Alteration of the state of the human tibia during antiorthostatic hypokinesis

Tatarinov, Alexey; Григорьев, А. И.; Dzenis, V. V.; Yanson, Kh. A.; Оганов, В. С.; Rakhmanov, A. S.

doi:10.1007/bf00606018

Cited by 4 publications

(5 citation statements)

References 2 publications

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“…This wave travelled close to the Rayleigh velocity in thick plates, with velocity decreasing strongly with decreasing thickness in excellent agreement with the predictions for the Lamb A0 wave. The A0 wave is essentially a flexural wave (Graff 1991), and is likely to have been the type of wave measured previously by others in the tibia (Jansons et al 1984, Oranov et al 1988, Tatarinov et al 1990. Comparing the (r, t) diagrams for acrylic and tibial measurements, the same qualitative features were observed (a small-amplitude first arriving signal and a larger amplitude second slower wave) which suggests that the same phenomena were involved.…”

Section: Discussionsupporting

confidence: 64%

“…In general, little consideration has been given to the possibility of using different types of ultrasonic waves in long bones. One exception has been a series of studies reporting low-frequency ultrasonic measurements of 'surface wave' velocity in the tibia, mapping the spatial variation in velocity and quantifying changes during weightlessness (Jansons et al 1984, Oranov et al 1988, Tatarinov et al 1990, McCarthy et al 2000. However, since pure surface waves only exist in structures that are much thicker than the wavelength, it is likely that these researchers were actually measuring a guided wave mode reflecting both bone thickness and material properties.…”

Section: Introductionmentioning

confidence: 99%

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Guided ultrasonic waves in long bones: modelling, experiment andin vivoapplication

et al. 2002

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Existing ultrasound devices for assessing the human tibia are based on detecting the first arriving signal, corresponding to a wave propagating at, or close to, the bulk longitudinal velocity in bone. However, human long bones are effectively irregular hollow tubes and should theoretically support the propagation of more complex guided modes similar to Lamb waves in plates. Guided waves are attractive because they propagate throughout the bone thickness and can potentially yield more information on bone material properties and architecture. In this study, Lamb wave theory and numerical simulations of wave propagation were used to gain insights into the expected behaviour of guided waves in bone. Experimental measurements in acrylic plates, using a prototype low-frequency axial pulse transmission device, confirmed the presence of two distinct propagating waves: the first arriving wave propagating at, or close to, the longitudinal velocity, and a slower second wave whose behaviour was consistent with the lowest order Lamb antisymmetrical (A0) mode. In a pilot study of healthy and osteoporotic subjects, the velocity of the second wave differed significantly between the two groups, whereas the first arriving wave velocity did not, suggesting the former to be a more sensitive indicator of osteoporosis. We conclude that guided wave measurements may offer an enhanced approach to the ultrasonic characterization of long bones.

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Section: Discussionsupporting

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Guided ultrasonic waves in long bones: modelling, experiment andin vivoapplication

et al. 2002

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“…The remarkable opportunity to investigate the influence of unloading of the ultrasonic profiles in the tibia was presented in experiments on long-term antiorthostatic hypokinesia, ANOG-120 (120-d bed rest) and ANOG-370 (370-d bed rest) conducted in the Institute of Medical and Biological Problems (Moscow) in the 1980s [46]. Volunteers were divided into groups of control, physical therapy, pharmacological therapy, and combined therapy.…”

Section: Alterations Of Axial Profiles Caused By Vital Factorsmentioning

confidence: 99%

Topography of acoustical properties of long bones: from biomechanical studies to bone health assessment

Tatarinov

Sarvazyan

2008

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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The article presents a retrospective view on the assessment of long bones condition using topographical patterns of the acoustic properties. The application of ultrasonic point-contact transducers with exponential waveguides on a short acoustic base for detailed measurements in human long bones by the surface transmission was initiated during the 1980s in Latvia. The guided wave velocity was mapped on the surface of the long bones and the topographical patterns reflected the biomechanical peculiarities. Axial velocity profiles obtained in vivo by measurements along the medial surface of tibia varied due to aging, hypokinesia, and physical training. The method has been advanced at Artann Laboratories (West Trenton, NJ) by the introduction of multifrequency data acquisition and axial scanning. The model studies carried out on synthetic phantoms and in bone specimens confirmed the potential to evaluate separately changes of the bone material properties and of the cortical thickness by multifrequency acoustic measurements at the 0.1 to 1 MHz band. The bone ultrasonic scanner (BUSS) is an axial mode ultrasonometer developed to depict the acoustic profile of bone that will detect the onset of bone atrophy as a spatial process. Clinical trials demonstrated a high sensitivity of BUSS to osteoporosis and the capability to assess early stage of osteopenia.

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“…They used an ultrasonic system originally developed for non-destructive testing of construction materials. The topographical variation of acoustic properties of long bones, particularly the velocity of slowly propagating flexural waves, was shown to be highly sensitive to the conditions of the bones [17-19]. …”

Section: Introductionmentioning

confidence: 99%

Multi-frequency axial transmission bone ultrasonometer

et al. 2014

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The last decade has seen a surge in the development of axial transmission QUS (Quantitative UltraSound) technologies for the assessment of long bones using various modes of acoustic waves. The condition of cortical bones and the development of osteoporosis are determined by numerous mechanical, micro-structural, and geometrical or macro-structural bone properties like hardness, porosity and cortical thickness. Such complex manifestations of osteoporosis require the evaluation of multiple parameters with different sensitivities to the various properties of bone that are affected by the disease. This objective may be achieved by using a multi-frequency ultrasonic examination The ratio of the acoustic wavelength to the cortical thickness can be changed by varying the frequency of the ultrasonic pulse propagating through the long bone that results in the change in composition of the induced wave comprised of a set of numerous modes of guided, longitudinal, and surface acoustic waves. The multi-frequency axial transmission QUS method developed at Artann Laboratories (Trenton, NJ) is implemented in the Bone Ultrasonic Scanner (BUSS). In the current version of the BUSS, a train of ultrasonic pulses with 60, 100, 400, 800, and 1200 kHz frequencies is used. The developed technology was tested on a variety of bone phantoms simulating normal, osteopenic, and osteoporotic bones. The results of this study confirm the feasibility of the multi-frequency approach for the assessment of the processes leading to osteoporosis.

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Alteration of the state of the human tibia during antiorthostatic hypokinesis

Cited by 4 publications

References 2 publications

Guided ultrasonic waves in long bones: modelling, experiment andin vivoapplication

Guided ultrasonic waves in long bones: modelling, experiment andin vivoapplication

Topography of acoustical properties of long bones: from biomechanical studies to bone health assessment

Multi-frequency axial transmission bone ultrasonometer

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