Alteration of ouabain toxicity by cardiac denervation

Boyajy, Louis D.; Nash, Clinton B.

doi:10.1016/0041-008x(66)90114-1

Cited by 33 publications

(18 citation statements)

References 11 publications

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“…The lethal dose of ouabain, however, was similar between the both groups as shown in Table 1. The lower maximal ectopic rate and the major incidence of ventricular standstill instead of ventricular fibrillation as the terminating event in the pithed donor dogs in the present study coincide with the previous results obtained after interruption of cardiac sympathetic nerve innervation (Morrow et al 1963;Erlij and Mendez 1964;Boyajy and Nash 1966;Hashimoto et al 1973;Roberts et al 1976). Thus, adrenergic influences on digitalis effects were suggested also in the present results.…”

Section: Discussionsupporting

confidence: 82%

Effects of ouabain on atrioventricular conduction: Simultaneous observation in the isolated AV node preparation and the in situ heart of the dog.

Hashimoto

Motomura

Iwamoto

et al. 1980

Tohoku J. Exp. Med.

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Section: Discussionsupporting

confidence: 82%

Effects of ouabain on atrioventricular conduction: Simultaneous observation in the isolated AV node preparation and the in situ heart of the dog.

Hashimoto

Motomura

Iwamoto

et al. 1980

Tohoku J. Exp. Med.

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“…The relationship between the adrenergic nervous system and digitalis-induced arrhythmias is well established (Boyajy & Nash, 1968;Cagin et al, 1976). Cardiac glycosides cause increased neurotransmitter overflow from autonomic nerve endings in a variety of tissues including heart (Stickney, 1980;Powis, 1983).…”

Section: Discussionmentioning

confidence: 99%

Effects of α‐adrenoceptor agonists and antagonists on ouabain‐induced arrhythmias and cardiac arrest in guinea‐pig

Thomas

Tripathi

1986

British J Pharmacology

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1 Effects of a-adrenoceptor agonists and antagonists with different affinity for ak-and ot2-receptors on ouabain-induced arrhythmias in guinea-pigs were studied. 2 Early arrhythmias, ventricular fibrillation and cardiac arrest were induced in anaesthetized guineapigs by the slow intravenous infusion of ouabain. 3 Phenylephrine and yohimbine potentiated the cardiotoxicity of ouabain significantly whereas prazosin and clonidine showed significant antiarrhythmic effects and delayed the cardiac arrest. 4 It is concluded that selective ax-receptor stimulation and a2-receptor blockade increases the cardiotoxic effects of ouabain and selective 2-receptor stimulation and a,-receptor blockade inhibits ouabain-induced arrhythmias and cardiac arrest in guinea-pigs.

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“…patterns. Boyajy & Nash (1966) have found that either spinal cord transection or spinal anaesthesia protect against arrhythmias induced by systemic administration of ouabain. In the present experiments systemic administration of daunomycin produced not only e.c.g.…”

Section: Discussionmentioning

confidence: 99%

Role of the sympathetic nervous system in daunomycin‐induced arrhythmia in the monkey

Burka¹,

Herman²,

Vick³

1970

British J Pharmacology

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Infusion of daunomycin 50 mg/kg in the monkey consistently induced ventricular arrhythmias which were not influenced by bilateral vagotomy. A central sympathetic component to the arrhythmias was suggested because spinal transection, ganglionic blockade or bilateral stellate ganglion‐ectomy prevented any alterations in the e.c.g. Bilateral adrenalectomy or splanchnic nerve section protected three of six animals. This source of catecholamines may not be necessary in every case to initiate the arrhythmia. Guanethidine was a relatively ineffective antiarrhythmic agent. Timing appears to be important with this agent. Pargyline, by monoamine oxidase inhibition or other mechanisms, significantly lowered the arrhythmic dose of daunomycin. Reserpine pre‐treatment, on the other hand, prevented any e.c.g. alterations following daunomycin. Phenoxybenzamine exerted significant protection which may be related to its cardiodepressant properties. Alterations in e.c.g. were seen in all (+)‐propranolol pretreated animals, although the arrhythmic period was modified in two of three experiments. Racemic (±)‐propranolol, which exerts direct myocardium depression as well as β‐adrenoceptor blockade, was completely protective in four of five experiments. The results of the present experiments indicate that the sympathetic nervous system is intimately involved in the daunomycin arrhythmia.

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Alteration of ouabain toxicity by cardiac denervation

Cited by 33 publications

References 11 publications

Effects of ouabain on atrioventricular conduction: Simultaneous observation in the isolated AV node preparation and the in situ heart of the dog.

Effects of ouabain on atrioventricular conduction: Simultaneous observation in the isolated AV node preparation and the in situ heart of the dog.

Effects of α‐adrenoceptor agonists and antagonists on ouabain‐induced arrhythmias and cardiac arrest in guinea‐pig

Role of the sympathetic nervous system in daunomycin‐induced arrhythmia in the monkey

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