Alterations in cochlear function during induced acute hyperinsulinemia in an animal model

Angeli, Roberto Dihl; Lavinsky, Luíz; Dolganov, Alexandre

doi:10.1016/s1808-8694(15)30530-9

Cited by 10 publications

(10 citation statements)

References 15 publications

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“…Our original hypothesis that SF OAE amplitudes would increase during hyperglycemia was based on the fact that glucose is the energy for the cochlea, and that when the cochlea is deprived of its energy source, there should be a decrease in the EP, which would result in a reduced OAE amplitude measurement. Wing (1959) and Koide (1958) and more recently Angelie et al (2009) showed that hypoglycemia reduces the endocochlear potential (EP) and cochlear microphonic amplitudes. A reduction in cochlear microphonics during hypoglycemia may be caused by the lack of available energy required for maintaining the active transport of sodium and potassium ions into and out of the endolymph in the cochlea.…”

Section: Discussionmentioning

confidence: 99%

Influence of acute hyperglycemia on otoacoustic emissions and the medial olivocochlear reflex

Jacobs

Konrad-Martin

McMillan

et al. 2012

The Journal of the Acoustical Society of America

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Stimulus-frequency (SF) otoacoustic emission (OAE) amplitude and the amplitude of medial olivocochlear (MOC) inhibition of SF OAEs for ipsilateral, contralateral and bilateral MOC reflex elicitors were recorded in six subjects with type 2 diabetes during a glucose tolerance test (GTT). Five of the six subjects were tested twice for a total of 11 trials and three subjects were tested in a control experiment. During the GTT experiment, the subjects' blood glucose was elevated from a euglycemic level below 150 mg/dL to a hyperglycemic level above 160 mg/dL following the consumption of a bolus of 80 g of sugar. A subset of three subjects were tested in a control experiment during which SF OAE and MOC reflex measurements were made while blood sugar levels remained constant within the euglycemic region. Mean SF OAE amplitudes were elevated following glucose consumption. A statistically significant increase in MOC inhibition amplitude was observed during elevated sugar levels for the 11 GTT trials. Maximum inhibition occurred about an hour after glucose consumption when blood glucose levels peaked. Results indicate that acute hyperglycemia influences efferent control of the cochlea in people with type 2 diabetes.

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Section: Discussionmentioning

confidence: 99%

Influence of acute hyperglycemia on otoacoustic emissions and the medial olivocochlear reflex

Jacobs

Konrad-Martin

McMillan

et al. 2012

The Journal of the Acoustical Society of America

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“…8,9 Furthermore, the labyrinth is very sensitive to small changes in plasma insulin levels, due to the large number of insulin receptors present in the endolymphatic sac. 11 Based on these suggestive signs (i.e., that glucose metabolism may be associated to clinical pictures of benign paroxysmal positional vertigo), this study found some relations, such as: the hyperinsulinemic patient has a RR 4.6 times higher for BPPV recurrence, compared with the general population ---a statistically significant finding.…”

Section: Discussionmentioning

confidence: 99%

Hyperinsulinemia and hyperglycemia: risk factors for recurrence of benign paroxysmal positional vertigo

Webster

Sens

Salmito

et al. 2015

Brazilian Journal of Otorhinolaryngology

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“…A tone burst stimulus was delivered at the external acoustic meatus in frequencies ranging between 4200–6820 Hz and intensity of 82 SPL, according to the protocol of electrophysiological threshold recording of normal cochlear potentials in sheep 5 .…”

Section: Methodsmentioning

confidence: 99%

Avaliação dos potenciais evocados cocleares após lesão do utrículo por eletrocauterização

Maia¹,

Dolganov²,

Lavinsky³

2012

Braz. j. otorhinolaryngol.

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Ut riculostomy is a new surgical alternative for Ménière's disease. The basis of this procedure is that the outcome of an electrocautery-induced utricular trauma does not affect cochlear function. However, a demonstration of the hypothesis that this approach to the utricle would preserve hearing is still pending.Objective: To determine whether any changes would occur in the electrical potentials evoked in the cochlea and auditory nerve before, during, and 1 month after a surgical procedure in the utricule in an animal model. Materials and Methods:An experimental study. Eight sheep underwent electrocautery-induced utricular trauma, and their cochlear function was assessed by electrocochleography -recording of electrical evoked potentials, in the preoperative, immediate postoperative and medium-term postoperative periods. The results were analyzed statistically.Results: There were no statistically significant variations in amplitude (p = 0.099) and latency (p = 0.591) before and 1 month after the surgical procedure. There was a statistically significant change in the summation of the potential/action potential area ratio (p = 0.0122), a calculated loss of 11.8 dB. Conclusion:The intervention performed in this study enabled us to conclude that, taking into account the impaired electrophysiological responses observed during and 1 month after the surgical procedure, hearing was preserved in the operated sheep. ORIGINAL ARTICLEBraz J Otorhinolaryngol. 2012;78(2):52-8.

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Alterations in cochlear function during induced acute hyperinsulinemia in an animal model

Cited by 10 publications

References 15 publications

Influence of acute hyperglycemia on otoacoustic emissions and the medial olivocochlear reflex

Influence of acute hyperglycemia on otoacoustic emissions and the medial olivocochlear reflex

Hyperinsulinemia and hyperglycemia: risk factors for recurrence of benign paroxysmal positional vertigo

Avaliação dos potenciais evocados cocleares após lesão do utrículo por eletrocauterização

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