Alterations in resting-state functional connectivity in patients with Crohn’s disease in remission

Hou, Jiancheng; Mohanty, Rosaleena; Nair, Veena A.; Dodd, Keith; Beniwal-Patel, Poonam; Saha, Sumona; Prabhakaran, Vivek

doi:10.1038/s41598-019-43878-0

Cited by 24 publications

(27 citation statements)

References 52 publications

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“…This in turn might result in difficulties in interpersonal relationships and the development of psychological comorbidities, as well as problems in patient–physician interactions and decreased medication adherence ( Agostini et al, 2019 ; Colonnello and Agostini, 2020 ). This hypothesis is further supported by neuroimaging studies of patients with IBD, which found alterations in brain areas (e.g., the midcingulate cortex), that are involved in emotion processing ( Agostini et al, 2011 , 2013a , b , 2017 ; Vogt, 2013 ; Zikou et al, 2014 ; Kragel et al, 2018 ; Hou et al, 2019 ; Colonnello and Agostini, 2020 ; Fan et al, 2020 ; Skrobisz et al, 2020 ; Thomann et al, 2020 ; Turkiewicz et al, 2021 ; Yeung, 2021 ). This is in line with previous studies that reported that IBD patients are characterized by mentalizing deficits compared to healthy controls (HCs).…”

Section: Introductionmentioning

confidence: 72%

“…With regard to the psychological burden of anxiety and depression, the direction of (neuro-)inflammatory processes and disease activity in CD/UC seems to be bidirectional – with patients with anxiety symptoms developing more often disease flares, and patients with disease activity developing more anxiety ( Gracie et al, 2018 ). Additionally, recent neuroimaging studies have shown that patients with (active) IBD have an altered brain structure, which is associated with symptoms of depression and anxiety ( Agostini et al, 2011 , 2013a , b , 2017 ; Vogt, 2013 ; Zikou et al, 2014 ; Kragel et al, 2018 ; Hou et al, 2019 ; Colonnello and Agostini, 2020 ; Fan et al, 2020 ; Skrobisz et al, 2020 ; Thomann et al, 2020 ; Turkiewicz et al, 2021 ; Yeung, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

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Higher Levels of Psychological Burden and Alterations in Personality Functioning in Crohn’s Disease and Ulcerative Colitis

et al. 2021

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Aims: Is there evidence for increased psychological distress and alterations in personality functioning in patients with Crohn’s disease (CD) and ulcerative colitis (UC) compared to healthy controls (HCs)?Background: In patients with CD and UC, perceived stress is closely associated with changes in disease activity. The stress response is influenced by psychological burden and personality functioning, but only little is known about these factors in inflammatory bowel diseases (IBD).Study: A total of 62 patients with an endoscopic ensured CD/UC without remission (n = 31 per group) and 31 HC were included. Patients with an active CD/UC and HC were individually matched (n = 93, 31 per group) for age, sex, education, and disease activity. Depression and anxiety were assessed to evaluate the effect of psychological burden (Patient Health Questionnaire-9/PHQ-9, Generalized Anxiety Disorder-7/GAD-7). Personality functioning was measured by validated questionnaires for psychodynamic structural characteristics, mentalization, and attachment (Operationalized Psychodynamic Diagnosis-Structure Questionnaire/OPD-SQ, Mentalization Questionnaire/MZQ, and Experiences in Close Relationships scale/ECR-RD 12).Results: Levels of depression and anxiety were higher in CD/UC patients than in HC with large effect sizes. Comparing personality functioning in CD/UC with HC, psychodynamic structural characteristics differed between CD/UC and HC with medium effect sizes, with structural differences occurring primarily in the domain of self-perception and regulation. Only minor differences were found regarding mentalization and attachment. CD and UC differed only with small effect sizes.Conclusion: Our data show that compared to HC, patients with CD/UC are characterized by a higher level of psychological burden and structural alterations in the domain of self.

