Alterations in cochlear function during induced acute hyperinsulinemia in an animal model

Angeli, Roberto Dihl; Lavinsky, Luíz; Dolganov, Alexandre

doi:10.1590/s1808-86942009000500024

Cited by 5 publications

(4 citation statements)

References 13 publications

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“…Changes in glucose metabolism have been associated with a high prevalence of inner ear disorders, hence with BPPV occurrence and recurrence [ 14 , 49 , 50 ]. These metabolic disorders can act as a principal etiologic factor in vestibular dysfunction, as well as an aggravating factor of a pre-existing vestibular disorder [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, these patients present mutations in the BETA2/NeuroD1 gene which is essential for the normal development of the sensory epithelia of the cochlea, utricle, saccule, and crista ampullaris [ 53 ]. On the other hand, hyperinsulinism may disrupt inner ear homeostasis and alter the ionic and metabolic characteristics of the stria vascularis, which is responsible for maintaining endocochlear potential through potassium secretion in the endolymphatic space [ 49 , 51 ]. The inner ear is also affected by hyperinsulinism due to a large number of the insulin receptors present in the endolymphatic sac [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

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Risk Factors for Recurrence of Benign Paroxysmal Positional Vertigo. A Clinical Review

Sfakianaki

Binos

Karkos

et al. 2021

JCM

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Benign paroxysmal positional vertigo (BPPV) is one of the most common peripheral vestibular dysfunctions encountered in clinical practice. Although the treatment of BPPV is relatively successful, many patients develop recurrence after treatment. Our purpose is to evaluate the mean recurrence rate and risk factors of BPPV after treatment. A review of the literature on the risk factors of BPPV recurrence was performed. A thorough search was conducted using electronic databases, namely Pubmed, CINAHL, Academic Search Complete and Scopus for studies published from 2000 to 2020. Thirty studies were included in this review with 13,358 participants. The recurrence rate of BPPV ranged from 13.7% to 48% for studies with follow-up <1 year, and from 13.3% to 65% for studies with follow-up ≥2 years. Pathophysiologic mechanisms and implication of each of the following risk factors in the recurrence of BPPV were described: advanced age, female gender, Meniere’s disease, trauma, osteopenia or osteoporosis, vitamin D deficiency, diabetes mellitus, hypertension, hyperlipidemia, cardiovascular disease, migraine, bilateral/multicanal BPPV, cervical osteoarthrosis and sleep disorders. Patients with hyperlipidemia and hypertension had the highest recurrence rates of BPPV, 67.80% and 55.89%, respectively, indicating that vascular comorbidities increase the risk of BPPV recurrence. In addition, more than half of patients (53.48%) with diabetes mellitus and BPPV experienced recurrence of BPPV. Knowledge and awareness of risk factors for recurrence of BPPV are essential for the assessment and long-term prognosis of patients. Identification of these relapse risk factors may enhance the ability of clinicians to accurately counsel patients regarding BPPV and associated comorbidities.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Risk Factors for Recurrence of Benign Paroxysmal Positional Vertigo. A Clinical Review

Sfakianaki

Binos

Karkos

et al. 2021

JCM

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“…Evidence suggests that the stria is the site of intense metabolic activity in the labyrinth. 35,36 A study revealed vestibular caloric stimulation (CS) inhibited noradrenergic (NA) neurons of the locus coeruleus (LC) in rats and hence speculating that LC-NA inhibition participates in the development of sensory mismatch during vertigo and motion sickness. 37 In diabetes mellitus, the observed changes are microangiopathy and peripheral neuropathy with consequent terminal blood flow problems and irregular supply of glucose.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study of Metabolic Disorders in Vertigo

