Alterations in cerebral glucose metabolism as measured by 18F-fluorodeoxyglucose-PET in patients with persistent postconcussion syndrome

Abstract

Supplemental Digital Content is available in the text.

Aging and Cerebral Glucose Metabolism: 18F-FDG-PET/CT Reveals Distinct Global and Regional Metabolic Changes in Healthy Patients

“…All subjects underwent whole-body 18 F-FDG-PET/CT imaging 180 min following the administration of a 4.0 MBq/kg dose of FDG. The acquisition time was 3.5 min/bed.…”

“…The global average standardized uptake value mean (Avg SUVmean) was measured via mapping ROS of the entire brain across the supratentorial structures and cerebellum. To analyze FDG regional uptake in the brain, quantitative regional analysis was conducted using MIMneuro version 7.1.5 (MIM Software, Inc., Cleveland, OH, USA) through validated methods [18,19]. MIMneuro registers each brain to a standard template, allowing for increased accuracy in quantitative comparisons.…”

“…Monitoring changes in AG via positron emission tomography (PET) have shown a drastic reduction in glucose metabolism, leading to the use of AG has a biomarker for normal neurological aging [7][8][9][10]. 18 F-Fluorodeoxyglucose (FDG) positron emission tomography (PET) has been established as a leading tool in measuring changes suspected in both normal and pathological aging; 18 F-FDG-PET/CT enables the monitoring of glucose metabolism, cerebral blood flow, and oxygen consumption [11,12]. While FDG-PET has traditionally been employed for metabolic assessment, it is worth noting that alternative tracers, such as radiowater, are also utilized in measuring blood flow and oxygen consumption [13].…”

“…This allows FDG to be utilized as a tracker of functional activity in both physiological and pathological aging [12,[14][15][16]. Furthermore, 18 F-FDG-PET/CThas shown to be comparatively more sensitive in monitoring patients with moderate cognitive impairment and their progression into dementia and other neurological degenerative diseases relative to other imaging methods, including single-photon emission computed tomography (SPECT) and structural magnetic resonance imaging (MRI) [11,16]. In this study, we evaluated global and regional neurological glucose metabolism in a group of healthy individuals.…”

Ketone Supplementation: Meeting the Needs of the Brain in an Energy Crisis

“…A transient increase in cerebral glucose uptake termed “hyperglycolysis” is observed within 8 days following TBI in humans but is followed by a prolonged period of glucose hypometabolism ( 13 ). This magnitude and period of metabolic depression is injury severity-dependent, can persist for days to weeks, and is associated with behavioral deficits and impaired cognitive and physical function in animals and humans ( 14 , 15 ).…”