Alterations in anterior chamber depth in primary open‐angle glaucoma patients during latanoprost therapy

Abstract

ABSTRACT.Purpose: The aim of this study was to evaluate changes in the anterior chamber depth (ACD) in primary open-angle glaucoma (POAG) patients during latanoprost therapy. Methods: We carried out a prospective study in which we enrolled 66 newly diagnosed POAG patients treated with latanoprost 0.005% (group 1) and 50 ocular hypertensive and ⁄ or glaucoma suspect cases who were given no therapy (group 2 [control]). Measurements of the ACD were performed by A-scan ultrasonography before and after cycloplegia at baseline and at 3 months of latanoprost therapy. Differences in ACD and their correlations with the ocular hypotensive effect of the agent as well as the clinical significance of changes in ACD were analysed using Student's t-test and Pearson's correlation coefficient. Statistical significance was set at p < 0.05. Results: Mean baseline ACD was 3.13 ± 0.35 mm (range 2.45-3.84 mm) in group 1 and 3.14 ± 0.36 mm (range 2.54-3.80 mm) in group 2 (p = 0.89). At 1 hour after instillation of cyclopentolate 1%, mean ACD in groups 1 and 2 was 3.18 ± 0.38 mm (range 2.45-3.92 mm) and 3.19 ± 0.37 mm (range 2.56-3.91 mm), respectively (p = 0.91). After 3 months of treatment, mean ACD in group 1 both without (3.05 ± 0.36 mm, range 2.14-3.76 mm) and with (3.09 ± 0.4 mm, range 2.20-3.96 mm) cycloplegia was significantly reduced compared with baseline values (p < 0.001 for both). However, there was no significant difference between mean ACD at baseline and that at month 3 in group 2. No correlation was demonstrated between the changes in ACD and the ocular hypotensive effect of latanoprost (p = 0.96, r = ) 0.006). There were no changes in refractive status or visual acuity. Conclusions: The overall results seem to suggest that latanoprost decreases mean ACD in patients with POAG. The clinical significance of this effect is uncertain.

Comparison of Refractive Status and Anterior Segment Parameters of Juvenile Open-Angle Glaucoma and Normal Subjects

“…We measured these parameters before antiglaucoma treatment and excluded patients with previous anti-glaucoma treatment because these agents may affect the structure of the anterior segment. 17,18…”

Alterations in anterior chamber depth in primary open angle glaucoma patients during latanoprost therapy – Authors' reply

“…The main purpose of our study was to investigate the alterations in anterior chamber depth (ACD) during latanoprost 0.005% therapy and whether these alterations were influenced by the effect of cyclopentolate. In our study, latanoprost was found to have a decreasing effect on ACD in eyes both with and without cycloplegia (Cankaya et al. 2011).…”

“…We thank Drs Gutierrez‐Ortiz C and Teus M (2011) for their interest in our article (Cankaya et al. 2011) and note their concern regarding the possible misinterpretation of our findings.…”

Alterations in anterior chamber depth in primary open‐angle glaucoma patients during latanoprost therapy

“…Cankaya et al. (2011) speculate that their finding that cycloplegia deepened the anterior chamber to the same extent after latanoprost therapy than in virgin eyes rules out that latanoprost‐induced weakening in the zonular fibres may be present.…”

“…We have read, with interest, the paper recently published in Acta Ophthalmologica by Cankaya et al. (2011).…”