Alteration of primary cilia morphology and associated signalling in ameloblastoma

Filušová, Jana; Putnová, Iveta; Hurník, Pavel; Daněk, Zdeněk; Macháček, Ctirad; Štembírek, Jan; Buchtová, Marcela; Putnová, Barbora Moldovan

doi:10.1016/j.archoralbio.2022.105499

Cited by 5 publications

(4 citation statements)

References 47 publications

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“…Higher levels of Ki-67 correlate with higher levels of cell proliferation and may correlate with a higher rate of tumor recurrence. Another study showed "abundant" expression of primary cilia, indicative of Hedgehog signaling, in follicular and plexiform types, which were rarely expressed in basal ameloblastomas [32]. Additional studies showed gene expression profile differences between plexiform and follicular ameloblastomas, with follicular ameloblastomas expressing variants of BRAF, KMT2D, and ABL1, while plexiform ameloblastomas expressed variants of ALK, BRAF, KRAS, KMT2D, SMO, KMT2A, and BRCA2 [33,34].…”

Section: Discussionmentioning

confidence: 96%

“…The clinical significance of the histopathology of ameloblastoma is contentious amongst the literature. Some reports state it has no significance, others state that plexiform or follicular patterns are associated with higher rates of recurrence or the expression of certain markers [28][29][30][31][32][33][34]. Gupta et al reported plexiform ameloblastomas expressed significantly higher Ki-67 than follicular or acanthomatous types [31].…”

Section: Discussionmentioning

confidence: 99%

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A Retrospective Analysis of 129 Ameloblastoma Cases: Clinical and Demographical Trends from a Single Institution

Vila,

Oster,

James

et al. 2024

J. Racial and Ethnic Health Disparities

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Ameloblastomas are benign neoplasms of the jaw, but frequently require extensive surgery. The aim of the study was to analyze the demographic and clinicopathological features of ameloblastoma cases at a single Oral and Maxillofacial Surgery group in the United States. Study Design: A retrospective chart review of patients evaluated for ameloblastoma between 2010 and 2020 at a single tertiary care center. Age, race, sex, tumor size, tumor location, and histological subtypes were recorded. Results: A total of 129 cases of ameloblastoma were recorded with a mean patient age of 42 ± 18.6 years (range 9–91 years old), male to female ratio 1.08:1. Ameloblastoma presenting in the mandible outnumbered maxilla in primary (118 to 8, respectively) and recurrent cases (8 to 1, respectively). There was a higher prevalence of ameloblastoma in Black patients (61.3%) with mean age of Black patients occurring at 40.5 years and the mean age of White patients occurring at 47.8 years and mean tumor size trended larger in the Black patients (15.7 cm2) compared to White patients (11.8 cm2). Conclusion: Data suggests a strong influence of racial factors on the incidence of ameloblastoma, with regards to size, Black patients with ameloblastoma trended higher and more data is needed to clearly elucidate any relationship between the tumor size and race, as other factors may influence the size (such as time to discovery).

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

A Retrospective Analysis of 129 Ameloblastoma Cases: Clinical and Demographical Trends from a Single Institution

Vila,

Oster,

James

et al. 2024

J. Racial and Ethnic Health Disparities

View full text Add to dashboard Cite

show abstract

“…Members of our research team recently revealed that primary cilia are abundantly present also in the plexiform and follicular types of ameloblastoma, but only scarcely in its basal cell type form [ 18 ]. Ameloblastoma is an odontogenic tumor sharing some similarities with DCs to such a degree that distinguishing unicystic ameloblastomas associated with an impacted tooth from DCs is challenging even for pathologists [ 19 ].…”

Section: The Role Of Primary Cilia and Associated Signaling Pathways ...mentioning

confidence: 99%

“…It is also speculated that in some cases, it might aggravate the Gorlin-Goltz syndrome [ 90 ]. Sonidegib, another SHH inhibitor, might be another potential candidate for the treatment of OCs, as suggested by its effect on ameloblastoma formation [ 18 ]. Allopurinol might also deserve attention for the treatment of OCs – it was shown to interact with PKD2 and, therefore, it may affect lesions, in the development of which PKD2 plays a role [ 28 ].…”

Section: Future Perspectives and Clinical Implicationsmentioning

confidence: 99%

Primary cilia and hypoxia-associated signaling in developmental odontogenic cysts in relation to autosomal dominant polycystic kidney disease – A novel insight

Szaraz,

Danek,

Lipovy

et al. 2023

Heliyon

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Regulation of the Cilia as a Potential Treatment for Senescence and Tumors: A Review

Zhu,

Pan,

Yang

et al. 2024

Journal Cellular Physiology

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Millions of people worldwide die from malignant tumors every year, and the current clinical treatment is still based on radiotherapy and chemotherapy. Immunotherapy‐adjuvant chemotherapy is widely applied, yet resistance to various factors persists in the management of advanced malignancies. Recently researchers have gradually discovered that the integrity of primary cilia is closely related to many diseases. The phenotypic changes in primary cilia are found in some cases of progeria, tumorigenesis, and drug resistance. Primary cilia seem to mediate signaling during these diseases. Hedgehog inhibitors have emerged in recent years to treat tumors by controlling signaling proteins on primary cilia. There is evidence for the use of anti‐tumor drugs to treat senescence‐related disease. Considering the close relationship between aging and obesity, as well as the obesity is the phenotype of many ciliopathies. Therefore, we speculate that some anti‐tumor or anti‐aging drugs can treat ciliopathies. Additionally, there is evidence suggesting that anti‐aging drugs for tumor treatment, in which the process may be mediated by cilia. This review elucidates for the first time that cilia may be involved in the regulation of senescence, metabolic, tumorigenesis, and tumor resistance and hypothesizes that cilia can be regulated to treat these diseases in the future.

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Alteration of primary cilia morphology and associated signalling in ameloblastoma

Cited by 5 publications

References 47 publications

A Retrospective Analysis of 129 Ameloblastoma Cases: Clinical and Demographical Trends from a Single Institution

A Retrospective Analysis of 129 Ameloblastoma Cases: Clinical and Demographical Trends from a Single Institution

Primary cilia and hypoxia-associated signaling in developmental odontogenic cysts in relation to autosomal dominant polycystic kidney disease – A novel insight

Regulation of the Cilia as a Potential Treatment for Senescence and Tumors: A Review

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