Alterations in epidermal function in type 2 diabetes: Implications for the management of this disease

Man, Mao‐Qiang; Wakefield, Joan S.; Mauro, Theodora M.; Elias, Peter M.

doi:10.1111/1753-0407.13303

Cited by 11 publications

(9 citation statements)

References 99 publications

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“… 78 Elevated transepidermal water loss rates and reduced stratum corneum hydration levels have been observed in individuals with type 2 diabetes. 79 Individuals with obesity also exhibit higher transepidermal water loss rates than normal controls (14.27 ± 4.4 vs 11.3 ± 2.7, p < 0.05). 80 Interestingly, the severity of obesity is positively correlated with epidermal permeability.…”

Section: Association Of the Skin With Aging-associated Conditionsmentioning

confidence: 89%

Improvement in Cutaneous Conditions Can Benefit Some Health Conditions in the Elderly

Yang,

Man

2023

CIA

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As we are aging, a number of cutaneous and extracutaneous disorders will be developed. Although the pathogenesis of these aging-associated disorders is not clear yet, abnormalities in the skin are linked to some aging-associated disorders at least to some extent. Inflammatory dermatoses such as psoriasis and atopic dermatitis predispose to the development of cardiovascular diseases, obesity and type 2 diabetes. In addition, both chronologically aged skin and individuals with some aging-associated systemic conditions display altered epidermal function, such as reduced stratum corneum hydration levels, which can provoke cutaneous inflammation. Because aged skin exhibits higher expression levels of inflammatory cytokines, which play a pathogenic role in a variety of aging-associated health condition, the association of the skin with some aging-associated disorders is likely mediated by inflammation. This postulation is supported by the evidence that improvement in either epidermal function or inflammatory dermatoses can mitigate some aging-associated disorders such as mild cognitive impairment and insulin sensitivity. This perspective discusses the association of the skin with aging-associated disorders and highlights the potential of improvement in cutaneous conditions in the management of some health conditions in the elderly.

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Section: Association Of the Skin With Aging-associated Conditionsmentioning

confidence: 89%

Improvement in Cutaneous Conditions Can Benefit Some Health Conditions in the Elderly

Yang,

Man

2023

CIA

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“…Prior data show that diabetes compromises epithelial barriers in the brain, skin, and intestine, facilitating permeability to solutes, organic compounds, and pathogens. 48 – 52 Additionally, UPEC can disrupt urothelial barriers and exploit this damage to facilitate invasion. 53 Although the diabetes-associated mechanisms impairing barrier function are not defined, evidence points to a multitude of factors, including excessive inflammation, deregulated immune responses, lipotoxicity, dysbiosis, and hyperglycemia.…”

Section: Discussionmentioning

confidence: 99%

“… 53 Although the diabetes-associated mechanisms impairing barrier function are not defined, evidence points to a multitude of factors, including excessive inflammation, deregulated immune responses, lipotoxicity, dysbiosis, and hyperglycemia. 52 , 54 In the bladder, preclinical evidence suggests that hyperglycemia compromises barrier integrity, and exfoliated human urinary cells show suppressed expression of the tight junction protein occludin. 13 – 15 , 55 , 56 Here, we show a direct relationship between IR impairment and urothelial permeability to solutes and pathogens.…”

Section: Discussionmentioning

confidence: 99%

Insulin receptor signaling engages bladder urothelial defenses that limit urinary tract infection

Schwartz,

Salamon,

Simoni

et al. 2024

Cell Reports

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“…Hal ini membuat peneliti tertarik untuk mengetahui apakah terdapat korelasi antara hidrasi kulit dengan gula darah sewaktu. (Akdeniz et al, 2018;Camilion et al, 2022;Man et al, 2022).…”

Section: Pendahuluanunclassified

Korelasi Kadar Gula Darah Sewaktu dengan Kadar Air dan Sebum Kulit di Rukun Warga (RW) 008 Kelurahan Cipondoh

Yudhitiara,

Tan,

Yogie

et al. 2023

Mal Health Stu J.

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Skin hydration is influenced by various factors. Blood glucose levels are also known to affect the protective function of the skin. This cross-sectional study aims to investigate the profile of skin hydration status and its correlation with blood glucose levels among subjects at RW 08 Cipondoh. Skin hydration status measurements were done using an Over The Counter (OTC) skin analyzer. Blood glucose levels were measured using Point of Care Testing (POCT) Out of 101 respondents, the average age was 51.38 years with 75.2% of the respondents were female. The mean blood glucose was 122.71 mg/dL. The mean oil and water hydration were 22.99% and 42.96%, respectively. The data showed a negative correlation between blood glucose and water hydration, with a correlation coefficient power of 0.319 significantly, and between blood glucose and oil hydration, with 0.236 significantly. This study concludes that higher blood glucose levels was associated with worse skin hydration status. Keywords : Blood glucose, Hydration Status ABSTRAK Kelembaban kulit dipengaruhi oleh banyak faktor. Kadar gula darah merupakan salah satu faktor yang dapat mempengaruhi fungsi kelembaban kulit. Penelitian potong lintang ini bertujuan untuk mengetahui gambaran status hidrasi kulit dan korelasinya dengan kadar gula darah pada komunitas yang tinggal di RW 08 Cipondoh. Pengukuran status hidrasi kulit menggunakan alat Over The Counter (OTC) skin analyzer. Kadar gula darah diukur menggunakan Point of Care Testing (POCT). Dari 101 responden, rata-rata usia subjek penelitian adalah 51,38 tahun dengan 75,2% responden adalah perempuan. Rerata gula darah sewaktu (GDS) sebesar 122,71 mg/dL. Rerata hidrasi sebum dan air, masing-masing sebesar 22,99% dan 42,96%. Hasil uji statistik menunjukan hasil korelasi negatif antara GDS dengan hidrasi air sebesar 0,319 secara signifikan dan hidrasi sebum sebesar 0,236 secara signifikan. Penelitian ini menyatakan bahwa semakin tinggi kadar gula darah, maka semakin menurun status hidrasi kulit seseorang. Kata Kunci: Kadar Gula Darah, Kadar Hidrasi

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Alterations in epidermal function in type 2 diabetes: Implications for the management of this disease

Cited by 11 publications

References 99 publications

Improvement in Cutaneous Conditions Can Benefit Some Health Conditions in the Elderly

Improvement in Cutaneous Conditions Can Benefit Some Health Conditions in the Elderly

Insulin receptor signaling engages bladder urothelial defenses that limit urinary tract infection

Korelasi Kadar Gula Darah Sewaktu dengan Kadar Air dan Sebum Kulit di Rukun Warga (RW) 008 Kelurahan Cipondoh

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