Alterations in Maternal Corticosteroid Levels Influence Fetal Urine and Lung Liquid Production

Jensen, Ellen C.; Wood, Charles E.; Keller‐Wood, Maureen

doi:10.1016/s1071-55760300153-9

Cited by 3 publications

(1 citation statement)

References 19 publications

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“…Fetuses maintain blood volume by reducing the lung fluid and urine production despite attenuation in maternal blood volume (48). In contrast, renal regulation is important in body fluid balance.…”

Section: Fetal Renal Regulationmentioning

confidence: 99%

Fetal development of regulatory mechanisms for body fluid homeostasis

Guan

Mao

Feng

et al. 2008

Braz J Med Biol Res

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The balance of body fluids is critical to health and the development of diseases. Although quite a few review papers have shown that several mechanisms, including hormonal and behavioral regulation, play an important role in body fluid homeostasis in adults, there is limited information on the development of regulatory mechanisms for fetal body fluid balance. Hormonal, renal, and behavioral control of body fluids function to some extent in utero. Hormonal mechanisms including the renin-angiotensin system, aldosterone, and vasopressin are involved in modifying fetal renal excretion, reabsorption of sodium and water, and regulation of vascular volume. In utero behavioral changes, such as fetal swallowing, have been suggested to be early functional development in response to dipsogens. Since diseases, such as hypertension, can be traced to fetal origin, it is important to understand the development of fetal regulatory mechanisms for body fluid homeostasis in this early stage of life. This review focuses on fetal hormonal, behavioral, and renal development related to regulation of body fluids in utero.

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Section: Fetal Renal Regulationmentioning

confidence: 99%

Fetal development of regulatory mechanisms for body fluid homeostasis

Guan

Mao

Feng

et al. 2008

Braz J Med Biol Res

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Mineralocorticoid Receptor Expression in Late-Gestation Ovine Fetal Lung

Keller‐Wood

Wood²,

Hua³

et al. 2005

Journal of the Society for Gynecologic Investigation

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Changes in adrenal corticosteroid secretion result in changes in lung liquid production in the late-gestation fetus. To test for the presence of mineralocorticoid receptor (MR) in fetal pulmonary epithelium, lungs from fetal sheep of 120 to 130 days' gestation (term about 148 days) were collected and frozen for identification of mRNA for MR in homogenates by reverse transcriptase polymerase chain reaction (RT-PCR) or for determination of 3H-cortisol binding at MR. Other samples of fetal lungs were fixed for localization of MR and Na+, K+ adenosine triphosphatase (ATPase) alpha by immunohistochemistry. MR mRNA was identified in lung tissue from fetuses and newborn lambs, but not from pregnant ewes; MR-regulated genes, including SGK1 and ENaCalpha were also expressed in fetal and newborn lungs. Immunoreactive MR was found in pulmonary epithelial cells and to be colocalized with Na+, K+ ATPase alpha in many sites. These results indicate that the molecular apparatus for mineralocorticoid-stimulated lung liquid reabsorption is present in epithelium by 120 days' gestation.

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The critical importance of the fetal hypothalamus-pituitary-adrenal axis

Wood

Keller‐Wood

2016

F1000Res

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The fetal hypothalamus-pituitary-adrenal (HPA) axis is at the center of mechanisms controlling fetal readiness for birth, survival after birth and, in several species, determination of the timing of birth. Stereotypical increases in fetal HPA axis activity at the end of gestation are critical for preparing the fetus for successful transition to postnatal life. The fundamental importance in fetal development of the endogenous activation of this endocrine axis at the end of gestation has led to the use of glucocorticoids for reducing neonatal morbidity in premature infants. However, the choice of dose and repetition of treatments has been controversial, raising the possibility that excess glucocorticoid might program an increased incidence of adult disease (e.g., coronary artery disease and diabetes). We make the argument that because of the critical importance of the fetal HPA axis and its interaction with the maternal HPA axis, dysregulation of cortisol plasma concentrations or inappropriate manipulation pharmacologically can have negative consequences at the beginning of extrauterine life and for decades thereafter.

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Alterations in Maternal Corticosteroid Levels Influence Fetal Urine and Lung Liquid Production

Abstract: Alterations in maternal adrenal corticosteroid levels resulted in fetal adaptation to maintain fetal blood volume despite relative maternal hypovolemia. These adaptations occurred at the expense of fetal urine and lung liquid production.

Cited by 3 publications

References 19 publications

Fetal development of regulatory mechanisms for body fluid homeostasis

Fetal development of regulatory mechanisms for body fluid homeostasis

Mineralocorticoid Receptor Expression in Late-Gestation Ovine Fetal Lung

The critical importance of the fetal hypothalamus-pituitary-adrenal axis

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