Alteration of Vascular Responsiveness to Uridine Adenosine Tetraphosphate in Aortas Isolated from Male Diabetic Otsuka Long-Evans Tokushima Fatty Rats: The Involvement of Prostanoids

Matsumoto, Takayuki; Kobayashi, Shota; Ando, Makoto; Iguchi, Maika; Takayanagi, Keisuke; Kojima, Mihoka; Taguchi, Kumiko; Kobayashi, Tsuneo

doi:10.3390/ijms18112378

Cited by 15 publications

(27 citation statements)

References 68 publications

(197 reference statements)

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“…Using Otsuka Long-Evans Tokushima Fatty (OLETF) type 2 diabetic rats, a strain that gradually develops high blood glucose after birth with obesity, thereby resembling human type 2 diabetes with obesity [108], Matsumoto et al investigated the vascular effects of Up 4 A in aortas and renal arteries. Up 4 A-induced contraction was decreased in aortas of the OLETF rat as compared to control LETO rats at baseline without preconstriction [72]. The decreased contraction may provide a compensatory mechanism to counteract the hypervascular contractility present in diabetes and hypertension.…”

Section: Diabetesmentioning

confidence: 81%

“…The decreased contraction may provide a compensatory mechanism to counteract the hypervascular contractility present in diabetes and hypertension. With elevated tone, Up 4 A produced a mild relaxation in aortas from OLETF rats as compared to the vasoconstrictor effect in LETO rats [72]. In healthy LETO rats in the absence and presence of preconstriction, the endothelium predominantly released vasoconstrictors i.e.…”

Section: Diabetesmentioning

confidence: 84%

“…In contrast to Sprague Dawley rats, Up 4 A-induced contraction was endothelium-dependent [72]. Moreover, upon PE-induced preconstriction, Up 4 A produced a concentration-dependent contraction, which was further enhanced by NOS blockade, while Up 4 A induced relaxation in the presence of cyclooxygenase (COX) inhibition [72]. Hence, studies in both Sprague Dawley and LETO rats indicate that there is an endothelium-dependent attenuation of Up 4 A-induced vasoconstriction.…”

Section: Matsumoto Et Al Found a Similar Contraction Pattern Inducedmentioning

confidence: 92%

“…from Long-Evans Tokushima Otsuka rats (LETO), a control to type 2 diabetic Otsuka Long-Evans Tokushima Fatty rats (OLETF). In contrast to Sprague Dawley rats, Up 4 A-induced contraction was endothelium-dependent [72]. Moreover, upon PE-induced preconstriction, Up 4 A produced a concentration-dependent contraction, which was further enhanced by NOS blockade, while Up 4 A induced relaxation in the presence of cyclooxygenase (COX) inhibition [72].…”

Section: Matsumoto Et Al Found a Similar Contraction Pattern Inducedmentioning

confidence: 95%

“…Hence, studies in both Sprague Dawley and LETO rats indicate that there is an endothelium-dependent attenuation of Up 4 A-induced vasoconstriction. The difference in vascular effect between these two rat strains may be due to increased generation of predominant vasoconstrictor prostanoids PGF2α and thromboxane (TxA2) over the vasodilator prostanoid PGE2 in the LETO rats [72].…”

Section: Matsumoto Et Al Found a Similar Contraction Pattern Inducedmentioning

confidence: 99%

See 4 more Smart Citations

Uridine adenosine tetraphosphate and purinergic signaling in cardiovascular system: An update

