fig. 3).…”

Section: Diastolic Dysfunction In Osasmentioning

confidence: 99%

Consequences of obstructive sleep apnoea syndrome on left ventricular geometry and diastolic function

Bodez

Damy

Soulat-Dufour³

et al. 2016

Archives of Cardiovascular Diseases

View full text Add to dashboard Cite

Obstructive sleep apnoea syndrome (OSAS) is a frequent sleep disorder that is known to be an independent risk factor for arterial hypertension (AHT). Potential confounding factors associated with both OSAS and AHT, such as age, diabetes mellitus and obesity, have been explored extensively, and are considered as independent but additive factors. However, these factors are also contributors to left ventricular (LV) hypertrophy (LVH) and LV diastolic dysfunction, both of which are important causes of cardiovascular morbidity, and have been reported to be associated with OSAS for decades. In this review, we present an overview of how OSAS may promote changes in LV geometry and diastolic dysfunction through its best-known cardiovascular complication, arterial hypertension. We also summarize the epidemiological links between OSAS and LVH, outline diastolic dysfunction in OSAS patients, and try to highlight the mechanisms responsible, focusing on the effect of confounding factors.

show abstract

Alteration of myocardial characteristics and function in patients with obstructive sleep apnea

Cited by 12 publications

References 16 publications

Early cardiac abnormalities and increased C-reactive protein levels in a cohort of children with sleep disordered breathing

Early cardiac abnormalities and increased C-reactive protein levels in a cohort of children with sleep disordered breathing

Evaluation of subclinical left ventricular systolic dysfunction in patients with obstructive sleep apnea by automated function imaging method; an observational study

Consequences of obstructive sleep apnoea syndrome on left ventricular geometry and diastolic function

Contact Info

Product

Resources

About