Alterations in microbiota-metabolism-circRNA crosstalk in autism spectrum disorder-like behaviours caused by maternal exposure to glyphosate-based herbicides in mice

He, Xiu; Yang, Yongyong; Zhou, Shun; Wei, Qinghao; Zhou, Hao; Tao, Junyan; Yang, Guanghong; You, Mingdan

doi:10.1016/j.ecoenv.2024.117060

Ecotoxicology and Environmental Safety

2024

DOI: 10.1016/j.ecoenv.2024.117060

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Alterations in microbiota-metabolism-circRNA crosstalk in autism spectrum disorder-like behaviours caused by maternal exposure to glyphosate-based herbicides in mice

Xiu He,

Yongyong Yang,

Shun Zhou

et al.

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Mechanisms of Neurotoxicity of Organophosphate Pesticides and Their Relation to Neurological Disorders

Chen,

Yang,

Nian

et al. 2024

NDT

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Organophosphates (OPs) refers to a diverse group of phosphorus-containing organic compounds; they are widely used all over the world and have had an important beneficial impact on industrial and agricultural production and control of vector transmission. Exposure to OPs of different toxicities (high, moderate, slight, and low toxicity) can all have negative consequences on the nervous system, such as nausea, vomiting, muscle tremors, and convulsions. In severe cases, it can lead to respiratory failure or even death. Notably, OPs induce neuropathy in the nervous system through specific interactions with nicotinic or muscarinic receptors, phosphorylating acetylcholinesterase, or neuropathic target esterases. This review summarizes the possible toxicological mechanisms and their interplay underlying OP pesticide poisoning, including cholinesterase inhibition and non-cholinesterase mechanisms. It outlines the possible links between OP pesticide poisoning and neurological disorders, such as dementia, neurodevelopmental diseases, and Parkinson’s disease. Additionally, it explores OP interactions’ potential therapeutic implications that may help mitigate the deleterious impact of OPs on the nervous system.

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Mechanisms of Neurotoxicity of Organophosphate Pesticides and Their Relation to Neurological Disorders

Chen,

Yang,

Nian

et al. 2024

NDT

View full text Add to dashboard Cite

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Alterations in microbiota-metabolism-circRNA crosstalk in autism spectrum disorder-like behaviours caused by maternal exposure to glyphosate-based herbicides in mice

Cited by 1 publication

References 87 publications

Mechanisms of Neurotoxicity of Organophosphate Pesticides and Their Relation to Neurological Disorders

Mechanisms of Neurotoxicity of Organophosphate Pesticides and Their Relation to Neurological Disorders

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