Alteration profile of executive functions in multiple sclerosis

García, Marta Cerezo; Plasencia, Pilar Martín; Benito, Yolanda

doi:10.1111/ane.12345

Cited by 37 publications

(11 citation statements)

References 31 publications

(56 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, our results confirm the primary engagement of verbal memory and executive functions in very mild levels of clinical disability in accordance with previous studies [7, 29, 30]. Cerezo García and colleagues [29], in a small cohort of patients, found that 24% of very mild RRMS patients had memory deficits and 80% showed information processing speed and executive function impairment, especially in the maintenance of nonautomatic strategies and conceptual/categorization tasks, usually attributed to prefrontal regions.…”

Section: Discussionsupporting

confidence: 93%

“…Cerezo García and colleagues [29], in a small cohort of patients, found that 24% of very mild RRMS patients had memory deficits and 80% showed information processing speed and executive function impairment, especially in the maintenance of nonautomatic strategies and conceptual/categorization tasks, usually attributed to prefrontal regions. Roca and colleagues [30] showed that MS patients with low physical disability presented a fronto-subcortical pattern with impairment in memory, decision-making, working memory, and planning, as well as in goal-oriented behavior.…”

Section: Discussionmentioning

confidence: 99%

“…Ruano and colleagues [7], in a large Italian multicenter study, show a significant presence of CI since the earlier stages of MS in patients with RRMS and CIS with a more frequent involvement of information processing speed and executive function compared with other cognitive domains. In particular, these studies [7, 29, 30] used a specific executive battery consisting of sensitive tests to detect prefrontal cortex dysfunction.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Cognitive Impairment in Relapsing-Remitting Multiple Sclerosis Patients with Very Mild Clinical Disability

Migliore

Ghazaryan

Simonelli

et al. 2017

Behavioural Neurology

View full text Add to dashboard Cite

Cognitive dysfunction affects 40–65% of multiple sclerosis (MS) patients and can occur in the early stages of the disease. This study aimed to explore cognitive functions by means of the Italian version of the minimal assessment of cognitive function in MS (MACFIMS) in relapsing-remitting MS (RRMS) patients with very mild clinical disability to identify the primarily involved cognitive functions. Ninety-two consecutive RRMS patients with Expanded Disability Status Scale (EDSS) scores ≤ 2.5 and forty-two healthy controls (HC) were investigated. Our results show that 51.1% of MS patients have cognitive dysfunction compared to HC. An impairment of verbal and visual memory, working memory, and executive functions was found in the RRMS group. After subgrouping RRMS by EDSS, group 1 (EDSS ≤ 1.5) showed involvement of verbal memory and executive functions; moreover, group 2 (2 ≤ EDSS ≤ 2.5) patients were also impaired in information processing speed and visual memory. Our results show that utilizing a comprehensive neuropsychological assessment, approximately half of MS patients with very mild physical disability exhibit cognitive impairment with a primary involvement of prefrontal cognitive functions. Detecting impairment of executive functions at an early clinical stage of disease could be useful to promptly enroll MS patients in targeted rehabilitation.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Cognitive Impairment in Relapsing-Remitting Multiple Sclerosis Patients with Very Mild Clinical Disability

Migliore

Ghazaryan

Simonelli

et al. 2017

Behavioural Neurology

View full text Add to dashboard Cite

show abstract

“…It can occur at any point during the disease’s progression, and it most often affects memory, attention, and processing speed (Shatil, Metzer, Horvitz, & Miller, 2010). Persons with MS have also been found to perform poorly on executive function tests (Arnett, et al, 1997; Drew, Tippett, Starkey, & Isler, 2008; Garcia, Plasencia, & Benito, 2015) Halper, et al also proposed that the ability to grasp complex concepts, plan, and adhere to a schedule can be affected (Halper, et al, 2003). Such impairments can seriously impact daily functioning, including one’s employment (Rao et al, 1991).…”

Section: Introductionmentioning

confidence: 99%

An initial investigation of the reliability and validity of the Compensatory Cognitive Strategies Scale

Becker

Stuifbergen

Henneghan

et al. 2017

Neuropsychological Rehabilitation

View full text Add to dashboard Cite

Although many cognitive performance tests and self-reported cognitive concerns scales have been used to evaluate cognitive functioning, fewer measures assess the use of compensatory cognitive strategies for daily activities among those experiencing mild levels of cognitive impairment. The Compensatory Cognitive Strategies Scale was developed to measure frequency of self-reported cognitive strategies to decrease distractions, organize and sequence activities, and to utilize newly available computer aids to assist memory among those with multiple sclerosis (MS). Cronbach’s alpha, a measure of internal consistency reliability, was .89 and .90 in two different samples. Concurrent validity was supported by the total score’s moderate correlation with the MMQ-Strategy Scale (rs = .67) and by a statistically significant increase in total scores for those who had participated in an intervention designed to improve their cognitive abilities. Correlations were stronger with another strategy measure than with measures of other constructs such as health promoting behaviors, thus supporting the scales convergent versus divergent validity. These initial findings suggest that the Compensatory Cognitive Strategies Scale may be useful to both researchers and clinicians working to build compensatory strategies for day-to-day functioning among those with mild cognitive impairment.

show abstract

“…Information processing in particular is the cognitive domain most widely affected by MS and is notably the first deficit to emerge [17–19]. MS patients with progressive disease course, especially secondary progressive, can also experience a range of cognitive deficits and associated disability [20]. MS has been associated with delayed recall performance and lower acquisition of verbal memory [21] and episodic short-term memory [22].…”

Section: Introductionmentioning

confidence: 99%

The Relationship between Psychosocial Factors and Cognition in Multiple Sclerosis

Alosaimi

AlMulhem

Moscovici

et al. 2017

Behavioural Neurology

View full text Add to dashboard Cite

Introduction Multiple sclerosis (MS) is a common disorder in some regions of the world, with over 2.3 million people diagnosed worldwide. Cognitive impairment is one of the earliest symptoms to present in the course of the disease and can cause significant morbidity. We proposed a study to explore the psychosocial predictors of cognitive impairment in MS patients in Saudi Arabia, a previously unexplored patient population. Methods Demographic data, depression scale (PHQ9), symptom burden (PHQ15), anxiety (GAD7), disease duration, and Montreal Cognitive Assessment (MOCA) scores were collected from 195 patients in a neurology clinic in Ryiadh, Saudi Arabia. Univariate and multiple regression analyses were conducted to identify variables that are significantly associated with cognitive impairment. Results Variables that were identified to be significantly associated with cognition, p < 0.05, were education level, disease duration, and family history. Discussion Both education level and disease duration were variables identified in previous studies. We showed family history to be a significant variable, and no association was found with depression or anxiety, which is unique to our study population. Conclusions We identified several psychosocial predictors that are associated with cognition in our patient population. It was also noted that a difference exists between patient populations, highlighting the need for further studies in specific geographical regions.

show abstract

Alteration profile of executive functions in multiple sclerosis

Abstract: Cognitive flexibility, inhibition and abstraction ability were the three components of EF most deficient. The patients with the worst performance were those with progressive forms and a high EDSS.

Cited by 37 publications

References 31 publications

Cognitive Impairment in Relapsing-Remitting Multiple Sclerosis Patients with Very Mild Clinical Disability

Cognitive Impairment in Relapsing-Remitting Multiple Sclerosis Patients with Very Mild Clinical Disability

An initial investigation of the reliability and validity of the Compensatory Cognitive Strategies Scale

The Relationship between Psychosocial Factors and Cognition in Multiple Sclerosis

Contact Info

Product

Resources

About