Alterations in lipid and hormonal titers in patients with acne and their relationship with severity: A case‐control study

Abstract

Background and Aims Acne is a frequently diagnosed skin condition that causes pilosebaceous apparatus clogs and/or inflammatory responses in the majority of teenagers. It is a multifactorial disease that can develop due to various factors. We aimed to evaluate lipid profiles and hormonal levels in patients with acne and correlate them to acne severity. We also aim to explore the alteration of lipid profiles and hormonal levels and their effect on the occurrence of acne. Methods A case‐control study was performed on 100 individuals with acne vulgaris and 100 healthy controls. The biochemical analysis included; lipid profiles such as triglycerides (TG), total cholesterol (TC), low‐density lipoprotein cholesterol (LDL‐C), and high‐density lipoprotein cholesterol (HDL‐C), and hormonal levels such as estradiol (E), total testosterone (TT), and free testosterone (FT) were measured for both patients and controls. Results Comparison between patients with acne and controls disclosed that; TC, TG, LDL‐C, and HDL‐C levels were significantly higher in patients, especially when compared to controls (p ≤ 0.05); also, the same results were found in hormonal levels results (p ≤ 0.05). Conclusion These altered lipid profiles and androgen levels should be considered in the pathophysiology of acne and taken into consideration when treating patients with acne.

C‐reactive protein as a novel biomarker for vitamin D deficiency in alopecia areata

“…Autoimmune processes in AA may be impacted by vitamin D regulation of immune responses through VDR. 5 Several studies in our population have tried to find the relation between different biochemical parameters and different skin diseases such as acne, [6][7][8][9][10] and psoriasis vulgaris [11][12][13][14][15] but according to our knowledge, there is no study able to find the relation between CRP and vitamin D in AA patients.…”

MiR‐200c‐3p as a novel genetic marker and therapeutic tool for alopecia areata

“…14 In our population, several studies have been conducted to understand the relationship between genetic factors and dermatological conditions. [15][16][17][18][19][20][21][22][23][24] However, according to our knowledge, no study tries to determine the mechanisms by which miRNAs contribute to AA.…”

A meta-analysis of the incidence of acne vulgaris in patients treated with GLP-1 agonists

“…[9][10][11][12][13] Adipose tissue itself also contains both estrogen and androgen receptors. 9,12,13 Studies have shown that patients with acne who consume food that has a lower glycemic load tend to have less lesions than those who consume diets with a higher glycemic load. 10 Weight loss has been shown to improve factors that contribute to both the inflammatory and endogenous factors that contribute to acne.…”

“…Acne vulgaris is caused by excessive sebum production, inflammation, follicular hyperkeratinization, or Propionibacterium acnes bacterial colonization of the pilosebaceous unit in the skin. 9…”

“…Acne vulgaris is caused by excessive sebum production, inflammation, follicular hyperkeratinization, or Propionibacterium acnes bacterial colonization of the pilosebaceous unit in the skin. 9 Multiple factors have been shown to contribute to acne development, including genetic, hormonal, inflammatory, and environmental influences. 9,10 Hormones modulate the pilosebaceous unit, especially androgens.…”