Alterations in brain sensitivity and barbiturate metabolism unrelated to aggression in socially deprived mice

Baumel, Irwin; DeFeo, John J.; Lal, Harbans

doi:10.1007/bf00412678

Cited by 22 publications

(14 citation statements)

References 10 publications

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“…These may involve the already reported heightened brain excitability during socioenvironmental deprivation (Baumel et al, 1970;Kimbrell, 1967;King et al, 1955;Valzelli, 1967Valzelli, , 1969Valzelli, , 1973. This is also suggested by the fact that isolated mice recover from barbiturate narcosis at a drug concentration which is still narcosis-maintaining in grouped animals (.…”

Section: Discussionmentioning

confidence: 77%

“…the direct activity of these drugs on nerve cells (Brazier, 1963), and their inactivation rate by hepatic microsomes (Noordhoek, 1968). Enhancement of the hepatic inactivation of barbiturates by social deprivation has been demonstrated (a) in vitro by direct measurement of microsomal enzyme activity in hepatic tissue from isolated mice (Baumel et al, 1969); (b) in vivo by a faster decline of hexobarbital content in the body of isolated mice (Baumel et al, 1970), and (c) by increased microsomal protein synthesis and hepatic microsomal metabolism of 2-14C pentobarbital in isolated mice (Essman et al, 1972).…”

Section: Discussionmentioning

confidence: 99%

“…This is also suggested by the fact that isolated mice recover from barbiturate narcosis at a drug concentration which is still narcosis-maintaining in grouped animals (. Baumel et al, 1970).…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that isolated-aggressive mice are significantly less sensitive to barbiturate sedation (Balazs and Dairman, 1967 ;Baumel et aL, 1969Baumel et aL, , 1970Consolo et al, 1965b) and to chlorpromazine potentiation of barbiturate sleeping time (Consolo et al, 1965b). It has also been thought that aggressive ness induced by prolonged socioenvironmental deprivation or isolation results from overall heightened neuroexcitability.…”

Section: Introductionmentioning

confidence: 99%

“…sensitivity to CNS depressants, since female mice, which do not become aggressive after prolonged isolation ( Valzelli, 1967( Valzelli, , 1969, still show increased resistance to hexobarbital narcosis (Baumel et al, 1970).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Alcohol, Prolonged Isolation and Barbiturate Sedation in Two Strains of Mice

Valzelli¹,

Bernasconi²

1978

Neuropsychobiology

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Mice subjected to prolonged socioenvironmental deprivation gradually develop hyperirritability and hyperreactivity to physical stimuli. This heightened neuroexcitability may or may not debouch into aggressiveness according to strain and sex of the animals, and it is accompanied by a reduced sensitivity to CNS depressants. Socioenvironmental deprivation or isolation is shown to decrease the sensitivity either to pentobarbital or to ethanol potentiation of pentobarbital sleeping time in male mice from two different strains.

show abstract

Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Alcohol, Prolonged Isolation and Barbiturate Sedation in Two Strains of Mice

Valzelli¹,

Bernasconi²

1978

Neuropsychobiology

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Some characteristics of the aggressive behavior of mice after prolonged Isolation: Intraspecific and interspecific aspects

Poshivalov¹

1981

Aggr. Behav.

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Experiments on mice have demonstrated changes in the relationships, interdependence and sequence of behavioral items following prolonged isolation. It was found that aggression in isolates was stereotyped and hardly amenable to the control not only by intraspecific but also by interspecific factors. Isolated mice, in contrast to the group‐reared animals, spontaneously attacked adult rats. This finding was interpreted as being due to a disruption of behavioral plasticity under circumstances of prolonged isolation from conspecifics.

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Behavioral and adrenocortical reactivity in female mice following individual or group housing

Benton

Brain

1981

Developmental Psychobiology

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Female "TO" strain mice were individually or group-housed for different durations (7-196 days). Behavioral reactivity was assessed for 3 days in an open field and an emergence test. Plasma samples were later collected after 5 min exposure to ethyl ether vapor; these generated "stress" corticosterone values. "Basal" corticosterone titers were obtained from similar untested and unanesthetized categories of mice. "Ether-stress" values were obtained from a limited number of mice subjected to ether anesthesia but no behavioral testing. Neither the basal nor the stress adrenocortical activities of the 2 housing categories differed. Open-field ambulation increased with longer durations of isolation, whereas for grouped mice it remained approximately constant. Individually housed mice had significantly lower defecation scores and longer emergence times than group-housed mice. In sum, little support was provided for the view that isolation is stressful.

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Alterations in brain sensitivity and barbiturate metabolism unrelated to aggression in socially deprived mice

Cited by 22 publications

References 10 publications

Alcohol, Prolonged Isolation and Barbiturate Sedation in Two Strains of Mice

Alcohol, Prolonged Isolation and Barbiturate Sedation in Two Strains of Mice

Some characteristics of the aggressive behavior of mice after prolonged Isolation: Intraspecific and interspecific aspects

Behavioral and adrenocortical reactivity in female mice following individual or group housing

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