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Section: Introductionmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Higher Levels of Psychological Burden and Alterations in Personality Functioning in Crohn’s Disease and Ulcerative Colitis

et al. 2021

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“…Studies of brain structure in CD may be in agreement on one result, altered gray matter (GM) of the superior frontal gyrus, although laterality and direction of alteration are inconsistent (22)(23)(24). Studies of brain function in CD have reported numerous FC alterations with very little overlap (25)(26)(27)(28)(29)(30)(31)(32) aside from some agreement on changes in brain networks or regions involved in executive function and/or default mode (26,30,32). Our study aimed to identify brain structural and functional changes in CD as compared to HC.…”

Section: Introductionmentioning

confidence: 97%

Brain Resting-State Network Alterations Associated With Crohn's Disease

Kornelsen

Wilson

Labus³

et al. 2020

Front. Neurol.

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Inflammatory bowel disease (IBD) is a chronic disease that is associated with aspects of brain anatomy and activity. In this preliminary MRI study, we investigated differences in brain structure and in functional connectivity (FC) of brain regions in 35 participants with Crohn's disease (CD) and 21 healthy controls (HC). Voxel-based morphometry (VBM) analysis was performed to contrast CD and HC structural images. Region of interest (ROI) analyses were run to assess FC for resting-state network nodes. Independent component analysis (ICA) identified whole brain differences in FC associated with resting-state networks. Though no structural differences were found, ROI analyses showed increased FC between the frontoparietal (FP) network and salience network (SN), and decreased FC between nodes of the default mode network (DMN). ICA results revealed changes involving cerebellar (CER), visual (VIS), and SN components. Differences in FC associated with sex were observed for both ROI analysis and ICA. Taken together, these changes are consistent with an influence of CD on the brain and serve to direct future research hypotheses.

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“…Similar changes were found for ulcerative colitis (25). In inactive CD patients, the ReHo values in the superior frontal gyrus, putamen, anterior cingulate and supplementary motor areas were altered in other study (15,26,27). In addition, Bao et al found that the gray matter volumes in CD patients were changed in that brain region (8), which suggested that CD patients have abnormal brain activity and morphology.…”

Section: Discussionmentioning

confidence: 90%

Alterations of Regional Homogeneity in Crohn's Disease With Psychological Disorders: A Resting-State fMRI Study

Huang

Fan

et al. 2022

Front. Neurol.

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Abnormal psychological processing in the central nervous system has been found in Crohn's disease (CD) patients. Resting-state functional magnetic resonance images of 57 inactive and 58 active CD patients, and 92 healthy controls (HC) were obtained. The psychological assessment used a psychological questionnaire that was collected within 1 week before functional MRI examination. We investigated the neural basis of CD patients and the correlation among regional homogeneity (ReHo), clinical features and psychological assessment scores. We found that more severe psychological assessment disorder scores were observed in the active CD group than in the inactive CD group and HC group (P<0.001). Compared with HC, the active CD patients exhibited higher ReHo values in the frontal superior medial, frontal middle and lower values in the postcentral, supplementary motor area, and temporal middle. Meanwhile, inactive CD patients exhibited higher ReHo values in the frontal middle and lower ReHo values in the precentral, postcentral and putamen (all voxel P< 0.001, cluster P<0.01, corrected). The values of the frontal superior medial, postcentral and supplementary motor area were correlation with psychological assessment scores (r = 0.38, −0.41, −0.32, P = 0.001, 0.014, 0.003), and the clinical features of simple endoscopic score for Crohn's disease and erythrocyte sedimentation rate were negatively correlated with psychological assessment scores in active CD patients (r = −0.35, −0.34, P = 0.06, 0.08). These results provide evidence for abnormal resting-state brain activity in CD and suggest that the psychological of CD may play a critical role in brain function.

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Alterations in resting-state functional connectivity in patients with Crohn’s disease in remission

Cited by 24 publications

References 52 publications

Higher Levels of Psychological Burden and Alterations in Personality Functioning in Crohn’s Disease and Ulcerative Colitis

Higher Levels of Psychological Burden and Alterations in Personality Functioning in Crohn’s Disease and Ulcerative Colitis

Brain Resting-State Network Alterations Associated With Crohn's Disease

Alterations of Regional Homogeneity in Crohn's Disease With Psychological Disorders: A Resting-State fMRI Study

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