Alteration of Some Inflammatory Biomarkers by Dietary Oxysterols in Rats

Soto-Rodríguez, Ida; Alexander‐Aguilera, Alfonso; Zamudio-Pérez, Antonio; Camara-Contreras, Mireya; Hernández-Diaz, Guillermo; Garcı́a, Hugo S.

doi:10.1007/s10753-012-9442-9

Cited by 7 publications

(6 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been mentioned above that different cardiovascular risk factors, such as hypertriglyceridemia, hypertension, diabetes, obesity and overweight, have been associated to COPs content in human serum [ 15 ]. In agreement with these results, COPs induced increased blood pressure, serum triacylgycerols as well as body fat index in Wistar rats [ 59 ]. On the other hand, the induction of hypertension to rabbits by coarctation of the aorta showed an enhancement of COPs content in both plasma and aortic tissue [ 60 ].…”

Section: Discussionsupporting

confidence: 71%

Dietary docosahexaenoic acid supplementation prevents the formation of cholesterol oxidation products in arteries from orchidectomized rats

et al. 2017

View full text Add to dashboard Cite

Testosterone deficiency has been correlated with increased cardiovascular diseases, which in turn has been associated with increased oxidative stress. Several studies have considered cholesterol oxidation products (COPs) as oxidative stress biomarkers, since some of them play pro-oxidant and pro-inflammatory roles. We have previously described the cardioprotective effects of a dosahexaenoic acid (DHA) supplemented diet on the aortic and mesenteric artery function of orchidectomized rats. The aim of this study was to investigate whether impaired gonadal function alters the formation of COPs, as well as the potential preventive role of a DHA-supplemented diet on that effect. For this purpose, aortic and mesenteric artery segments obtained from control and orchidectomized rats, fed with a standard or supplemented with DHA, were used. The content of the following COPs: 7α-hydroxycholesterol, 7β-hydroxycholesterol, 7-ketocholesterol, 5,6α-epoxycholesterol, 5,6β-epoxycholesterol, cholestanetriol and 25-hydroxycholesterol, were analyzed by gas chromatography. The results showed that orchidectomy increased the formation of COPs in arteries from orchidectomized rats, which may participate in the orchidectomy-induced structural and functional vascular alterations already reported. The fact that the DHA-supplemented diet prevented the orchidectomy-induced COPs increase confirms the cardiovascular protective actions of DHA, which could be of special relevance in mesenteric arterial bed, since it importantly controls the systemic vascular resistance.

show abstract

Section: Discussionsupporting

confidence: 71%

Dietary docosahexaenoic acid supplementation prevents the formation of cholesterol oxidation products in arteries from orchidectomized rats

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Antioxidant potential of zinc can be the reason for lower content of total COPs in groups receiving dietary supplements, by influencing the formation of COPs which are produced under oxidative stress. It is broadly known that some oxysterols (7-K-Ch, 7α-hydroxycholesterol (7α-OH-Ch), 7β-OH-Ch, 5α6α-epoxidecholesterol, 5,6βE-Ch, 25-hydroxycholesterol), have potent pro-inflammatory properties [ 22 , 34 , 35 ]. Inflammation contributes to the development of many disease entities.…”

Section: Discussionmentioning

confidence: 99%

Zinc Affects Cholesterol Oxidation Products and Fatty Acids Composition in Rats’ Serum

et al. 2021

View full text Add to dashboard Cite

The purpose of this work was to evaluate the effect of the nanosized or microsized zinc (Zn) particles on fatty acid profile, enzyme activity and the level of cholesterol, squalene and oxysterols in rats with breast cancer. Rats (female, n = 24) were divided into the following groups: control, and two test groups, whose diets were enriched with either Zn microparticles (342 nm) or Zn nanoparticles (99 nm). All rats were treated twice with the carcinogenic agent; 7,12-dimethylbenz[a]anthracene. In rats whose diet was enriched with zinc (especially in the form of nanoparticles), the number and sizes of tumors were lower. Diet supplementation also significantly reduced the cholesterol (P = 0.027) and COPs (cholesterol oxidation products) levels (P = 0.011) in rats serum. Enriching the diet with Zn microparticles decreased the Δ6-desaturase activity (P < 0.001). Zn influences fatty acids’ profile in rats’ serum as well as inhibiting desaturating enzymes. A reduced amount of pro-inflammatory arachidonic acid derivatives may be the expected effect.

show abstract

“…Therefore, the occurrence in foods and the subsequent dietary intake not only of intact cholesterol but also of cholesterol oxidation products has been in the focus of recent research activities. An increased intake of dietary cholesterol oxidation products was shown to be associated with impaired hepatic function and lipid metabolism and ultimately atherosclerotic progression in various animal models [31][32][33][34][35][36][37][38][39].…”

Section: Introductionmentioning

confidence: 99%

Phytosterol oxidation products in enriched foods: Occurrence, exposure, and biological effects

Scholz

Guth

Engel

et al. 2015

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Hypercholesterolemia is an important risk factor for the development of cardiovascular diseases. Dietary intake of phytosterols/phytostanols and their fatty acid esters results in a reduction of the LDL and total plasma cholesterol levels. Therefore, these constituents are added to a broad spectrum of foods. As in the case of cholesterol, thermo-oxidative treatment of phytosterols may result in the formation of phytosterol oxidation products (POPs), i.e. keto-, hydroxy-, and epoxy-derivatives. This review summarizes and evaluates the current knowledge regarding POPs in the light of the potentially increasing dietary exposure to these constituents via the consumption of foods enriched with phytosterols/phytostanols and their esters. Data on the occurrence of POPs and approaches to assess the potential intake of POPs resulting from the consumption of enriched foods are described. The knowledge on the uptake of POPs and the presently available data on the impact of the consumption of enriched foods on the levels of POPs in humans are discussed. Biological effects of POPs, such as potential proatherogenic properties or the loss of the cholesterol-lowering effects compared to nonoxidized phytosterols, are discussed. Finally, knowledge gaps are outlined and recommendations for further research needed for a safety assessment of POPs are presented.

show abstract

Alteration of Some Inflammatory Biomarkers by Dietary Oxysterols in Rats

Cited by 7 publications

References 36 publications

Dietary docosahexaenoic acid supplementation prevents the formation of cholesterol oxidation products in arteries from orchidectomized rats

Dietary docosahexaenoic acid supplementation prevents the formation of cholesterol oxidation products in arteries from orchidectomized rats

Zinc Affects Cholesterol Oxidation Products and Fatty Acids Composition in Rats’ Serum

Phytosterol oxidation products in enriched foods: Occurrence, exposure, and biological effects

Contact Info

Product

Resources

About