Zhou

Matsumoto

Jankowski

et al. 2019

Pharmacological Research

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Uridine adenosine tetraphosphate (Up 4 A), biosynthesized by activation of vascular endothelial growth factor receptor (VEGFR) 2, was initially identified as a potent endothelium-derived vasoconstrictor in perfused rat kidney. Subsequently, the effect of Up 4 A on vascular tone regulation was intensively investigated in arteries isolated from different vascular beds in rodents including rat pulmonary arteries, aortas, mesenteric and renal arteries as well as mouse aortas, in which Up 4 A produces vascular contraction. In contrast, Up 4 A produces vascular relaxation in porcine coronary small arteries and rat aortas. Intravenous infusion of Up 4 A into conscious rats or mice decreases blood pressure, and intravenous bolus injection of Up 4 A into anesthetized mice increases coronary blood flow, indicating an overall vasodilator influence in vivo. Although Up 4 A *

show abstract

Section: Diabetesmentioning

confidence: 81%

Section: Diabetesmentioning

confidence: 84%

Section: Matsumoto Et Al Found a Similar Contraction Pattern Inducedmentioning

confidence: 92%

Section: Matsumoto Et Al Found a Similar Contraction Pattern Inducedmentioning

confidence: 95%

Section: Matsumoto Et Al Found a Similar Contraction Pattern Inducedmentioning

confidence: 99%

See 3 more Smart Citations

Uridine adenosine tetraphosphate and purinergic signaling in cardiovascular system: An update

Zhou

Matsumoto

Jankowski

et al. 2019

Pharmacological Research

Self Cite

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Decreased contraction induced by endothelium-derived contracting factor in prolonged treatment of rat renal artery with endoplasmic reticulum stress inducer

Ando

Matsumoto

Taguchi

et al. 2018

Naunyn-Schmiedeberg's Arch Pharmacol

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Recent evidence suggests that endoplasmic reticulum (ER) stress is involved in the regulation of various physiological functions, including those of the vascular system. However, the relationship between ER stress and vascular function is poorly understood. The endothelial cells control the vascular tone by releasing endothelium-derived relaxing factors and contracting factors (EDCFs). We hypothesized that tunicamycin, an inducer of ER stress, modifies endothelium-dependent contraction and prostaglandins (PGs), a major class of EDCFs, induced contractions in the rat renal artery in rats. An organ-culture technique was used to purely investigate the effects of ER stress on the vascular tissue. We observed that tunicamycin treatment (20 μg/mL for 23 ± 1 h) did not affect acetylcholine (ACh)-induced relaxation and decreased EDCF-mediated contractions under nitric oxide synthase (NOS) inhibition induced by ACh, ATP, or A23187 (a calcium ionophore) in the renal arteries. Under NOS inhibition, U46619 (a thromboxane A mimetic)- and beraprost (a prostacyclin analog)-induced contractions were also decreased in the renal arteries of the tunicamycin-treated group (vs. vehicle), while PGE- and PGF-induced contractions were similar between the groups. Tunicamycin treatment slightly enhanced the contractions induced by phenylephrine, an α adrenoceptor ligand. Isotonic high-K-induced contractions were similar between the vehicle- and tunicamycin-treated groups. Another ER stress inducer, thapsigargin (4 μmol/L for 23 ± 1 h), also caused substantial reduction of ACh-induced EDCF-mediated contraction (vs. vehicle-treated group). In the cultured renal arteries, tunicamycin and thapsigargin increased the expression of binding immunoglobulin protein (BiP), an ER stress marker. In conclusion, ER stress induction directly affects renal arterial function, especially in reducing EDCF-mediated contractions.

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Amplification of the COX/TXS/TP receptor pathway enhances uridine diphosphate-induced contraction by advanced glycation end products in rat carotid arteries

Matsumoto

Kojima

Takayanagi

et al. 2019

Pflugers Arch - Eur J Physiol

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Alteration of Vascular Responsiveness to Uridine Adenosine Tetraphosphate in Aortas Isolated from Male Diabetic Otsuka Long-Evans Tokushima Fatty Rats: The Involvement of Prostanoids

Cited by 15 publications

References 68 publications

Uridine adenosine tetraphosphate and purinergic signaling in cardiovascular system: An update

Uridine adenosine tetraphosphate and purinergic signaling in cardiovascular system: An update

Decreased contraction induced by endothelium-derived contracting factor in prolonged treatment of rat renal artery with endoplasmic reticulum stress inducer

Amplification of the COX/TXS/TP receptor pathway enhances uridine diphosphate-induced contraction by advanced glycation end products in rat carotid arteries

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