Alteration of the sialylation pattern of the murine tooth germ after ethanol exposure

Jiménez-Farfán, Dolores; Guevara, Jorge; Zenteno, Edgar; Hernández‐Guerrero, Juan Carlos

doi:10.1002/bdra.20198

Cited by 5 publications

(2 citation statements)

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“…For example, animal research has shown that ethanol (alcohol) can lead to changes in cellular differentiation and enamel mineralisation [38]. Our observed association of alcohol consumption during pregnancy with enamel hypomineralisation has not been reported before and needs further exploration.…”

Section: Discussionmentioning

confidence: 46%

Pre- and Postnatal Determinants of Deciduous Molar Hypomineralisation in 6-Year-Old Children. The Generation R Study

et al. 2014

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BackgroundDeciduous Molar Hypomineralisation (DMH) and Molar Incisor Hypomineralisation (MIH) are common developmental disturbances in pediatric dentistry. Their occurrence is related. The same determinants as suggested for MIH are expected for DMH, though somewhat earlier in life. Perinatal medical problems may influence the prevalence of DMH but this has not been studied sufficiently.ObjectiveThis study aimed to identify possible determinants of DMH in a prospective cohort study among 6-year-old children.Study DesignThis study was embedded in the Generation R Study, a population-based prospective cohort study from fetal life until young adulthood. The the data were used to identify the determinants of DMH. Clinical photographs of clean, moist teeth were taken with an intra-oral camera in 6690 children (mean age 6.2 years; 49.9% girls). Data on possible determinants that had occurred during pregnancy and/or the child's first year of life were on the basis of manual standardized measurements (like length and weight) and questionnaires. Multivariate analyse with backward and forward selection was performed.ResultsA number of factors in the pre-, peri- and postnatal phase were found to be associated with DMH. After multivariate logistic regression analyses, Dutch ethnic background, low birth weight, maternal alcohol consumption during pregnancy, and fever episodes in the first year of the child's life were found to play a role in the development of DMH in 6-year-old children.ConclusionThis study shows that Dutch ethnicity, low birth weight, alcohol consumption by the mother during pregnancy and any fever in the first year of the child's life are associated with DMH. Not only childhood factors but also prenatal lifestyle factors need to be taken into account when studying determinants for DMH.

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Section: Discussionmentioning

confidence: 46%

Pre- and Postnatal Determinants of Deciduous Molar Hypomineralisation in 6-Year-Old Children. The Generation R Study

et al. 2014

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“…Pelo fato de ter sido encontrado uma alta prevalência de opacidades demarcadas, há de se ter preocupação futura com a saúde bucal desta população, pois como já foi evidenciado em estudos populacionais, crianças que possuem opacidades demarcadas em dentes decíduos apresentam maior probabilidade de ter HMI em dentes permanentes (da Costa-Silva et al, 2010;Elfrink et al, 2012;Garot et al, 2018;Tourino et al, 2018;Reyes et al, 2019 é o estágio de desenvolvimento dentário no momento da atuação do insulto (Seow, 2015 -Farfan et al, 2005).…”

Section: Discussionunclassified

Estudo epidemiológico dos defeitos de desenvolvimento do esmalte em crianças de 2 a 4 anos de idade do município de Santa Isabel, SP

Carvalho¹

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Carvalho P. Epidemiological study of developmental enamel defects in children aged 2 to 4 years in the municipality of Santa Isabel, SP. [thesis]. São Paulo: Universidade de São Paulo, Faculdade de Odontologia; 2020. Versão Corrigida. The disorders that occur during enamel formation of primary teeth that manifest as Developmental Enamel Defects (DDE) have an important clinical significance, as they are responsible for aesthetic problems, occlusion disorders, dentin sensitivity and they can act as a predisposing factor to tooth decay and a predictor of molar incisor hypomineralization. These possible clinical implications can negatively impact the oral health-related quality of life (OHRQoL) of children with DDE. The aim of the present study was to know the prevalence and severity of DDE in primary teeth, to identify the etiological factors associated with the defects of enamel and to assess the impact of DDE in OHRQoL. The study evaluated 336 children aged 2 to 4 years in the municipality of Santa Isabel, São Paulo who attended the National Day of Children Vaccination. For the diagnosis of DDE, the extent, location, color of the defect were evaluated and the type of defect was also determined using the modified DDE index recommended by the International Dental Federation. Mothers or legal caregivers answered the Brazilian version of the Early Childhood Oral Health Impact Scale (B-ECOHIS), socio-demographic and the pre, peri and post-natal conditions questionnaires. To assess the impact of DDE on OHRQoL, data were collected using the Brazilian version of the ECOHIS questionnaire. Descriptive analyzes, Kappa test, chi-square test, Kolgomorov Smirnov normality test, Wilcoxon test, unadjusted and adjusted Poisson regression analyzes (α = 0.05) were performed. The prevalence of DDE was 50.60%. Demarcated (45.0%) and diffuse (36.0%) opacities of white / cream color were the most frequent defects. Molars were the teeth most affected, and among the surfaces examined, the buccal surfaces were the most affected. There was an association between DDE and alcohol consumption during pregnancy (p = 0.022), hospitalization of the child in the first year of life for infectious diseases (p = 0.010) and dental caries (p = 0.022). Children who were breastfed for 12 months had a lower risk of developing DDE (p = 0.022). Yellow-brown opacities were more likely to have a negative impact on the symptom and limitation domains (p <0.05) and on the parents' distress domain (p <0.05). It can be concluded that DDE have high prevalence and mild severity. Alcohol consumption during pregnancy and the child's hospitalization for infectious diseases in the first year of life are risk factors for DDE in primary dentition. Breastfeeding for a period of 12 months is a protective factor for the development of DDE in the primary dentition. The demarcated yellow-brown opacities have an negative impact on the OHRQoL of children aged 2 to 4 years, according to the parents' reports.

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Prenatal, perinatal and postnatal events associated with hypomineralized second primary molar: a systematic review with meta-analysis

2021

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Alteration of the sialylation pattern of the murine tooth germ after ethanol exposure

Cited by 5 publications

References 63 publications

Pre- and Postnatal Determinants of Deciduous Molar Hypomineralisation in 6-Year-Old Children. The Generation R Study

Pre- and Postnatal Determinants of Deciduous Molar Hypomineralisation in 6-Year-Old Children. The Generation R Study

Estudo epidemiológico dos defeitos de desenvolvimento do esmalte em crianças de 2 a 4 anos de idade do município de Santa Isabel, SP

Prenatal, perinatal and postnatal events associated with hypomineralized second primary molar: a systematic review with meta-analysis

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