2003
DOI: 10.1016/s0271-5317(03)00163-5
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Alterations in intestinal morphology of streptozotocin-induced diabetic rats fed Jamaican bitter yam (Dioscorea polygonoides) steroidal sapogenin extract

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Cited by 26 publications
(31 citation statements)
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“…The cells of the small intestine have the ability to adapt their structure and function with changes in the intraluminal content of the nutrients. Decreased permeability of the intestinal brush border to minerals such as sodium in the presence of saponins lowers the driving force of glucose transport [4,5]. Also, inhibition of gastric emptying by saponins prolongs postprandial absorption of food and thus improves blood glucose control, which is beneficial in the management of diabetes.…”
Section: Bitter Yam Sapogenin and Intestinal Morphologymentioning
confidence: 99%
“…The cells of the small intestine have the ability to adapt their structure and function with changes in the intraluminal content of the nutrients. Decreased permeability of the intestinal brush border to minerals such as sodium in the presence of saponins lowers the driving force of glucose transport [4,5]. Also, inhibition of gastric emptying by saponins prolongs postprandial absorption of food and thus improves blood glucose control, which is beneficial in the management of diabetes.…”
Section: Bitter Yam Sapogenin and Intestinal Morphologymentioning
confidence: 99%
“…44 Various aldehydes derived from lipid hydroperoxides can be measured to quantify LPO as they reflect the extent of damage associated with oxidative stress at the tissue and cellular levels. These aldehydes have longer half-lives than reactive free radicals and can diffuse from their site of origin, circulate freely in the blood vessels or incorporate with lipoproteins, thereby reaching and attacking target sites.…”
mentioning
confidence: 99%
“…These aldehydes have longer half-lives than reactive free radicals and can diffuse from their site of origin, circulate freely in the blood vessels or incorporate with lipoproteins, thereby reaching and attacking target sites. 44 Notably, LPO causes a prominent increase in malondialdehyde and thiobarbituric acid-reactive substances in the livers of people with DM. 3 The formation of these products alters the transbilayer fluidity gradient of plasma membranes and damages the membrane components.…”
mentioning
confidence: 99%
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“…Owing to its bitter taste as the name implies, the wild forms are rarely eaten except during famine [18]. Furthermore, aside certain medicinal uses and potential application in baking, bitter yam has no established industrial application at present [15,[18][19][20].…”
Section: Introductionmentioning
confidence: 99%