Alterations in Plasma Glucose and Cardiac Antioxidant Enzymes Activity in Streptozotocin-Induced Diabetic Rats: Effects of Trigonella foenum-graecum Extract and Swimming Training

Haghani, Karimeh; Bakhtiyari, Salar; Mohammadpour, Jafar Doost

doi:10.1016/j.jcjd.2015.08.012

Cited by 17 publications

(6 citation statements)

References 49 publications

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“…A broad spectrum of scientific data and systematic reviews demonstrate that fenugreek seed extract attenuates mental alertness and mood as well as serum lipid function and lowers fasting and post-prandial blood glucose levels, in addition to glycosylated hemoglobin [1][2][3][4][5][6]. In another set of investigations, fenugreek seed extract improved serum testosterone level, exercise performance, and endurance capacity and lowered hyperglycemia in a variety of rodent models and humans [7][8][9][10]. Another group of investigators exhibited an elevated muscle glycogen synthesis after exhaustive exercise in athletes following supplementation of fenugreek seed extract [11].…”

Section: Introductionmentioning

confidence: 99%

Furosap, a novel Fenugreek seed extract improves lean body mass and serum testosterone in a randomized, placebo-controlled, double-blind clinical investigation

Guo¹,

Wang²,

Nair³

et al. 2018

FFHD

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Background: The Indian spice fenugreek (Trigonella foenum-graecum) has been credited with numerous health benefits in cardiovascular disorders, metabolic syndrome, inflammatory conditions, glucose-insulin regulation, and sports performance. Previous studies from our laboratories demonstrated that fenugreek seed extract improved glucose tolerance, insulin sensitivity, augmented serum testosterone level and improved cardiovascular functions. Our investigation examined the efficacy of Furosap, a novel fenugreek seed extract enriched in 20% protodioscin, on exercise performance. Methods: This randomized, double-blind, placebo-controlled, clinical study was conducted in forty healthy male athletes (n = 40) over a period of 12 consecutive weeks. Subjects were given either placebo or Furosap capsules (250 mg/day b.d.) and serum samples were used to assess serum total testosterone level and C-reactive proteins (CRP) at baseline and at the end of 12-weeks of treatment. Body fat mass, lean mass, fat mass, fat-free mass, grip strength, upper and lower body strength, maximal graded exercise stress using a digital hand dynamometer, dual-energy X-ray absorptiometry (DEXA), force plate, and treadmill with open-circuit spirometry were assessed at the baseline and at the end of 12-weeks of treatment.Results: Furosap supplementation significantly increased mean lean body mass and fat-free mass compared to subjects receiving placebo. Additionally, Furosap-treated subjects elevated serum testosterone levels. Furosap supplemented subjects also exhibited a tendency towards lowering blood pressure during exhaustion. No adverse reports were reported.Conclusions: Given improvement of lean body mass and serum total testosterone following intervention with Furosap, Furosap likely has benefits for exercise endurance and sports medicine. Keywords: Fenugreek seed extract; safety; body mass; fat-free mass; blood pressure; muscle strength.

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Section: Introductionmentioning

confidence: 99%

Furosap, a novel Fenugreek seed extract improves lean body mass and serum testosterone in a randomized, placebo-controlled, double-blind clinical investigation

Guo¹,

Wang²,

Nair³

et al. 2018

FFHD

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“…The observed depletion of GSH content in the tissues of rats and its normalization with Astaxanthin suggested its potent antioxidant properties and we hypothesized that ASTA as a functional food supplement decreases oxidative stress invivo due to both of improved antioxidant activities and decreased peroxidation processes. Another mechanism that was suggested is that ASTA via its antioxidant properties prevents the death of β pancreatic cells, allowing healing of partially destroyed cells as an oxidizing agent mellitus (Haghani et al, 2016) 27.…”

Section: Resultsmentioning

confidence: 99%

Astaxanthin as Potential Antioxidant Agent Protects from Accumulation of Heavy-metals in Brain

