Alterations and clinical relevance of gut microbiota in patients with <scp>Peutz–Jeghers</scp> syndrome: A prospective study

Wang, Yuxin; Huabing, Huang; Yan, Dong; Li, Zhao‐Shen; Liu, Feng; Du, Yiqi

doi:10.1111/1751-2980.13175

Cited by 3 publications

(1 citation statement)

References 53 publications

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“…Consistent with our results, Wang et al indicated that genus Bacteroides were enriched, while the genus Blautia were decreased in patients with PJS. Besides, Du et al investigated the feature of gut microbiota in 32 PJS patients and analyzed the relationship between gut microbiota and the growth of polyps [ 31 ]. The results suggested that the structure of the gut microbiota differed between healthy controls and PJS patients, while the richness was comparable.…”

Section: Discussionmentioning

confidence: 99%

Changes of gut microbiota and short chain fatty acids in patients with Peutz–Jeghers syndrome

Zhou,

Tang,

Xie

et al. 2023

BMC Microbiol

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Peutz–Jeghers Syndromeis a rare autosomal dominant genetic disease characterized by gastrointestinal hamartomatous polyps and skin and mucous membrane pigmentation. The pathogenesis of PJS remains unclear; however, it may be associated with mutations in the STK11 gene, and there is currently no effective treatment available. The gut microbiota plays an important role in maintaining intestinal homeostasis in the human body, and an increasing number of studies have reported a relationship between gut microbiota and human health and disease. However, relatively few studies have been conducted on the gut microbiota characteristics of patients with PJS. In this study, we analyzed the characteristics of the gut microbiota of 79 patients with PJS using 16 S sequencing and measured the levels of short-chain fatty acids in the intestines. The results showed dysbiosis in the gut microbiota of patients with PJS, and decreased synthesis of short-chain fatty acids. Bacteroides was positively correlated with maximum polyp length, while Agathobacter was negatively correlated with age of onset. In addition, acetic acid, propionic acid, and butyric acid were positively correlated with the age of onset but negatively correlated with the number of polyps. Furthermore, the butyric acid level was negatively correlated with the frequency of endoscopic surgeries. In contrast, we compared the gut microbiota of STK11-positive and STK11-negative patients with PJS for the first time, but 16 S sequencing analysis revealed no significant differences. Finally, we established a random forest prediction model based on the gut microbiota characteristics of patients to provide a basis for the targeted diagnosis and treatment of PJS in the future.

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Section: Discussionmentioning

confidence: 99%

Changes of gut microbiota and short chain fatty acids in patients with Peutz–Jeghers syndrome

Zhou,

Tang,

Xie

et al. 2023

BMC Microbiol

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Progress report: Peutz–Jeghers syndrome

Jelsig,

Karstensen,

Overeem Hansen

2024

Familial Cancer

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Global research landscape of Peutz-Jeghers syndrome and successful endoscopic management of intestinal intussusception in patients with recurrent laparotomies

Sun,

Wang,

Guo

et al. 2024

World J Gastrointest Surg

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BACKGROUND Peutz-Jeghers syndrome (PJS) has brought significant physical, psychological and economic burdens on the patients and their families due to its early onset, diagnostic and therapeutic challenges and increased recurrence risk. AIM To explore the current research status and emerging hotspots of PJS. METHODS Studies on PJS published during 1994-2023 were gathered based on Web of Science Core Collection. Additionally, a case of PJS-induced intestinal intussusception, successfully treated with endoscopic methods despite three laparotomies, was highlighted. Comprehensive bibliometric and visual analysis were conducted with VOSviewer, R and CiteSpace. RESULTS Altogether 1760 studies were identified, indicating a steady increase in the publication number. The United States had the highest influence, whereas the University of Helsinki emerged as the leading institution, and Aaltonen LA from the University of Helsinki was the most prolific author. Cancer Research, Oncogene and Endoscopy were the top three journals based on H-index. Keyword burst direction analysis revealed that "cancer risk", "management", "surveillance" and "familial pancreatic cancer" were the potential hotspots for investigation. Additionally, "early detection", "capsule endoscopy", "clinical management", "double-balloon endoscopy", "familial pancreatic cancer" and "molecular genetic basis" were identified as the key clusters of co-cited references. Endoscopic polypectomy remained effective on resolving intestinal intussusception in patients who underwent three previous laparotomies. CONCLUSION In the last three decades, global publications related to PJS show a steadily increasing trend in number. Endoscopic management is currently a research hotspot.

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Alterations and clinical relevance of gut microbiota in patients with Peutz–Jeghers syndrome: A prospective study

Cited by 3 publications

References 53 publications

Changes of gut microbiota and short chain fatty acids in patients with Peutz–Jeghers syndrome

Changes of gut microbiota and short chain fatty acids in patients with Peutz–Jeghers syndrome

Progress report: Peutz–Jeghers syndrome

Global research landscape of Peutz-Jeghers syndrome and successful endoscopic management of intestinal intussusception in patients with recurrent laparotomies

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