Alteration to the Skin Ceramide Profile Following Broad-Spectrum UV Exposure

Barresi, Rebecca; Dumbuya, Hawasatu; Liao, I-Chien; Chen, Ying; Yan, Xin; Wangari-Olivero, Janet; Baalbaki, Nada; Lynch, Stephen; Brieva, Patricia; Wang, Miao; Zheng, Qian; Bouez, Charbel

doi:10.36849/jdd.6331

Cited by 6 publications

(7 citation statements)

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“…This suggests that ceramides play a significant role in repairing UV‐induced skin damage. As our previous study shows, topical application of ceramide‐containing suncare products help maintain SC essential ceramide subclasses and proper ceramide chain length in ex vivo model 3 …”

Section: Discussionmentioning

confidence: 73%

“…Skin barrier damage may be indicated by an increase in TEWL, a decrease in water content, and an increase in erythema index. Furthermore, our previous research has shown that exposure to high levels of UV can lead to a reduction in skin barrier proteins and ceramides, which covalently bind to corneocytes, resulting in damage to the skin's brick‐and‐mortar structure 3,4 …”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, our previous research has shown that exposure to high levels of UV can lead to a reduction in skin barrier proteins and ceramides, which covalently bind to corneocytes, resulting in damage to the skin's brick-and-mortar structure. 3,4 Sunscreen is currently one of the best ways to protect against UV radiation. In the past, research has mainly about sunscreen focused on maximizing UV absorption, prevent skin from photodamage or skin cancer, and developing sunscreens that are safe for coral reefs.…”

mentioning

confidence: 99%

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Efficacy of ceramide‐containing sunscreen on skin barrier

Cao,

Zhang,

et al. 2023

J of Cosmetic Dermatology

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BackgroundUV rays not only cause oxidative damage to the skin, but also damage its barrier function. The use of sunscreen is crucial in preventing skin from UV radiation, but it may have an impact on the function of the skin barrier. While much research has focused on the protective effects of sunscreen against UV oxidative damage, little is known about the impact of daily sunscreen use on the skin barrier.ObjectiveThis study mainly investigated the changes in skin barrier function of volunteers (including those with sensitive skin) before and after using a ceramide‐containing sunscreen.MethodsA total of 60 volunteers used SPF30 sunscreen containing ceramide every morning. Using non‐invasive methods to detect skin barrier changes in TEWL, hydration, facial redness based on VISIA‐CR image, and Erythema index (EI) value after 4 weeks of using ceramide‐containing sunscreen. Adverse reactions were also assessed.ResultsAfter 4 weeks of using ceramide‐containing sunscreen, significant reductions were observed in skin redness with both an 11.89% decrease in a* value and a 5.68% decrease in skin EI, while there was also a significant decrease in transepidermal water loss (TEWL) with a reduction of 22.96%, and a significant increase in skin hydration with a 21.96% increase in the moisture content of the stratum corneum. No adverse events occurred during the entire testing process.ConclusionDaily application of ceramide‐containing sunscreen can increase skin hydration while enhancing the function of the skin barrier.

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Section: Discussionmentioning

confidence: 73%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Efficacy of ceramide‐containing sunscreen on skin barrier

Cao,

Zhang,

et al. 2023

J of Cosmetic Dermatology

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“…ultraviolet radiation (UVR), ozone], ageing and inflammatory disease (e.g. atopic dermatitis, psoriasis, xerosis, ichthyosis) [14][15][16][17]. Studies into the barrier function and stratum corneum lipid composition of ethnic or pigmented skin are so far inconclusive, with more work needed to identify any potential differences [18,19] Sphingomyelin, a sphingolipid providing ceramides via a hydrolysis pathway, can also contribute to the maintenance of the skin barrier via phosphorylation of the signal transducer and activator of transcription 3 (STAT3) [29].…”

Section: Key Pointsmentioning

confidence: 99%

“…ultraviolet radiation (UVR), ozone], ageing and inflammatory disease (e.g. atopic dermatitis, psoriasis, xerosis, ichthyosis) [14–17]. Studies into the barrier function and stratum corneum lipid composition of ethnic or pigmented skin are so far inconclusive, with more work needed to identify any potential differences [18,19].…”

Section: Lipids Have Different Roles Throughout the Skinmentioning

confidence: 99%

Current insights into skin lipids and their roles in cutaneous health and disease

Nicolaou

Kendall²

2022

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of reviewThe unique and complex array of cutaneous lipids include essential components of the skin structure and signalling molecules mediating homeostasis and inflammation. Understanding skin lipid biology and metabolism can support our comprehension of health and disease, including systemic conditions with cutaneous involvement.Recent findingsLipids found on the skin surface, produced by both the host and resident microbes, maintain and regulate the skin microbiome and the epidermal barrier, whilst altered contributions from either source can be detrimental to skin health. The unique lipid composition of the epidermal barrier is essential for its function, and recent studies have expanded our understanding of epidermal ceramide production. This has been supported by improved models available for skin research, including organotypic skin models enabling in-vitro production of complex acylceramides for the first time, and model systems facilitating in-silico exploration of the lipid profile changes observed in clinical samples. Studies have revealed further involvement of lipid mediators such as eicosanoids in cutaneous inflammation, as well as immune regulation in both healthy and diseased skin.SummarySkin lipids offer exciting opportunities as therapeutic targets for many conditions, whether through topical interventions or nutritional supplementation.

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