Alteration of the Clinical Picture during Tofrānil Therapy<sup />

Berthiaume, Marcel

doi:10.1177/070674375900401s20

Cited by 3 publications

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“…Antidepressant drugs have "paradoxically" induced a deepening of depressive affect (Cole, Griffith, and Kaye 1965;DiMascio, Meuer, and Stifler 1968), and the imipramines (Berthiaume 1959;Fotel-Andersen and Geert-Jorgensen 1959;Hohn et aZ. 1961;Pilkington 1962;Rikovsky 1964;Klein 1965) , ~itriptyline (Hudgens et aZ.…”

Section: Behavioral Toxicitymentioning

confidence: 99%

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Brain Chemistry and Mental Disease

Ho¹,

McIsaac²

1971

Advances in Behavioral Biology

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PREFACEThis volume contains the proceedings of the fourth international symposium held in November 1970 at the Texas Research Institute of Mental Sciences in Houston. Leading psychiatrists, biochemists, and pharmacologists from the United States and Great Britain presented new material and reviewed current concepts concerning schizophrenia and the affective disorders, with particular reference to the neurochemical basis of the etiology and chemotherapy of these diseases.Although the multiple mechanisms of mental disease are still not fully understood, substantial progress has definitely been made. The greatest contribution has come through the development of new therapeutic agents that not only provide invaluable help to the mentally ill but serve as chemical tools for studying the biological mechanisms associated with the disease state. Studies concerning the proposed catecholamine and indolealkylamine hypotheses for affective disorders and the possible formation of endogenous. toxins in schizophrenia have stimulated significant new research.This book presents new studies of schizophrenia and the affective disorders in one volume. It is our hope that it represents an effective integration of basic biochemical and pharmacological research with current clinical findings and that it will increase understanding of the etiology of mental disease and provide an impetus for the development of more effective therapeutic agents.We thank Drs.

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Section: Behavioral Toxicitymentioning

confidence: 99%

“…Antidepressant agents can have a pendular effect on gross behavior patterns as well. The mood-elevating and stimulating properties of imipramine (Berthiaume 1959;Hohn et aZ. 1961;Brune and Himwich 1963;Klein 1965), nortryptamine (Sarwer-Foner et aZ.…”

Section: Behavioral Toxicitymentioning

confidence: 99%