Search citation statements
Paper Sections
Citation Types
Year Published
Publication Types
Relationship
Authors
Journals
Objectives: The present study aimed to examine alterations in voxel-based degree centrality (DC) and functional connectivity (FC), and their relationship with cognitive impairments in individuals with myotonic dystrophy type 1 (DM1). Methods: Eighteen DM1 patients and eighteen healthy controls (HCs) participated in the study and were assessed using a comprehensive neuropsychological battery. Voxel-wise DC analysis was conducted to identify abnormal neural hubs in DM1 patients. Additionally, FC method was used to assess abnormalities in functional connections among these aberrant hubs. Correlational analyses were also used to identify and explore the relationship between altered DC and FC values and cognitive performance in DM1 patients. Results: DM1 patients exhibited reduced DC in the bilateral Rolandic operculum, left inferior frontal gyrus (triangular part), right angular gyrus, right median cingulate and paracingulate gyri, and right middle temporal gyrus. Conversely, increased DC was observed in the right fusiform gyrus, right hippocampus and left inferior temporal gyrus. FC analysis revealed that altered connectivity predominantly occurred between the right middle temporal gyrus, right angular gyrus and left inferior frontal gyrus (triangular part). Notably, the DCvaluein the right median cingulate was positively correlated withthe Trail Making Test Part A scores in DM1 patients (r = 0.616, p = 0.005, adjusted p <0.05). No significant correlations were discovered between FC values and neurocognitive performances. Conclusion: The study demonstrated that abnormalities in degree centrality and functional connectivity may become potential neuroimaging biomarkers for cognitive decline in DM1 patients.
Objectives: The present study aimed to examine alterations in voxel-based degree centrality (DC) and functional connectivity (FC), and their relationship with cognitive impairments in individuals with myotonic dystrophy type 1 (DM1). Methods: Eighteen DM1 patients and eighteen healthy controls (HCs) participated in the study and were assessed using a comprehensive neuropsychological battery. Voxel-wise DC analysis was conducted to identify abnormal neural hubs in DM1 patients. Additionally, FC method was used to assess abnormalities in functional connections among these aberrant hubs. Correlational analyses were also used to identify and explore the relationship between altered DC and FC values and cognitive performance in DM1 patients. Results: DM1 patients exhibited reduced DC in the bilateral Rolandic operculum, left inferior frontal gyrus (triangular part), right angular gyrus, right median cingulate and paracingulate gyri, and right middle temporal gyrus. Conversely, increased DC was observed in the right fusiform gyrus, right hippocampus and left inferior temporal gyrus. FC analysis revealed that altered connectivity predominantly occurred between the right middle temporal gyrus, right angular gyrus and left inferior frontal gyrus (triangular part). Notably, the DCvaluein the right median cingulate was positively correlated withthe Trail Making Test Part A scores in DM1 patients (r = 0.616, p = 0.005, adjusted p <0.05). No significant correlations were discovered between FC values and neurocognitive performances. Conclusion: The study demonstrated that abnormalities in degree centrality and functional connectivity may become potential neuroimaging biomarkers for cognitive decline in DM1 patients.
Myofascial release (MFR) therapy is widely used in clinical practice to treat various musculoskeletal and pain-related conditions. However, there is a lack of comprehensive reviews that systematically evaluate its effectiveness across different medical conditions, leading to inconsistent applications and understanding of its therapeutic potential. This review aims to synthesize the current applications of myofascial release therapy in the treatment of various diseases, highlighting its efficacy and identifying areas where further research is needed. The review covers the application of myofascial release therapy in conditions such as chronic pain, fibromyalgia, post-surgical recovery, and neurological disorders. It evaluates the outcomes of existing studies, identifies gaps in the literature, and discusses the mechanisms through which myofascial release exerts its effects. Additionally, the review provides insights into the limitations of current research and suggests directions for future studies to enhance the clinical application of myofascial release therapy.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2025 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.