Alteration of paraoxonase, arylesterase and lactonase activities in people around fluoride endemic area of Tamil Nadu, India

Arulkumar, Mani; Raji, Vijayan; Sakayanathan, Penislusshiyan; Sathishkumar, Palanivel; Angayarkanni, Jayaraman; Palvannan, Thayumanavan

doi:10.1016/j.cca.2017.05.036

Cited by 8 publications

(9 citation statements)

References 48 publications

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“…However, of fundamental importance, evidence from epidemiological studies confirm this association and provide a biological gradient by which serum F levels may inhibit Na+, K+-ATPase activity in humans. This effect has been found to occur at serum F levels < 5.0 µM in adults [221,222]. Furthermore, it is important to note that AGEs have also been shown to inhibit Na+, K+-ATPase enzyme activity [223].…”

Section: Molecular Mechanisms Underlying Fluoride Contribution To mentioning

confidence: 99%

“…Previous investigations have also demonstrated that F exposure significantly inhibits PON-1 activity in humans. The activity of Pon1 was found to decline significantly in a dose dependent manner with increasing serum F concentrations [221]. At 6.8 µM serum F levels the activity of PON1 was found to decline by approximately 30% compared to controls with a serum F level of 3.6 µM.…”

Section: Molecular Mechanisms Underlying Fluoride Contribution To mentioning

confidence: 99%

“…At 6.8 µM serum F levels the activity of PON1 was found to decline by approximately 30% compared to controls with a serum F level of 3.6 µM. At serum F levels of 14.75 µM Pon1 activity was found to decline by approximately 60% [221].…”

Section: Molecular Mechanisms Underlying Fluoride Contribution To mentioning

confidence: 99%

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The Contribution of Fluoride to the Pathogenesis of Eye Diseases: Molecular Mechanisms and Implications for Public Health

Waugh¹

2019

IJERPH

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This study provides diverse lines of evidence demonstrating that fluoride (F) exposure contributes to degenerative eye diseases by stimulating or inhibiting biological pathways associated with the pathogenesis of cataract, age-related macular degeneration and glaucoma. As elucidated in this study, F exerts this effect by inhibiting enolase, τ-crystallin, Hsp40, Na+, K+-ATPase, Nrf2, γ -GCS, HO-1 Bcl-2, FoxO1, SOD, PON-1 and glutathione activity, and upregulating NF-κB, IL-6, AGEs, HsP27 and Hsp70 expression. Moreover, F exposure leads to enhanced oxidative stress and impaired antioxidant activity. Based on the evidence presented in this study, it can be concluded that F exposure may be added to the list of identifiable risk factors associated with pathogenesis of degenerative eye diseases. The broader impact of these findings suggests that reducing F intake may lead to an overall reduction in the modifiable risk factors associated with degenerative eye diseases. Further studies are required to examine this association and determine differences in prevalence rates amongst fluoridated and non-fluoridated communities, taking into consideration other dietary sources of F such as tea. Finally, the findings of this study elucidate molecular pathways associated with F exposure that may suggest a possible association between F exposure and other inflammatory diseases. Further studies are also warranted to examine these associations.

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Section: Molecular Mechanisms Underlying Fluoride Contribution To mentioning

confidence: 99%

Section: Molecular Mechanisms Underlying Fluoride Contribution To mentioning

confidence: 99%

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The Contribution of Fluoride to the Pathogenesis of Eye Diseases: Molecular Mechanisms and Implications for Public Health

Waugh¹

2019

IJERPH

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“…It is well established that NKA activity is inhibited by fluoride [117,118,119,120,121,122,123,124,125,126,127,128,129,130,131,132,133,134,135,136,137,138]. Furthermore, the results from human studies provide a biological gradient by which serum fluoride levels inhibit NKA activity in adults [137,138]. Considering the exclusion criteria and number of participants in these latter studies, these findings are significant.…”

Section: Introductionmentioning

confidence: 99%

“…Notably, the inhibitory effect was found to occur in adults at serum fluoride levels < 5.0 µM and the inhibitory effects increased significantly as serum F levels increased in a dose dependent manner. [137,138]. For example, Arulkumar et al observed that at serum ionic fluoride levels of 14.75 µM the activity of NKA declined by approximately 60 per cent compared to controls [137].…”

Section: Introductionmentioning

confidence: 99%

Fluoride Exposure Induces Inhibition of Sodium-and Potassium-Activated Adenosine Triphosphatase (Na+, K+-ATPase) Enzyme Activity: Molecular Mechanisms and Implications for Public Health

Waugh¹

2019

IJERPH

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In this study, several lines of evidence are provided to show that Na + , K + -ATPase activity exerts vital roles in normal brain development and function and that loss of enzyme activity is implicated in neurodevelopmental, neuropsychiatric and neurodegenerative disorders, as well as increased risk of cancer, metabolic, pulmonary and cardiovascular disease. Evidence is presented to show that fluoride (F) inhibits Na + , K + -ATPase activity by altering biological pathways through modifying the expression of genes and the activity of glycolytic enzymes, metalloenzymes, hormones, proteins, neuropeptides and cytokines, as well as biological interface interactions that rely on the bioavailability of chemical elements magnesium and manganese to modulate ATP and Na + , K + -ATPase enzyme activity. Taken together, the findings of this study provide unprecedented insights into the molecular mechanisms and biological pathways by which F inhibits Na + , K + -ATPase activity and contributes to the etiology and pathophysiology of diseases associated with impairment of this essential enzyme. Moreover, the findings of this study further suggest that there are windows of susceptibility over the life course where chronic F exposure in pregnancy and early infancy may impair Na + , K + -ATPase activity with both short- and long-term implications for disease and inequalities in health. These findings would warrant considerable attention and potential intervention, not to mention additional research on the potential effects of F intake in contributing to chronic disease.

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Enhanced Oxidative Stress

Ran

Guan

2021

Coal-Burning Type of Endemic Fluorosis

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Alteration of paraoxonase, arylesterase and lactonase activities in people around fluoride endemic area of Tamil Nadu, India

Cited by 8 publications

References 48 publications

The Contribution of Fluoride to the Pathogenesis of Eye Diseases: Molecular Mechanisms and Implications for Public Health

The Contribution of Fluoride to the Pathogenesis of Eye Diseases: Molecular Mechanisms and Implications for Public Health

Fluoride Exposure Induces Inhibition of Sodium-and Potassium-Activated Adenosine Triphosphatase (Na+, K+-ATPase) Enzyme Activity: Molecular Mechanisms and Implications for Public Health

Enhanced Oxidative Stress

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