Alterations in hepatic lipase and lipoprotein subfractions with transdermal testosterone replacement therapy

Abstract

Testosterone replacement, given via a permeation-enhanced transdermal system, is associated with changes in hepatic lipase activity and in LDL and HDL subfractions. Whether these changes adversely influence the cardiovascular risk in the longterm remains to be determined.

Testosterone administration to men increases hepatic lipase activity and decreases HDL and LDL size in 3 wk

“…LDL buoyancy decreased with T administration in this study, consistent with the data from Tan et al (32), wherein T was administered via a scrotal patch to hypogonadal men for 3 mo. In the Tan et al study, LDL was divided into three subfractions by DGUC, with subfraction III being the most dense and subfraction I the least dense.…”

“…When HDL-C declines with T administration in both eugonadal and hypogonadal men, it is unclear whether this decrease is in the subclasses HDL 2 (22) or HDL 3 (32)(33)(34) or both. That HDL-C decreases with T administration might be important for long-term use of T in men, because low HDL-C, including low HDL 2 and low HDL 3 , is associated with an increased risk for cardiovascular disease (3,14,26).…”

“…In addition, HL by the same mechanism converts large, buoyant LDL to small, dense LDL (41), the latter also being a risk factor for cardiovascular disease (2,24,31). One study demonstrated an increase in one population of small, dense LDL particles with T administration to hypogonadal men (32), but a cross-sectional study demonstrated an inverse association between serum T levels and small, dense LDL (29), although the T levels in that study have been called into question (35).…”

Obesity Related Lipid Profile and Altered Insulin Incretion in Adolescent with Policystic Ovary Syndrome

“…Considerable controversy exists as to the effect of androgens on lipoprotein lipase (LPL) activity. In obese women LPL activity correlated positively with plasma free testosterone (32), whereas in women with PCOS a correlation with LPL activity was demonstrated.…”

Prevalência dos fatores de risco cardiovascular em homens transexuais em tratamento com ésteres de testosterona e sua associação com as variantes polimórficas do gene do receptor androgênico

“…As ações da testosterona sobre a redução do HDLc são principalmente determinadas pelo aumento da lipase hepática, enzima que hidrolisa fosfolípides da superfície desta lipoproteína e que contribui para redução do seu tempo de residência na circulação (136). O tabagismo é relatado na literatura como um vício frequente entre indivíduos transexuais e é reconhecidamente um fator de impacto importante no risco CV.…”