Al-Bulish¹

2017

Journal of Agricultural, Environmental and Veterinary Sciences

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Humans are increasingly exposed to heavy-metals from food, water, medicine, vaccines, and cosmetics. The toxicity of heavy-metals in humans is briefly summarized, links the possible causal relationships between a high heavy-metals body burden and a number of neurological disorders including Alzheimer’s, Parkinson and Autism disorders. This study aimed to assess the antioxidant properties of Astaxanthin (ASTA) to determine the effect of orally administered ASTA capability of restrict accumulation and toxicity of heavy-metals in brain of rats. It also, assess against Hydrogen peroxide induced oxidative stress and antioxidant potential properties of ASTA with comparing the affectivity of 5% and 10% of ASTA in increased glutathione-recycling enzymes (GPx oxidation). A significant change was observed as increased glutathione-recycling enzymes (GPx oxidation) of rats and showed a protective effect against accumulation of Aluminum(AL) in rat’s brain tissues. The results of this in-vivo study demonstrated that ASTA 10% is more can affective in restriction of accumulation and toxicity of Al in rate brain and its contented can protects against oxidative-stress.

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“…Reduced myocyte hypertrophy and decreased collagen deposition ( brosis), evidencing cardiac damage, was observed in Sprague-Dawley rats trained at 80% of their maximum capacity for four weeks, showing that the high-intensity exercise was able to reverse cardiac remodeling in the diabetic heart [52]. In previous work in which diabetes was induced using alloxan and training was performed at above 80% of maximum intensity, positive impacts on cardiac remodeling were found, as evidenced by a reduction in myocyte hypertrophy and decreased collagen deposition ( brosis) [52,54], normalization of the increased levels of collagen type III, and reduced apoptosis and myocardial brosis [20].…”

Section: Discussionmentioning

confidence: 97%

Swimming Exercise Modifies Oxidative Stress in Skeletal and Cardiac Muscles of Diabetic Rats

Pio

Orzari²,

Alves

et al. 2020

Preprint

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Abstract Background: Oxidative stress is a key factor in the worsening of diabetes, requiring an increase in the activity of the antioxidant system, culminating in a balance in the body. The aim of the present study was to evaluate the redox state in the skeletal and cardiac muscles in rats induced to diabetes model and submitted to swimming exercise training for 4 weeks. Methods: Wistar rats were separated into the following four groups: untrained control (C); trained control (T); untrained alloxan-induced diabetes (D); trained alloxan-induced diabetes (TD). The animals were submitted to swimming exercise training for 4 weeks. The redox state of skeletal and cardiac muscles was analyzed by TBARS, -SH groups and, H2O2 production as well as by the SOD and Catalase activity. Besides, a histomorphometry analysis was performed in the cardiac muscle in which the total number of cardiomyocytes and the total area of collagen fibers were measured.Results: On the Soleus muscles, the TD group showed increased of H2O2 and Catalase compared to T group; and SOD compared to D group. About the red gastrocnemius, TD group presented higher SOD and lower Catalase relation to D group. Regarding to cardiac muscle, TD group presented lower TBARS than D group, while it was higher in -SH groups and Catalase compared to D group. Moreover, the swimming exercise led to a decrease in hyperglycemia, benefits in pathogenesis and physio-pathogenesis, evidenced by a reduced number of cardiomyocytes and area of collagen fibers. Conclusions: The swimming protocol exercise in diabetic rats was able to control the hyperglycemia, control of oxidative damage and minimize the fibrosis on cardiac muscle in diabetic rats.

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Alterations in Plasma Glucose and Cardiac Antioxidant Enzymes Activity in Streptozotocin-Induced Diabetic Rats: Effects of Trigonella foenum-graecum Extract and Swimming Training

Cited by 17 publications

References 49 publications

Furosap, a novel Fenugreek seed extract improves lean body mass and serum testosterone in a randomized, placebo-controlled, double-blind clinical investigation

Furosap, a novel Fenugreek seed extract improves lean body mass and serum testosterone in a randomized, placebo-controlled, double-blind clinical investigation

Astaxanthin as Potential Antioxidant Agent Protects from Accumulation of Heavy-metals in Brain

Swimming Exercise Modifies Oxidative Stress in Skeletal and Cardiac Muscles of Diabetic Rats

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