Alteration of the vascular supply in the rabbit ciliary body by transscleral diode laser cyclophotocoagulation

Schlote, Torsten; Beck, Jörg; Rohrbach, Jens Martin; Funk, Richard

doi:10.1007/pl00007898

Cited by 24 publications

(18 citation statements)

References 23 publications

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“…Multiple studies suggest that this is likely the case. Coagulation of the stroma and vasculature of the ciliary body was noted histologically in this study as well as in studies of laser effects on the ciliary body in rabbits . In dogs, ciliary body necrosis and hemorrhage were documented at 7 days and ciliary body atrophy and fibrosis at 28 days after TSCPC .…”

Section: Discussionsupporting

confidence: 53%

The location of sites and effect of semiconductor diode trans‐scleral cyclophotocoagulation on the buphthalmic equine globe

Gemensky-Metzler

Wilkie

Weisbrode

et al. 2014

Veterinary Ophthalmology

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Purpose To determine appropriate location and energy settings for transscleral cyclophotocoagulation (TSCPC) for buphthalmic equine globes. Animals Eleven horses with a buphthalmic eye blinded by glaucoma presented for enucleation. Methods Globe and corneal dimensions were measured via ultrasonography and calipers and TSCPC was performed under general anesthesia immediately prior to enucleation. Part 1: In 9 globes, sixty sites were lasered 4 mm posterior to the limbus in the dorsotemporal and ventrotemporal quadrants at settings of 1500 milliwatts and 1500 milliseconds. Globes were processed and sectioned sagitally over the temporal aspect in two blocks, each with 5 histologic sections examined by light microscopy. A digital imaging system was used to determine the location and length of the pars plicata on one slide from each block. Part 2: Based on results in Part 1, two globes were measured and lasered using the same time and energy settings at the following distances posterior to the limbus: 8 mm dorsally, 6 mm dorsotemporally, 5 mm ventrotemporally, 5 mm ventrally. Results Globe and corneal dimensions exceeded normal values in all globes. Part 1: In all 9 globes photocoagulation affected the anterior ciliary processes and iris base and in 8/9 coagulation of the pectinate ligaments was noted. Part 2: In both globes, coagulation was confined to the pars plicata. Conclusions The previously recommended TSCPC sites are located too far anteriorly for a buphthalmic globe. Buphthalmic equine globes should have TSCPC performed at the following distances posterior to the limbus: 6-8 mm dorsally, 5-6 mm dorsotemporally, 4-5 mm ventrotemporally and 4-5 mm ventrally.

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Section: Discussionsupporting

confidence: 53%

The location of sites and effect of semiconductor diode trans‐scleral cyclophotocoagulation on the buphthalmic equine globe

Gemensky-Metzler

Wilkie

Weisbrode

et al. 2014

Veterinary Ophthalmology

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“…19 The laser tip of the G-probe was placed at the limbus since the pigmented rabbit's ciliary processes are located more anteriorly than in the human. [20][21][22] Seven to eight shots were applied over the 100 degrees of limbus.…”

Section: Diode Tcpmentioning

confidence: 99%

Vascular effects on ciliary tissue from endoscopic versus trans-scleral cyclophotocoagulation

Lin

Chen²,

Lin³

et al. 2006

British Journal of Ophthalmology

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“…Each eye was imaged for pre-treatment blood flow, treated, and imaged again within 1 hour post-treatment. The eyes were also imaged at other time points ranging from 12-118 days to study potential vascular remodelling observed elsewhere [2].…”

Section: Treatment Protocolsmentioning

confidence: 99%

“…Elsewhere it has been shown that blood flow can be significantly reduced or completely stopped in cutaneous blood vessels smaller than 30 µm after exposure to pulsed laser radiation [3]. Another study using diode laser CPC showed significant alterations in microcasts of rabbit ciliary body microvasculature, including vessel rarefaction and destruction [2]. Extrapolation of these results to blood flow in ciliary processes suggests that it will be significantly reduced following laser CPC.…”

Section: Introductionmentioning

confidence: 99%

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High frequency ultrasound with an eigen-decomposition filter to assess the effect of laser cyclophotocoagulation treatment on blood flow

Kruse¹,

Lim²,

Redline

et al.

2002 IEEE Ultrasonics Symposium, 2002. Proceedings.

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We use high frequency ultrasound to assess the effect of laser cyclophotocoagulation (CPC) on blood flow in the anterior segment of the eye. We show that laser CPC treatment applied to the rabbit eye provides a unique way to interrupt blood flow in the ciliary body, thus serving as a new method for evaluating clutter rejection performance in the microcirculation with and without an ultrasound contrast agent. We apply a recently developed eigendecomposition-based clutter rejection filter with modifications to deal with high blood-to-clutter ratio's (BCR) encountered at high frequencies, particularly with ultrasound contrast agents. In vivo results are presented to illustrate treatment effects, clutter rejection, and contrast agent enhancement.

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Alteration of the vascular supply in the rabbit ciliary body by transscleral diode laser cyclophotocoagulation

Cited by 24 publications

References 23 publications

The location of sites and effect of semiconductor diode trans‐scleral cyclophotocoagulation on the buphthalmic equine globe

The location of sites and effect of semiconductor diode trans‐scleral cyclophotocoagulation on the buphthalmic equine globe

Vascular effects on ciliary tissue from endoscopic versus trans-scleral cyclophotocoagulation

High frequency ultrasound with an eigen-decomposition filter to assess the effect of laser cyclophotocoagulation treatment on blood flow

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