Bepari¹,

Panditray²,

Palai³

et al. 2018

jemds

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BACKGROUND Vertigo is a common medical condition, affecting around 1.8% of young adults to more than 30% in the elderly. Metabolic disorders commonly related to labyrinthine dysfunctions are glucose metabolism changes (diabetes, reactive hypoglycaemia and hyperinsulinaemia), thyroid hormones and lipid metabolism disorders. The objective of this study is to compare the prevalence and association of metabolic disorders in vertigo cases to control under study. MATERIALS AND METHODS A case controlled study was done on patients presenting in ENT OPD, VIMSAR, Burla, with complaints of vertigo. 110 patients were chosen for the study between September 2015 and August 2017 and compared to age and gender matched controls (110). All patients and controls had the following blood investigations done: Fasting Blood Sugar (FBS), Oral Glucose Tolerance Test at 2 hrs. (OGTT2), thyroid profile (Free T3, Free T4, TSH) and Lipid Profile (Triglyceride (TG) and Low-Density Lipoprotein (LDL)). The metabolic disorders found were also compared to the ones found in the general population. The results were tabulated on excel sheets and statistical comparison and analysis was done with SPSS Version 16.0. Mann-Whitney U Test and chi-square test was applied for comparison. Statistical significance was set at p < 0.05. RESULTS The no. of vertigo patients with Type-2 diabetes mellitus were higher (1) in patients than controls. (2) Cases had more prevalence of thyroid disorders (3) than controls. (4) The incidence of abnormal lipid profile was higher in cases (35 cases with impaired TG, 27 cases with impaired LDL) than controls (17 each with impaired TG and LDL). The difference was significant in majority of parameters (FBS-p < 0.015; OGTT2-p < 0.316; T3-p < 0.000; T4-p < 0.002; TSH-p < 0.000; TG-p < 0.003; LDL-p < 0.814). The difference of diabetics and impaired glucose status in between cases of vertigo and controls are not statistically significant (p=0.770, ꭓ=0.086, chi-square test). The difference is highly significant in between cases and controls of thyroid disorder (p=0.002, ꭓ= 14.66) and lipid disorder (p= 0.000, ꭓ= 12.53, chi-square test). CONCLUSION Metabolic impairments in vertigo are substantial and hence cannot be ignored in management. FBS, TSH, T3, T4, TG and LDL values of cases were impaired more than controls and the difference was statistically significant for FBS, TSH, T3, T4, TSH and TG. Cases in our study had significantly higher prevalence of thyroid and lipid disorders than controls. This study could be applied in management of patients with chronic vertigo by dietary therapy or hormone replacement.

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“…A tone burst stimulus was delivered at the external acoustic meatus in frequencies ranging between 4200-6820 Hz and intensity of 82 SPL, according to the protocol of electrophysiological threshold recording of normal cochlear potentials in sheep 5 .…”

Section: Recording Of Auditory Evoked Potentialsmentioning

confidence: 99%

Avaliação dos potenciais evocados cocleares após lesão do utrículo por eletrocauterização

Maia¹,

Dolganov²,

Lavinsky³

2012

Braz. j. otorhinolaryngol.

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Ut riculostomy is a new surgical alternative for Ménière's disease. The basis of this procedure is that the outcome of an electrocautery-induced utricular trauma does not affect cochlear function. However, a demonstration of the hypothesis that this approach to the utricle would preserve hearing is still pending.Objective: To determine whether any changes would occur in the electrical potentials evoked in the cochlea and auditory nerve before, during, and 1 month after a surgical procedure in the utricule in an animal model. Materials and Methods:An experimental study. Eight sheep underwent electrocautery-induced utricular trauma, and their cochlear function was assessed by electrocochleography -recording of electrical evoked potentials, in the preoperative, immediate postoperative and medium-term postoperative periods. The results were analyzed statistically.Results: There were no statistically significant variations in amplitude (p = 0.099) and latency (p = 0.591) before and 1 month after the surgical procedure. There was a statistically significant change in the summation of the potential/action potential area ratio (p = 0.0122), a calculated loss of 11.8 dB. Conclusion:The intervention performed in this study enabled us to conclude that, taking into account the impaired electrophysiological responses observed during and 1 month after the surgical procedure, hearing was preserved in the operated sheep. ORIGINAL ARTICLEBraz J Otorhinolaryngol. 2012;78(2):52-8.

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Alterations in cochlear function during induced acute hyperinsulinemia in an animal model

Cited by 5 publications

References 13 publications

Risk Factors for Recurrence of Benign Paroxysmal Positional Vertigo. A Clinical Review

Risk Factors for Recurrence of Benign Paroxysmal Positional Vertigo. A Clinical Review

A Comparative Study of Metabolic Disorders in Vertigo

Avaliação dos potenciais evocados cocleares após lesão do utrículo por eletrocauterização

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