Alterations in Plasma Electrolytes and Serum Liver Enzymes Induced by Atenolol in Common Rabbits Oryctolagus cuniculus

Hasan, Ruqaiya; Javaid, Aisha; Fatima, Hira; Safdar, Wajeeha

doi:10.3923/pjbs.2006.2342.2345

Cited by 4 publications

(3 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Table 2 shows a comparison of serum ALT levels in hypertensive and cardiac patients treated with different therapeutic antihypertensive drugs, falling in normal range, except only two patients receiving treatment of Beta-blockers and diuretic, showing slightly high serum ALT levels. According to Chernecky and Berger [11], there is indicative effect of the Beta-blockers on liver, and probably resulting in liver damage [12]. However another study by Ford et al [13], in middle-to-older aged subjects without evidence of clinically significant liver damage showed an inverse relationship between ALT levels and risk of fatal and non fatal cardiovascular diseases.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study of the Antihypertensive Agents on Serum Liver Enzymes ALT, AST and ALP of Hypertensive and cardiac Patients

Mk¹

2021

J. Basic Appl. Sci.

View full text Add to dashboard Cite

Present study is done to compare serum Liver enzymes including Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST) and Alkaline Phosphatase (ALP) in hypertensive and cardiac patients. 24 patients were divided into 4 groups according to their treatment with 4 different types of antihypertensive drugs. Group I treated with Beta-blockers (1+1). Group II treated with ACE-Inhibitor once a day. Group III treated with Nitrates once a day. Group IV is taking Diuretics once a day. Data showed non-significant difference in serum ALT concentration in all groups. A significant rise (p< 0.05) in serum AST and ALP levels among hypertensive and cardiac patients is observed, ranging from 24.63-47.33U/L and 110-2484 U/L respectively when compared with normal controls. Thus, not only the risk of cardiac diseases in future might be predicted by altered levels of enzymes ALT, AST and ALP in serum but their concentrations should be monitored during the treatment of cardiac diseases to minimize the risk of cardiac arrest.

show abstract

Section: Discussionmentioning

confidence: 99%

A Comparative Study of the Antihypertensive Agents on Serum Liver Enzymes ALT, AST and ALP of Hypertensive and cardiac Patients

Mk¹

2021

J. Basic Appl. Sci.

View full text Add to dashboard Cite

show abstract

“…Further, previous studies suggested that long term induction of atenolol lead to cardiotoxicity in terms increase in oxidative stress in rats [16]. Furthermore, existing information suggested that long term treatment with atenolol used as an antihypertensive agent causes increase in serum liver enzymes in rabbit [17]. To reduce the danger of sickness and bad consequences, as well as to achieve excellent health, a large section of the world's population favored natural therapies over or in combination with allopathic drugs [18].…”

Section: Introductionmentioning

confidence: 99%

"Amelioration of Atenolol Induced Hyperlipidemia by Glycine Max"

Mir

2023

BJSTR

View full text Add to dashboard Cite

Beta-blocker atenolol is a well-known anti-hypertensive drug that has tendency to cause changes in the patient's normal lipid profile.Aim: This study aims to prevent this harmful impact of Atenolol utilising Glycine max seeds, a cost-effective, widely accessible nutraceutical that is more physiologically compatible than other choices. Materials and Method:Wistar rats were given a diet with 8% sodium chloride to induce hypertension and subsequently sacrificed. Glycine max powder was used to reduce atenolol's side effects during the trial. Thirty rats were divided into five groups and tested over eight weeks. Rats' blood pressure (BP) was measured with a tail-cuff NIBP monitor. Biochemical markers like TG, TC, HDL, LDL, VLDL, alanine transferase, aspartate transferase, lipid peroxide (LPO), catalase, and super oxide dismutase (SOD) were evaluated.Results: Glycine max seeds may minimize the effects of Atenolol on the lipid profile by reducing blood cholesterol, increasing antioxidant levels, and maintaining liver function. When glycine max and Atenolol were administered together, there was a substantial decrease in TC, TG, LDL, VLDL, and HDL levels, SOD, catalase and increase in MDA, AST and ALT as compared to the normal control group (p≤0.05).Conclusion: SBP (systolic blood pressure) and DBP (diastolic blood pressure) are lowered considerably compared to a control diet, however the amount depends on pre-treatment BP measurements and baseline comparison diet. Combining Atenolol with glycine max not only improves blood pressure but also modifies lipid profile. In rats with atenolol-induced hyperlipidemia, glycine max reduces oxidative stress and liver damage.

show abstract

“…Therefor, the decreased intracellular calcium results in a vasorelaxant effect and lowering blood pressure [15]. [16] found out that the effect of atenolol on plasma calcium was significantly reduced to the half of the normal values in rabbits after 27 days, these findings suggest that atenolol may control blood pressure by the suppression of renninangiotensin-aldosteron pathway which accompanied by a reduction of sodium and calcium concentration. So, this study refers to the diuretic action of atenolol concomitantly, the positive impact of atenolol is due to decreases in sodium and calcium by decreases in sympathetic overactivity and excreation of sodium and calcium by improvement in kidney function,and this will inhibite the renal sympathatic stimulation to renine release by β1adrenergic receptors and sodium reabsorption [17].…”

mentioning

confidence: 97%

The protective impact of vitamin E against atenolol effect on Ca+2, Testosteron and FSH in male rats

Abbas,

Khalil

2016

Kufa Jou. Vete. Med. Sci.

View full text Add to dashboard Cite

Background and objective: Atenolol is β1-selective antagonist nonetheless this selectivity is not absolute and at higher dosages atenolol represses β-2 Adrenoceptors mainly located in bronchial and vascular musculature, alsoβ-blocker atenolol effects on testosterone and FSH production. Therefore ,this study was designed to investigate the possible protective effect of vitamin E on reproductive efficiency in male rats exposed to atenolol. Materials and methods:Thirty-two healthy adult males Wistar rats at random divided into four equal groups and treatment for 56 days as follows:-First group (control):Animals in this group received tap water and served as control.Second group (group T1):Animal in this group will be receive atenolol orally at dose (100mg/kg/day).Third group (group T2):Animal in this group will be receive Vit.E (800IU /B.W.) orally and Fourth group (group T3):Animal in this group will be receive Vit.E (800IU/B.W.) and atenolol at dose (100mg/kg/B.W.) orally. Results: serum level of serum testosterone in control group was 1.51±0.21 ng/ml, and it significantly decreased in atenolol treated group (0.74±0.008 ng/ml),.Serum level of FSH in the control group was (4.87±0.03 mIU /ml) while it significantly reduced in atenolol treated group (2.69±0.15mIU/ml), also the results showed that atenolol was a significantly decrease the Ca+2 concentration to (1.20 ± 0.15 mg/dl) in contrast to control group.Conclusion: Vitamin E improve significantly the levels of serum FSH and testosterone in in atenolol treated rats.

show abstract

Alterations in Plasma Electrolytes and Serum Liver Enzymes Induced by Atenolol in Common Rabbits Oryctolagus cuniculus

Cited by 4 publications

References 7 publications

A Comparative Study of the Antihypertensive Agents on Serum Liver Enzymes ALT, AST and ALP of Hypertensive and cardiac Patients

A Comparative Study of the Antihypertensive Agents on Serum Liver Enzymes ALT, AST and ALP of Hypertensive and cardiac Patients

"Amelioration of Atenolol Induced Hyperlipidemia by Glycine Max"

The protective impact of vitamin E against atenolol effect on Ca+2, Testosteron and FSH in male rats

Contact Info

Product

Resources

About