Alteration of platelet aggregation in patients with thyroid disorders

Masunaga, Rumi; Nagasaka, Akiomi; Nakai, Asami; Kotake, Motoko; Sawai, Yoshikuni; Oda, Naohisa; Mokuno, T; Shimazaki, Ken-ichiro; Hayakawa, Naohiro; Kato, Ryuzo; Hirano, Erika; Hagiwara, Masatoshi; Hidaka, Hiroyoshi

doi:10.1016/s0026-0495(97)90203-1

Cited by 31 publications

(15 citation statements)

References 7 publications

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“…6. Another possible mechanism linking SCH to vascular diseases is the finding that thyroid hormones inhibit collagen-induced platelet aggregation 6 and directly relax smooth muscles. 7.…”

Section: Discussionmentioning

confidence: 99%

A Case Control Study to Evaluate Thyroid Dysfunction as a Risk Factor for Diabetic Retinopathy in Type 2 Diabetes Mellitus

Chandrakumar¹,

Thiyagarajan²,

K³

et al. 2016

jemds

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This is a Case Control Study that was conducted among 100 Type 2 DM (Diabetes Mellitus) patients who attended the OP and the wards of Ophthalmology Department at Government Rajaji Hospital, Madurai, to assess the prevalence of thyroid dysfunction among Type 2 DM patients and whether thyroid dysfunction is associated with increased risk of retinopathy in Type 2 diabetes patients. Patients diagnosed with Type 2 DM on treatment for more than 5 years of diabetes mellitus and over 12 years of age were taken up for this study. Patients with known history of thyroid disorder, patients on drugs known to affect thyroid function like lithium, amiodarone, oral contraceptive pills, etc., pregnant mothers, systolic blood pressure more than 150 mm of Hg and diastolic more than 90 mm of Hg, with nephropathy and those patients for whom fundus examination was not possible, patients not consenting for this study were excluded from this study. Data and blood samples will be collected from subjects and serum shall be extracted for thyroid profile. All the study patients will undergo a detailed ocular examination for grading of Diabetic Retinopathy (DR) as per the Early Treatment Diabetic Retinopathy Study (ETDRS) guidelines. RESULTSOdds Ratio (OR) for determining association between risk factor and disease was 5.06, with an upper 95% Confidence Limit of 15.051 and a lower confidence limit of 1.703, which means the odds of a diabetic patient with thyroid dysfunction (subclinical and overt hypothyroidism) developing retinopathy is 5.06 times that of a diabetic patient without thyroid dysfunction. According to this study the prevalence of thyroid dysfunction among the 100 Type 2 Diabetes Mellitus patients studied was 23% with the most common problem being Subclinical Hypothyroidism (SCH) at 21% among the study population followed by overt hypothyroidism at 2%. As expected the prevalence of thyroid dysfunction 3 among females (32%) was much more than among males (14%), the odds ratio being 5.06. Chi-Square statistic applied to our data revealed P-value of <0.005. CONCLUSIONOur study showed a significant association between subclinical and overt hypothyroidism with development of diabetic retinopathy in this study population.

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“…6. Another possible mechanism linking SCH to vascular diseases is the finding that thyroid hormones inhibit collagen-induced platelet aggregation 6 and directly relax smooth muscles. 7.…”

Section: Discussionmentioning

confidence: 99%

A Case Control Study to Evaluate Thyroid Dysfunction as a Risk Factor for Diabetic Retinopathy in Type 2 Diabetes Mellitus

Chandrakumar¹,

Thiyagarajan²,

K³

et al. 2016

jemds

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“…Both increased and decreased platelet aggregation have been reported, with the degree of severity determining the impact on coagulation parameters [35, 36]. In moderate hypothyroidism (TSH 10–50 mU/L), fibrinolytic activity is reduced, with low d-dimers, increased α 2-antiplasmin activity, and higher levels of antigens to tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) [36].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Subclinical Hypothyroidism among Patients with Acute Myocardial Infarction

Okuyan

Uslu²,

Enhos

et al. 2011

ISRN Endocrinology

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Introduction. Subclinical hypothyroidism (SCH) is defined as a serum thyroid-stimulating hormone (TSH) level above the upper limit of normal despite normal levels of serum free thyroxine. There is growing evidence that SCH is associated with increased cardiovascular risk. We tried to investigate prevalence of SCH in acute myocardial infarction patients. Methods and Results. We evaluate free T3, free T4, and TSH levels of 604 patients (age 58.4) retrospectively, who have been admitted to the coronary intensive care unit between years 2004–2009 with the diagnosis of ST elevation (STEMI) or non-ST elevation acute myocardial infarction (NSTEMI). Mild subclinical hypothyroidism (TSH 4.5 to 9.9 mU/l) was present in 54 (8.94%) participants and severe subclinical hypothyroidism (TSH 10.0 to 19.9 mU/l) in 11 (1.82%). So 65 patients (10.76%) had TSH levels between 4.5 and 20. Conclusions. In conclusion, 65 patients (10.76%) had TSH levels between 4.5 and 20 in our study, and it is a considerable amount. Large-scale studies are needed to clarify the effects of SCH on myocardial infarction both on etiologic and prognostic grounds.

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“…Although our patient's clotting screen was normal, functional platelet abnormalities affecting primary haemostasis have previously been described (Masunaga et al, 1997), with significantly reduced platelet aggregation in patients with untreated Graves' disease. Furthermore, our patient's bleeding symptoms would be exacerbated by an increased plasma volume and hyperdynamic circulation (Leon-Sotomayor et al, 1966;Spivak, 2006) induced by her hyperthyroid state, which would also account for the mild microcytosis despite normal haemoglobin (Spivak, 2000).…”

Section: Commentmentioning

confidence: 51%