Alteration of Serum Phospholipid n‐6 Polyunsaturated Fatty Acid Compositions in <scp>Nonalcoholic</scp> Fatty Liver Disease in the Japanese Population: A Cross‐Sectional Study

Jiang, Zhe; Hayashi, Takuya; Kashima, Kentaro; Kurotani, Kayo; Shirouchi, Bungo; Mizoue, Tetsuya

doi:10.1002/lipd.12251

Cited by 4 publications

(1 citation statement)

References 59 publications

(75 reference statements)

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“…Blood ALT concentration is positively correlated with liver weight (Jiang Z et al., 2020). The SAP elevated the weight of liver in mice, explaining why serum ALT levels were increased by the SAP.…”

Section: Resultsmentioning

confidence: 99%

Soyasaponin ameliorates obesity and reduces hepatic triacylglycerol accumulation by suppressing lipogenesis in high‐fat diet‐fed mice

Tsai

Nakamura

Akasaka

et al. 2021

Journal of Food Science

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Soyasaponins are triterpenoid glycosides found in soybean. We investigated whether soyasaponin ameliorates lipid metabolism and its possible mechanisms. In C57BL/6J mice fed a high‐fat diet (HFD), soyasaponin (SAP) was orally administered for 9 weeks. Additionally, we evaluated the effect of soyasapogenols on 3T3‐L1 adipocytes. In HFD‐fed mice, the SAP significantly reduced body weight by 7% and relative adipose tissue weight by 35%. X‐ray computed tomography demonstrated that the SAP reduced visceral and subcutaneous adipose tissue weights during week 3 of feeding. The SAP reduced sterol regulatory element‐binding protein‐1c (SREBP‐1c) mRNA levels by 32% in the epididymal adipose tissue, significantly decreasing the triacylglycerol (TAG) content by 37% and SREBP‐1c and fatty acid synthase mRNA levels by 52% and 61%, respectively, in the liver. In 3T3‐L1 adipocytes, soyasapogenol B significantly decreased lipid droplets. The SAP containing soyasaponin A and B as conjugates demonstrate anti‐obesity effects by suppressing adipocyte differentiation and lipogenesis, with a preventive effect on hepatic TAG accumulation by suppressing lipogenesis. Practical Application Soyasaponin is one of the oleanane triterpenoids in soybeans. We have demonstrated that soyasaponin potently reduces body weight and white adipose tissue weight, and hepatic triacylglycerol accumulation in high‐fat diet‐fed mice. Thus, soyasaponin is a beneficial compound to prevent obesity and fatty liver.

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Section: Resultsmentioning

confidence: 99%

Soyasaponin ameliorates obesity and reduces hepatic triacylglycerol accumulation by suppressing lipogenesis in high‐fat diet‐fed mice

Tsai

Nakamura

Akasaka

et al. 2021

Journal of Food Science

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Dietary egg white protein hydrolysate improves orotic acid-induced fatty liver in rats by promoting hepatic phospholipid synthesis and microsomal triglyceride transfer protein expression

Jiang¹,

Kimura²,

Shirouchi³

et al. 2021

The Journal of Nutritional Biochemistry

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Soluble Fiber Inulin Consumption Limits Alterations of the Gut Microbiota and Hepatic Fatty Acid Metabolism Caused by High-Fat Diet

et al. 2021

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Diet shapes the gut microbiota which impacts hepatic lipid metabolism. Modifications in liver fat content are associated with metabolic disorders. We investigated the extent of dietary fat and fiber-induced alterations in the composition of gut microbiota and hepatic fatty acids (FAs). Mice were fed a purified low-fat diet (LFD) or high-fat diet (HFD) containing non-soluble fiber cellulose or soluble fiber inulin. HFD induced hepatic decreases in the amounts of C14:0, C16:1n-7, C18:1n-7 and increases in the amounts of C17:0, C20:0, C16:1n-9, C22:5n-3, C20:2n-6, C20:3n-6, and C22:4n-6. When incorporated in a LFD, inulin poorly affected the profile of FAs. However, when incorporated in a HFD, it (i) specifically led to an increase in the amounts of hepatic C18:0, C22:0, total polyunsaturated FAs (PUFAs), total n-6 PUFAs, C18:3n-3, and C18:2n-6, (ii) exacerbated the HFD-induced increase in the amount of C17:0, and (iii) prevented the HFD-induced increases in C16:1n-9 and C20:3n-6. Importantly, the expression/activity of some elongases and desaturases, as well as the gut microbiota composition, were impacted by the dietary fat and fiber content. To conclude, inulin modulated gut microbiota and hepatic fatty acid composition, and further investigations will determine whether a causal relationship exists between these two parameters.

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Alteration of Serum Phospholipid n‐6 Polyunsaturated Fatty Acid Compositions in Nonalcoholic Fatty Liver Disease in the Japanese Population: A Cross‐Sectional Study

Cited by 4 publications

References 59 publications

Soyasaponin ameliorates obesity and reduces hepatic triacylglycerol accumulation by suppressing lipogenesis in high‐fat diet‐fed mice

Soyasaponin ameliorates obesity and reduces hepatic triacylglycerol accumulation by suppressing lipogenesis in high‐fat diet‐fed mice

Dietary egg white protein hydrolysate improves orotic acid-induced fatty liver in rats by promoting hepatic phospholipid synthesis and microsomal triglyceride transfer protein expression

Soluble Fiber Inulin Consumption Limits Alterations of the Gut Microbiota and Hepatic Fatty Acid Metabolism Caused by High-Fat Diet

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